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Lgr5(+ve) stem cells drive self-renewal in the stomach and build long-lived gastric units in vitro.
Barker N, Huch M, Kujala P, van de Wetering M, Snippert HJ, van Es JH, Sato T, Stange DE, Begthel H, van den Born M, Danenberg E, van den Brink S, Korving J, Abo A, Peters PJ, Wright N, Poulsom R, Clevers H. Barker N, et al. Among authors: stange de. Cell Stem Cell. 2010 Jan 8;6(1):25-36. doi: 10.1016/j.stem.2009.11.013. Cell Stem Cell. 2010. PMID: 20085740 Free article.
Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts.
Sato T, van Es JH, Snippert HJ, Stange DE, Vries RG, van den Born M, Barker N, Shroyer NF, van de Wetering M, Clevers H. Sato T, et al. Among authors: stange de. Nature. 2011 Jan 20;469(7330):415-8. doi: 10.1038/nature09637. Epub 2010 Nov 28. Nature. 2011. PMID: 21113151 Free PMC article.
Transcription factor achaete scute-like 2 controls intestinal stem cell fate.
van der Flier LG, van Gijn ME, Hatzis P, Kujala P, Haegebarth A, Stange DE, Begthel H, van den Born M, Guryev V, Oving I, van Es JH, Barker N, Peters PJ, van de Wetering M, Clevers H. van der Flier LG, et al. Among authors: stange de. Cell. 2009 Mar 6;136(5):903-12. doi: 10.1016/j.cell.2009.01.031. Cell. 2009. PMID: 19269367 Free article.
Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling.
de Lau W, Barker N, Low TY, Koo BK, Li VS, Teunissen H, Kujala P, Haegebarth A, Peters PJ, van de Wetering M, Stange DE, van Es JE, Guardavaccaro D, Schasfoort RB, Mohri Y, Nishimori K, Mohammed S, Heck AJ, Clevers H. de Lau W, et al. Among authors: stange de. Nature. 2011 Jul 4;476(7360):293-7. doi: 10.1038/nature10337. Nature. 2011. PMID: 21727895
67 results