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Page 1
Design and synthesis of tricyclic sulfones as gamma-secretase inhibitors with greatly reduced Notch toxicity.
Xu R, Cole D, Asberom T, Bara T, Bennett C, Burnett DA, Clader J, Domalski M, Greenlee W, Hyde L, Josien H, Li H, McBriar M, McKittrick B, McPhail AT, Pissarnitski D, Qiang L, Rajagopalan M, Sasikumar T, Su J, Tang H, Wu WL, Zhang L, Zhao Z. Xu R, et al. Among authors: mckittrick b. Bioorg Med Chem Lett. 2010 Apr 15;20(8):2591-6. doi: 10.1016/j.bmcl.2010.02.080. Epub 2010 Feb 23. Bioorg Med Chem Lett. 2010. PMID: 20236824
Iminoheterocycles as gamma-secretase modulators.
Caldwell JP, Bennett CE, McCracken TM, Mazzola RD, Bara T, Buevich A, Burnett DA, Chu I, Cohen-Williams M, Josein H, Hyde L, Lee J, McKittrick B, Song L, Terracina G, Voigt J, Zhang L, Zhu Z. Caldwell JP, et al. Among authors: mckittrick b. Bioorg Med Chem Lett. 2010 Sep 15;20(18):5380-4. doi: 10.1016/j.bmcl.2010.07.121. Epub 2010 Aug 1. Bioorg Med Chem Lett. 2010. PMID: 20724152
Generation of Leads for γ-Secretase Modulation.
Mandal M, Buevich A, Caldwell JP, Hyde L, Huang X, Liu X, McKittrick B, Mazzola RD, Pissarnitski D, Palani A, Zhang L, Parker E, Xiao L, Rindgen D, Zhu Z. Mandal M, et al. Among authors: mckittrick b. J Med Chem. 2020 Aug 13;63(15):8216-8230. doi: 10.1021/acs.jmedchem.0c00446. Epub 2020 Aug 4. J Med Chem. 2020. PMID: 32786237
Modification of the clozapine structure by parallel synthesis.
Su J, Tang H, McKittrick BA, Burnett DA, Zhang H, Smith-Torhan A, Fawzi A, Lachowicz J. Su J, et al. Bioorg Med Chem Lett. 2006 Sep 1;16(17):4548-53. doi: 10.1016/j.bmcl.2006.06.034. Epub 2006 Jun 27. Bioorg Med Chem Lett. 2006. PMID: 16806922
2,6-Disubstituted N-arylsulfonyl piperidines as gamma-secretase inhibitors.
Pissarnitski DA, Asberom T, Bara TA, Buevich AV, Clader JW, Greenlee WJ, Guzik HS, Josien HB, Li W, McEwan M, McKittrick BA, Nechuta TL, Parker EM, Sinning L, Smith EM, Song L, Vaccaro HA, Voigt JH, Zhang L, Zhang Q, Zhao Z. Pissarnitski DA, et al. Among authors: mckittrick ba. Bioorg Med Chem Lett. 2007 Jan 1;17(1):57-62. doi: 10.1016/j.bmcl.2006.09.094. Epub 2006 Oct 4. Bioorg Med Chem Lett. 2007. PMID: 17055268
Synthesis of novel bicyclo[4.1.0]heptane and bicyclo[3.1.0]hexane derivatives as melanin-concentrating hormone receptor R1 antagonists.
Su J, Tang H, McKittrick BA, Gu H, Guo T, Qian G, Burnett DA, Clader JW, Greenlee WJ, Hawes BE, O'neill K, Spar B, Weig B, Kowalski T, Sorota S. Su J, et al. Among authors: mckittrick ba. Bioorg Med Chem Lett. 2007 Sep 1;17(17):4845-50. doi: 10.1016/j.bmcl.2007.06.048. Epub 2007 Jun 17. Bioorg Med Chem Lett. 2007. PMID: 17604169
T-type calcium channel blockers: spiro-piperidine azetidines and azetidinones-optimization, design and synthesis.
Smith EM, Sorota S, Kim HM, McKittrick BA, Nechuta TL, Bennett C, Knutson C, Burnett DA, Kieselgof J, Tan Z, Rindgen D, Bridal T, Zhou X, Jia YP, Dong Z, Mullins D, Zhang X, Priestley T, Correll CC, Tulshian D, Czarniecki M, Greenlee WJ. Smith EM, et al. Bioorg Med Chem Lett. 2010 Aug 1;20(15):4602-6. doi: 10.1016/j.bmcl.2010.06.012. Epub 2010 Jun 8. Bioorg Med Chem Lett. 2010. PMID: 20580233
42 results