Besra G - Search Results

1

Self-poisoning of Mycobacterium tuberculosis by targeting GlgE in an alpha-glucan pathway.

Kalscheuer R, Syson K, Veeraraghavan U, Weinrick B, Biermann KE, Liu Z, Sacchettini JC, Besra G, Bornemann S, Jacobs WR Jr. Kalscheuer R, et al. Among authors: besra g. Nat Chem Biol. 2010 May;6(5):376-84. doi: 10.1038/nchembio.340. Epub 2010 Mar 21. Nat Chem Biol. 2010. PMID: 20305657 Free PMC article.

2

Crystal structure of the secreted form of antigen 85C reveals potential targets for mycobacterial drugs and vaccines.

Ronning DR, Klabunde T, Besra GS, Vissa VD, Belisle JT, Sacchettini JC. Ronning DR, et al. Among authors: besra gs. Nat Struct Biol. 2000 Feb;7(2):141-6. doi: 10.1038/72413. Nat Struct Biol. 2000. PMID: 10655617

3

Thiolactomycin and related analogues as novel anti-mycobacterial agents targeting KasA and KasB condensing enzymes in Mycobacterium tuberculosis.

Kremer L, Douglas JD, Baulard AR, Morehouse C, Guy MR, Alland D, Dover LG, Lakey JH, Jacobs WR Jr, Brennan PJ, Minnikin DE, Besra GS. Kremer L, et al. Among authors: besra gs. J Biol Chem. 2000 Jun 2;275(22):16857-64. doi: 10.1074/jbc.M000569200. J Biol Chem. 2000. PMID: 10747933 Free article.

4

Overexpression of inhA, but not kasA, confers resistance to isoniazid and ethionamide in Mycobacterium smegmatis, M. bovis BCG and M. tuberculosis.

Larsen MH, Vilchèze C, Kremer L, Besra GS, Parsons L, Salfinger M, Heifets L, Hazbon MH, Alland D, Sacchettini JC, Jacobs WR Jr. Larsen MH, et al. Mol Microbiol. 2002 Oct;46(2):453-66. doi: 10.1046/j.1365-2958.2002.03162.x. Mol Microbiol. 2002. PMID: 12406221 Free article.

5

Inhibition of InhA activity, but not KasA activity, induces formation of a KasA-containing complex in mycobacteria.

Kremer L, Dover LG, Morbidoni HR, Vilchèze C, Maughan WN, Baulard A, Tu SC, Honoré N, Deretic V, Sacchettini JC, Locht C, Jacobs WR Jr, Besra GS. Kremer L, et al. Among authors: besra gs. J Biol Chem. 2003 Jun 6;278(23):20547-54. doi: 10.1074/jbc.M302435200. Epub 2003 Mar 24. J Biol Chem. 2003. PMID: 12654922 Free article.

6

Mycobacterium tuberculosis antigen 85A and 85C structures confirm binding orientation and conserved substrate specificity.

Ronning DR, Vissa V, Besra GS, Belisle JT, Sacchettini JC. Ronning DR, et al. J Biol Chem. 2004 Aug 27;279(35):36771-7. doi: 10.1074/jbc.M400811200. Epub 2004 Jun 10. J Biol Chem. 2004. PMID: 15192106 Free article.

7

Mycobacterium tuberculosis pks12 produces a novel polyketide presented by CD1c to T cells.

Matsunaga I, Bhatt A, Young DC, Cheng TY, Eyles SJ, Besra GS, Briken V, Porcelli SA, Costello CE, Jacobs WR Jr, Moody DB. Matsunaga I, et al. J Exp Med. 2004 Dec 20;200(12):1559-69. doi: 10.1084/jem.20041429. J Exp Med. 2004. PMID: 15611286 Free PMC article.

8

Probing the mechanism of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III mtFabH: factors influencing catalysis and substrate specificity.

Brown AK, Sridharan S, Kremer L, Lindenberg S, Dover LG, Sacchettini JC, Besra GS. Brown AK, et al. Among authors: besra gs. J Biol Chem. 2005 Sep 16;280(37):32539-47. doi: 10.1074/jbc.M413216200. Epub 2005 Jul 22. J Biol Chem. 2005. PMID: 16040614 Free article.

9

X-ray crystal structure of Mycobacterium tuberculosis beta-ketoacyl acyl carrier protein synthase II (mtKasB).

Sridharan S, Wang L, Brown AK, Dover LG, Kremer L, Besra GS, Sacchettini JC. Sridharan S, et al. Among authors: besra gs. J Mol Biol. 2007 Feb 16;366(2):469-80. doi: 10.1016/j.jmb.2006.11.006. Epub 2006 Nov 7. J Mol Biol. 2007. PMID: 17174327 Free PMC article.

10

Mechanism of thioamide drug action against tuberculosis and leprosy.

Wang F, Langley R, Gulten G, Dover LG, Besra GS, Jacobs WR Jr, Sacchettini JC. Wang F, et al. Among authors: besra gs. J Exp Med. 2007 Jan 22;204(1):73-8. doi: 10.1084/jem.20062100. Epub 2007 Jan 16. J Exp Med. 2007. PMID: 17227913 Free PMC article.

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