Siegel CS - Search Results

1

Improved management of lysosomal glucosylceramide levels in a mouse model of type 1 Gaucher disease using enzyme and substrate reduction therapy.

Marshall J, McEachern KA, Chuang WL, Hutto E, Siegel CS, Shayman JA, Grabowski GA, Scheule RK, Copeland DP, Cheng SH. Marshall J, et al. Among authors: siegel cs. J Inherit Metab Dis. 2010 Jun;33(3):281-9. doi: 10.1007/s10545-010-9072-z. Epub 2010 Mar 25. J Inherit Metab Dis. 2010. PMID: 20336375 Free PMC article.

2

A specific and potent inhibitor of glucosylceramide synthase for substrate inhibition therapy of Gaucher disease.

McEachern KA, Fung J, Komarnitsky S, Siegel CS, Chuang WL, Hutto E, Shayman JA, Grabowski GA, Aerts JM, Cheng SH, Copeland DP, Marshall J. McEachern KA, et al. Among authors: siegel cs. Mol Genet Metab. 2007 Jul;91(3):259-67. doi: 10.1016/j.ymgme.2007.04.001. Epub 2007 May 16. Mol Genet Metab. 2007. PMID: 17509920

3

Efficacy of Enzyme and Substrate Reduction Therapy with a Novel Antagonist of Glucosylceramide Synthase for Fabry Disease.

Ashe KM, Budman E, Bangari DS, Siegel CS, Nietupski JB, Wang B, Desnick RJ, Scheule RK, Leonard JP, Cheng SH, Marshall J. Ashe KM, et al. Among authors: siegel cs. Mol Med. 2015 Apr 30;21(1):389-99. doi: 10.2119/molmed.2015.00088. Mol Med. 2015. PMID: 25938659 Free PMC article.

4

Increased hepatic insulin action in diet-induced obese mice following inhibition of glucosylceramide synthase.

Yew NS, Zhao H, Hong EG, Wu IH, Przybylska M, Siegel C, Shayman JA, Arbeeny CM, Kim JK, Jiang C, Cheng SH. Yew NS, et al. PLoS One. 2010 Jun 21;5(6):e11239. doi: 10.1371/journal.pone.0011239. PLoS One. 2010. PMID: 20574539 Free PMC article.

5

Lowering glycosphingolipid levels in CD4+ T cells attenuates T cell receptor signaling, cytokine production, and differentiation to the Th17 lineage.

Zhu Y, Gumlaw N, Karman J, Zhao H, Zhang J, Jiang JL, Maniatis P, Edling A, Chuang WL, Siegel C, Shayman JA, Kaplan J, Jiang C, Cheng SH. Zhu Y, et al. J Biol Chem. 2011 Apr 29;286(17):14787-94. doi: 10.1074/jbc.M111.218610. Epub 2011 Mar 14. J Biol Chem. 2011. PMID: 21402703 Free PMC article.

6

Inhibiting glycosphingolipid synthesis improves glycemic control and insulin sensitivity in animal models of type 2 diabetes.

Zhao H, Przybylska M, Wu IH, Zhang J, Siegel C, Komarnitsky S, Yew NS, Cheng SH. Zhao H, et al. Diabetes. 2007 May;56(5):1210-8. doi: 10.2337/db06-0719. Diabetes. 2007. PMID: 17470562

7

Cationic lipid structure and formulation considerations for optimal gene transfection of the lung.

Marshall J, Nietupski JB, Lee ER, Siegel CS, Rafter PW, Rudginsky SA, Chang CD, Eastman SJ, Harris DJ, Scheule RK, Cheng SH. Marshall J, et al. Among authors: siegel cs. J Drug Target. 2000;7(6):453-69. doi: 10.3109/10611860009102219. J Drug Target. 2000. PMID: 10758915

8

Reducing glycosphingolipid biosynthesis in airway cells partially ameliorates disease manifestations in a mouse model of asthma.

Karman J, Tedstone JL, Gumlaw NK, Zhu Y, Yew N, Siegel C, Guo S, Siwkowski A, Ruzek M, Jiang C, Cheng SH. Karman J, et al. Int Immunol. 2010 Jul;22(7):593-603. doi: 10.1093/intimm/dxq044. Epub 2010 May 24. Int Immunol. 2010. PMID: 20497953

9

Biophysical characterization of cationic lipid: DNA complexes.

Eastman SJ, Siegel C, Tousignant J, Smith AE, Cheng SH, Scheule RK. Eastman SJ, et al. Biochim Biophys Acta. 1997 Apr 3;1325(1):41-62. doi: 10.1016/s0005-2736(96)00242-8. Biochim Biophys Acta. 1997. PMID: 9106482 Free article.

10

Detailed analysis of structures and formulations of cationic lipids for efficient gene transfer to the lung.

Lee ER, Marshall J, Siegel CS, Jiang C, Yew NS, Nichols MR, Nietupski JB, Ziegler RJ, Lane MB, Wang KX, Wan NC, Scheule RK, Harris DJ, Smith AE, Cheng SH. Lee ER, et al. Among authors: siegel cs. Hum Gene Ther. 1996 Sep 10;7(14):1701-17. doi: 10.1089/hum.1996.7.14-1701. Hum Gene Ther. 1996. PMID: 8886841

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