Copp LJ - Search Results

1

Peptidyl (acyloxy)methyl ketones and the quiescent affinity label concept: the departing group as a variable structural element in the design of inactivators of cysteine proteinases.

Krantz A, Copp LJ, Coles PJ, Smith RA, Heard SB. Krantz A, et al. Among authors: copp lj. Biochemistry. 1991 May 14;30(19):4678-87. doi: 10.1021/bi00233a007. Biochemistry. 1991. PMID: 2029515

2

Inactivation of a cytosolic phospholipase A2 by thiol-modifying reagents: cysteine residues as potential targets of phospholipase A2.

Li B, Copp L, Castelhano AL, Feng R, Stahl M, Yuan Z, Krantz A. Li B, et al. Biochemistry. 1994 Jul 19;33(28):8594-603. doi: 10.1021/bi00194a026. Biochemistry. 1994. PMID: 8031794

3

Peptidyl O-acyl hydroxamates: potent new inactivators of cathepsin B.

Smith RA, Coles PJ, Spencer RW, Copp LJ, Jones CS, Krantz A. Smith RA, et al. Among authors: copp lj. Biochem Biophys Res Commun. 1988 Sep 30;155(3):1201-6. doi: 10.1016/s0006-291x(88)81267-1. Biochem Biophys Res Commun. 1988. PMID: 3178802

4

Inhibition of cathepsin B by peptidyl aldehydes and ketones: slow-binding behavior of a trifluoromethyl ketone.

Smith RA, Copp LJ, Donnelly SL, Spencer RW, Krantz A. Smith RA, et al. Among authors: copp lj. Biochemistry. 1988 Aug 23;27(17):6568-73. doi: 10.1021/bi00417a056. Biochemistry. 1988. PMID: 3219354

5

In vivo inhibition of cathepsin B by peptidyl (acyloxy)methyl ketones.

Wagner BM, Smith RA, Coles PJ, Copp LJ, Ernest MJ, Krantz A. Wagner BM, et al. Among authors: copp lj. J Med Chem. 1994 Jun 10;37(12):1833-40. doi: 10.1021/jm00038a012. J Med Chem. 1994. PMID: 8021922

6

Design and synthesis of 4H-3,1-benzoxazin-4-ones as potent alternate substrate inhibitors of human leukocyte elastase.

Krantz A, Spencer RW, Tam TF, Liak TJ, Copp LJ, Thomas EM, Rafferty SP. Krantz A, et al. Among authors: copp lj. J Med Chem. 1990 Feb;33(2):464-79. doi: 10.1021/jm00164a002. J Med Chem. 1990. PMID: 2299617

7

Kinetics and mechanism of human leukocyte elastase inactivation by ynenol lactones.

Copp LJ, Krantz A, Spencer RW. Copp LJ, et al. Biochemistry. 1987 Jan 13;26(1):169-78. doi: 10.1021/bi00375a024. Biochemistry. 1987. PMID: 3548814

8

Design of alternate substrate inhibitors of serine proteases. Synergistic use of alkyl substitution to impede enzyme-catalyzed deacylation.

Krantz A, Spencer RW, Tam TF, Thomas E, Copp LJ. Krantz A, et al. Among authors: copp lj. J Med Chem. 1987 Apr;30(4):489-91. doi: 10.1021/jm00387a001. J Med Chem. 1987. PMID: 3550086 No abstract available.

9

Inhibition of serine proteases by benzoxazinones: effects of electron withdrawal and 5-substitution.

Spencer RW, Copp LJ, Bonaventura B, Tam TF, Liak TJ, Billedeau RJ, Krantz A. Spencer RW, et al. Among authors: copp lj. Biochem Biophys Res Commun. 1986 Nov 14;140(3):928-33. doi: 10.1016/0006-291x(86)90724-2. Biochem Biophys Res Commun. 1986. PMID: 3535800

10

Inhibition of human leukocyte elastase, porcine pancreatic elastase, and chymotrypsin by elasnin and other 4-hydroxy-2-pyrones.

Spencer RW, Copp LJ, Pfister JR. Spencer RW, et al. Among authors: copp lj. J Med Chem. 1985 Dec;28(12):1828-32. doi: 10.1021/jm00150a013. J Med Chem. 1985. PMID: 4068006

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