Hirsch E - Search Results

1

The catalytic PI3K isoforms p110gamma and p110delta contribute to B cell development and maintenance, transformation, and proliferation.

Beer-Hammer S, Zebedin E, von Holleben M, Alferink J, Reis B, Dresing P, Degrandi D, Scheu S, Hirsch E, Sexl V, Pfeffer K, Nürnberg B, Piekorz RP. Beer-Hammer S, et al. Among authors: hirsch e. J Leukoc Biol. 2010 Jun;87(6):1083-95. doi: 10.1189/jlb.0809585. Epub 2010 Mar 3. J Leukoc Biol. 2010. PMID: 20200404

2

Deficiency of PI3-Kinase catalytic isoforms p110γ and p110δ in mice enhances the IL-17/G-CSF axis and induces neutrophilia.

Bucher K, Schmitt F, Mothes B, Blumendeller C, Schäll D, Piekorz R, Hirsch E, Nürnberg B, Beer-Hammer S. Bucher K, et al. Among authors: hirsch e. Cell Commun Signal. 2017 Jul 19;15(1):28. doi: 10.1186/s12964-017-0185-y. Cell Commun Signal. 2017. PMID: 28724384 Free PMC article.

3

Phosphoinositide 3-kinases gamma and delta, linkers of coordinate C5a receptor-Fcgamma receptor activation and immune complex-induced inflammation.

Konrad S, Ali SR, Wiege K, Syed SN, Engling L, Piekorz RP, Hirsch E, Nürnberg B, Schmidt RE, Gessner JE. Konrad S, et al. Among authors: hirsch e. J Biol Chem. 2008 Nov 28;283(48):33296-303. doi: 10.1074/jbc.M804617200. Epub 2008 Sep 11. J Biol Chem. 2008. PMID: 18786920 Free PMC article.

4

p110γ/δ Double-Deficiency Induces Eosinophilia and IgE Production but Protects from OVA-Induced Airway Inflammation.

Mothes B, Bucher K, Ammon-Treiber S, Schwab M, Piekorz RP, Hirsch E, Nürnberg B, Beer-Hammer S. Mothes B, et al. Among authors: hirsch e. PLoS One. 2016 Jul 21;11(7):e0159310. doi: 10.1371/journal.pone.0159310. eCollection 2016. PLoS One. 2016. PMID: 27442134 Free PMC article.

5

Different inhibition of Gβγ-stimulated class IB phosphoinositide 3-kinase (PI3K) variants by a monoclonal antibody. Specific function of p101 as a Gβγ-dependent regulator of PI3Kγ enzymatic activity.

Shymanets A, Prajwal, Vadas O, Czupalla C, LoPiccolo J, Brenowitz M, Ghigo A, Hirsch E, Krause E, Wetzker R, Williams RL, Harteneck C, Nürnberg B. Shymanets A, et al. Among authors: hirsch e. Biochem J. 2015 Jul 1;469(1):59-69. doi: 10.1042/BJ20150099. Biochem J. 2015. PMID: 26173259 Free PMC article.

6

Correction: p110γ/δ Double-Deficiency Induces Eosinophilia and IgE Production but Protects from OVA-Induced Airway Inflammation.

Mothes B, Bucher K, Ammon-Treiber S, Schwab M, Piekorz RP, Hirsch E, Nürnberg B, Beer-Hammer S. Mothes B, et al. Among authors: hirsch e. PLoS One. 2016 Sep 19;11(9):e0163577. doi: 10.1371/journal.pone.0163577. eCollection 2016. PLoS One. 2016. PMID: 27644040 Free PMC article.

7

Frontline Science: Coincidental null mutation of Csf2rα in a colony of PI3Kγ-/- mice causes alveolar macrophage deficiency and fatal respiratory viral infection.

Schneider C, Nobs SP, Heer AK, Hirsch E, Penninger J, Siggs OM, Kopf M. Schneider C, et al. Among authors: hirsch e. J Leukoc Biol. 2017 Feb;101(2):367-376. doi: 10.1189/jlb.4HI0316-157R. Epub 2016 Jul 28. J Leukoc Biol. 2017. PMID: 27468760 Free PMC article.

8

Cutting edge: T cell development requires the combined activities of the p110gamma and p110delta catalytic isoforms of phosphatidylinositol 3-kinase.

Webb LM, Vigorito E, Wymann MP, Hirsch E, Turner M. Webb LM, et al. Among authors: hirsch e. J Immunol. 2005 Sep 1;175(5):2783-7. doi: 10.4049/jimmunol.175.5.2783. J Immunol. 2005. PMID: 16116162

9

The p110delta catalytic isoform of PI3K is a key player in NK-cell development and cytokine secretion.

Kim N, Saudemont A, Webb L, Camps M, Ruckle T, Hirsch E, Turner M, Colucci F. Kim N, et al. Among authors: hirsch e. Blood. 2007 Nov 1;110(9):3202-8. doi: 10.1182/blood-2007-02-075366. Epub 2007 Jul 20. Blood. 2007. PMID: 17644738 Free article.

10

Essential role of the p110beta subunit of phosphoinositide 3-OH kinase in male fertility.

Ciraolo E, Morello F, Hobbs RM, Wolf F, Marone R, Iezzi M, Lu X, Mengozzi G, Altruda F, Sorba G, Guan K, Pandolfi PP, Wymann MP, Hirsch E. Ciraolo E, et al. Among authors: hirsch e. Mol Biol Cell. 2010 Mar 1;21(5):704-11. doi: 10.1091/mbc.e09-08-0744. Epub 2010 Jan 6. Mol Biol Cell. 2010. PMID: 20053680 Free PMC article.

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