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Discovery of DS-6930, a potent selective PPARγ modulator. Part II: Lead optimization.
Shinozuka T, Tsukada T, Fujii K, Tokumaru E, Shimada K, Onishi Y, Matsui Y, Wakimoto S, Kuroha M, Ogata T, Araki K, Ohsumi J, Sawamura R, Watanabe N, Yamamoto H, Fujimoto K, Tani Y, Mori M, Tanaka J. Shinozuka T, et al. Among authors: tsukada t. Bioorg Med Chem. 2018 Oct 1;26(18):5099-5117. doi: 10.1016/j.bmc.2018.09.005. Epub 2018 Sep 8. Bioorg Med Chem. 2018. PMID: 30220602
Discovery of DS-6930, a potent selective PPARγ modulator. Part I: Lead identification.
Shinozuka T, Tsukada T, Fujii K, Tokumaru E, Shimada K, Onishi Y, Matsui Y, Wakimoto S, Kuroha M, Ogata T, Araki K, Ohsumi J, Sawamura R, Watanabe N, Yamamoto H, Fujimoto K, Tani Y, Mori M, Tanaka J. Shinozuka T, et al. Among authors: tsukada t. Bioorg Med Chem. 2018 Oct 1;26(18):5079-5098. doi: 10.1016/j.bmc.2018.09.006. Epub 2018 Sep 8. Bioorg Med Chem. 2018. PMID: 30241907
Structure-Activity Relationship Studies of 3- or 4-Pyridine Derivatives of DS-6930.
Shinozuka T, Tsukada T, Fujii K, Tokumaru E, Matsui Y, Wakimoto S, Ogata T, Araki K, Sawamura R, Watanabe N, Mori M, Tanaka J. Shinozuka T, et al. Among authors: tsukada t. ACS Med Chem Lett. 2019 Feb 26;10(3):358-362. doi: 10.1021/acsmedchemlett.8b00645. eCollection 2019 Mar 14. ACS Med Chem Lett. 2019. PMID: 30891140 Free PMC article.
Novel protein kinase cAMP-Activated Catalytic Subunit Alpha (PRKACA) inhibitor shows anti-tumor activity in a fibrolamellar hepatocellular carcinoma model.
Toyota A, Goto M, Miyamoto M, Nagashima Y, Iwasaki S, Komatsu T, Momose T, Yoshida K, Tsukada T, Matsufuji T, Ohno A, Suzuki M, Ubukata O, Kaneta Y. Toyota A, et al. Among authors: tsukada t. Biochem Biophys Res Commun. 2022 Sep 17;621:157-161. doi: 10.1016/j.bbrc.2022.07.008. Epub 2022 Jul 7. Biochem Biophys Res Commun. 2022. PMID: 35839742
752 results