Marshall J - Search Results

1

Improved management of lysosomal glucosylceramide levels in a mouse model of type 1 Gaucher disease using enzyme and substrate reduction therapy.

Marshall J, McEachern KA, Chuang WL, Hutto E, Siegel CS, Shayman JA, Grabowski GA, Scheule RK, Copeland DP, Cheng SH. Marshall J, et al. J Inherit Metab Dis. 2010 Jun;33(3):281-9. doi: 10.1007/s10545-010-9072-z. Epub 2010 Mar 25. J Inherit Metab Dis. 2010. PMID: 20336375 Free PMC article.

2

Demonstration of feasibility of in vivo gene therapy for Gaucher disease using a chemically induced mouse model.

Marshall J, McEachern KA, Kyros JA, Nietupski JB, Budzinski T, Ziegler RJ, Yew NS, Sullivan J, Scaria A, van Rooijen N, Barranger JA, Cheng SH. Marshall J, et al. Mol Ther. 2002 Aug;6(2):179-89. doi: 10.1006/mthe.2002.0650. Mol Ther. 2002. PMID: 12161184 Free article.

3

AAV8-mediated expression of glucocerebrosidase ameliorates the storage pathology in the visceral organs of a mouse model of Gaucher disease.

McEachern KA, Nietupski JB, Chuang WL, Armentano D, Johnson J, Hutto E, Grabowski GA, Cheng SH, Marshall J. McEachern KA, et al. Among authors: marshall j. J Gene Med. 2006 Jun;8(6):719-29. doi: 10.1002/jgm.901. J Gene Med. 2006. PMID: 16528760

4

A specific and potent inhibitor of glucosylceramide synthase for substrate inhibition therapy of Gaucher disease.

McEachern KA, Fung J, Komarnitsky S, Siegel CS, Chuang WL, Hutto E, Shayman JA, Grabowski GA, Aerts JM, Cheng SH, Copeland DP, Marshall J. McEachern KA, et al. Among authors: marshall j. Mol Genet Metab. 2007 Jul;91(3):259-67. doi: 10.1016/j.ymgme.2007.04.001. Epub 2007 May 16. Mol Genet Metab. 2007. PMID: 17509920

5

Substrate reduction augments the efficacy of enzyme therapy in a mouse model of Fabry disease.

Marshall J, Ashe KM, Bangari D, McEachern K, Chuang WL, Pacheco J, Copeland DP, Desnick RJ, Shayman JA, Scheule RK, Cheng SH. Marshall J, et al. PLoS One. 2010 Nov 24;5(11):e15033. doi: 10.1371/journal.pone.0015033. PLoS One. 2010. PMID: 21124789 Free PMC article.

6

Iminosugar-based inhibitors of glucosylceramide synthase increase brain glycosphingolipids and survival in a mouse model of Sandhoff disease.

Ashe KM, Bangari D, Li L, Cabrera-Salazar MA, Bercury SD, Nietupski JB, Cooper CG, Aerts JM, Lee ER, Copeland DP, Cheng SH, Scheule RK, Marshall J. Ashe KM, et al. Among authors: marshall j. PLoS One. 2011;6(6):e21758. doi: 10.1371/journal.pone.0021758. Epub 2011 Jun 29. PLoS One. 2011. PMID: 21738789 Free PMC article.

7

Iminosugar-based inhibitors of glucosylceramide synthase prolong survival but paradoxically increase brain glucosylceramide levels in Niemann-Pick C mice.

Nietupski JB, Pacheco JJ, Chuang WL, Maratea K, Li L, Foley J, Ashe KM, Cooper CG, Aerts JM, Copeland DP, Scheule RK, Cheng SH, Marshall J. Nietupski JB, et al. Among authors: marshall j. Mol Genet Metab. 2012 Apr;105(4):621-8. doi: 10.1016/j.ymgme.2012.01.020. Epub 2012 Feb 1. Mol Genet Metab. 2012. PMID: 22366055

8

Efficacy of Enzyme and Substrate Reduction Therapy with a Novel Antagonist of Glucosylceramide Synthase for Fabry Disease.

Ashe KM, Budman E, Bangari DS, Siegel CS, Nietupski JB, Wang B, Desnick RJ, Scheule RK, Leonard JP, Cheng SH, Marshall J. Ashe KM, et al. Among authors: marshall j. Mol Med. 2015 Apr 30;21(1):389-99. doi: 10.2119/molmed.2015.00088. Mol Med. 2015. PMID: 25938659 Free PMC article.

9

Intracerebroventricular delivery of glucocerebrosidase reduces substrates and increases lifespan in a mouse model of neuronopathic Gaucher disease.

Cabrera-Salazar MA, Bercury SD, Ziegler RJ, Marshall J, Hodges BL, Chuang WL, Pacheco J, Li L, Cheng SH, Scheule RK. Cabrera-Salazar MA, et al. Among authors: marshall j. Exp Neurol. 2010 Oct;225(2):436-44. doi: 10.1016/j.expneurol.2010.07.023. Epub 2010 Jul 29. Exp Neurol. 2010. PMID: 20673762

10

Formulation of synthetic vectors for cystic fibrosis gene therapy.

Marshall J, Cheng SH. Marshall J, et al. Methods Mol Med. 2002;70:585-98. doi: 10.1385/1-59259-187-6:585. Methods Mol Med. 2002. PMID: 11917553 No abstract available.

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