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Transcriptional pathway signatures predict MEK addiction and response to selumetinib (AZD6244).
Dry JR, Pavey S, Pratilas CA, Harbron C, Runswick S, Hodgson D, Chresta C, McCormack R, Byrne N, Cockerill M, Graham A, Beran G, Cassidy A, Haggerty C, Brown H, Ellison G, Dering J, Taylor BS, Stark M, Bonazzi V, Ravishankar S, Packer L, Xing F, Solit DB, Finn RS, Rosen N, Hayward NK, French T, Smith PD. Dry JR, et al. Among authors: pratilas ca. Cancer Res. 2010 Mar 15;70(6):2264-73. doi: 10.1158/0008-5472.CAN-09-1577. Epub 2010 Mar 9. Cancer Res. 2010. PMID: 20215513 Free PMC article.
Druggable genomic landscapes of high-grade gliomas.
Ghanem P, Fatteh M, Kamson DO, Balan A, Chang M, Tao J, Blakeley J; Johns Hopkins Molecular Tumor Board Investigators; Canzoniero J, Grossman SA, Marrone K, Schreck KC, Anagnostou V. Ghanem P, et al. Front Med (Lausanne). 2023 Dec 8;10:1254955. doi: 10.3389/fmed.2023.1254955. eCollection 2023. Front Med (Lausanne). 2023. PMID: 38143440 Free PMC article.
CDK4/6 inhibition enhances SHP2 inhibitor efficacy and is dependent upon restoration of RB function in malignant peripheral nerve sheath tumors.
Wang J, Calizo A, Zhang L, Pino JC, Lyu Y, Pollard K, Zhang X, Larsson AT, Conniff E, Llosa N, Wood DK, Largaespada DA, Moody SE, Gosline SJ, Hirbe AC, Pratilas CA. Wang J, et al. Among authors: pratilas ca. bioRxiv [Preprint]. 2023 Feb 3:2023.02.02.526674. doi: 10.1101/2023.02.02.526674. bioRxiv. 2023. Update in: Sci Adv. 2023 Nov 24;9(47):eadg8876. doi: 10.1126/sciadv.adg8876 PMID: 36778419 Free PMC article. Updated. Preprint.
Single-cell multiomics identifies clinically relevant mesenchymal stem-like cells and key regulators for MPNST malignancy.
Wu LMN, Zhang F, Rao R, Adam M, Pollard K, Szabo S, Liu X, Belcher KA, Luo Z, Ogurek S, Reilly C, Zhou X, Zhang L, Rubin J, Chang LS, Xin M, Yu J, Suva M, Pratilas CA, Potter S, Lu QR. Wu LMN, et al. Among authors: pratilas ca. Sci Adv. 2022 Nov 4;8(44):eabo5442. doi: 10.1126/sciadv.abo5442. Epub 2022 Nov 2. Sci Adv. 2022. PMID: 36322658 Free PMC article.
Impact of Consolidative Radiation on Overall and Progression-Free Survival in Pediatric, Adolescent, and Young Adult Metastatic Bone and Soft Tissue Sarcoma.
Chang L, D'Amiano A, Bhatia R, Yenokyan G, Llosa NJ, Ladle BH, Meyer CF, Levin AS, Pratilas CA, Ladra M, Acharya S. Chang L, et al. Among authors: pratilas ca. Int J Radiat Oncol Biol Phys. 2024 Feb 1;118(2):474-484. doi: 10.1016/j.ijrobp.2023.09.007. Epub 2023 Oct 3. Int J Radiat Oncol Biol Phys. 2024. PMID: 37797747
97 results