Halladay JS - Search Results

1

Formation of a quinoneimine intermediate of 4-fluoro-N-methylaniline by FMO1: carbon oxidation plus defluorination.

Driscoll JP, Aliagas I, Harris JJ, Halladay JS, Khatib-Shahidi S, Deese A, Segraves N, Khojasteh-Bakht SC. Driscoll JP, et al. Among authors: halladay js. Chem Res Toxicol. 2010 May 17;23(5):861-3. doi: 10.1021/tx1000688. Chem Res Toxicol. 2010. PMID: 20369854

2

Metabolic stability screen for drug discovery using cassette analysis and column switching.

Halladay JS, Wong S, Jaffer SM, Sinhababu AK, Khojasteh-Bakht SC. Halladay JS, et al. Drug Metab Lett. 2007 Jan;1(1):67-72. doi: 10.2174/187231207779814364. Drug Metab Lett. 2007. PMID: 19356021

3

Inhibitory properties of trapping agents: glutathione, potassium cyanide, and methoxylamine, against major human cytochrome p450 isoforms.

Zhang C, Wong S, Delarosa EM, Kenny JR, Halladay JS, Hop CE, Khojasteh-Bakht SC. Zhang C, et al. Among authors: halladay js. Drug Metab Lett. 2009 Apr;3(2):125-9. doi: 10.2174/187231209788654126. Drug Metab Lett. 2009. PMID: 19601875

4

Significant species difference in amide hydrolysis of GDC-0834, a novel potent and selective Bruton's tyrosine kinase inhibitor.

Liu L, Halladay JS, Shin Y, Wong S, Coraggio M, La H, Baumgardner M, Le H, Gopaul S, Boggs J, Kuebler P, Davis JC Jr, Liao XC, Lubach JW, Deese A, Sowell CG, Currie KS, Young WB, Khojasteh SC, Hop CE, Wong H. Liu L, et al. Among authors: halladay js. Drug Metab Dispos. 2011 Oct;39(10):1840-9. doi: 10.1124/dmd.111.040840. Epub 2011 Jul 8. Drug Metab Dispos. 2011. PMID: 21742900

5

Novel mechanism for dehalogenation and glutathione conjugation of dihalogenated anilines in human liver microsomes: evidence for ipso glutathione addition.

Zhang C, Kenny JR, Le H, Deese A, Ford KA, Lightning LK, Fan PW, Driscoll JP, Halladay JS, Hop CE, Khojasteh SC. Zhang C, et al. Among authors: halladay js. Chem Res Toxicol. 2011 Oct 17;24(10):1668-77. doi: 10.1021/tx2002228. Epub 2011 Sep 25. Chem Res Toxicol. 2011. PMID: 21905702

6

Lead identification of novel and selective TYK2 inhibitors.

Liang J, Tsui V, Van Abbema A, Bao L, Barrett K, Beresini M, Berezhkovskiy L, Blair WS, Chang C, Driscoll J, Eigenbrot C, Ghilardi N, Gibbons P, Halladay J, Johnson A, Kohli PB, Lai Y, Liimatta M, Mantik P, Menghrajani K, Murray J, Sambrone A, Xiao Y, Shia S, Shin Y, Smith J, Sohn S, Stanley M, Ultsch M, Zhang B, Wu LC, Magnuson S. Liang J, et al. Eur J Med Chem. 2013 Sep;67:175-87. doi: 10.1016/j.ejmech.2013.03.070. Epub 2013 May 14. Eur J Med Chem. 2013. PMID: 23867602

7

Going Beyond Common Drug Metabolizing Enzymes: Case Studies of Biotransformation Involving Aldehyde Oxidase, γ-Glutamyl Transpeptidase, Cathepsin B, Flavin-Containing Monooxygenase, and ADP-Ribosyltransferase.

Fan PW, Zhang D, Halladay JS, Driscoll JP, Khojasteh SC. Fan PW, et al. Among authors: halladay js. Drug Metab Dispos. 2016 Aug;44(8):1253-61. doi: 10.1124/dmd.116.070169. Epub 2016 Apr 26. Drug Metab Dispos. 2016. PMID: 27117704 Review.

8

Inhibitory Effects of Trapping Agents of Sulfur Drug Reactive Intermediates against Major Human Cytochrome P450 Isoforms.

Sodhi JK, Delarosa EM, Halladay JS, Driscoll JP, Mulder T, Dansette PM, Khojasteh SC. Sodhi JK, et al. Among authors: halladay js. Int J Mol Sci. 2017 Jul 20;18(7):1553. doi: 10.3390/ijms18071553. Int J Mol Sci. 2017. PMID: 28726718 Free PMC article.

9

High-throughput, 384-well, LC-MS/MS CYP inhibition assay using automation, cassette-analysis technique, and streamlined data analysis.

Halladay JS, Delarosa EM, Tran D, Wang L, Wong S, Khojasteh SC. Halladay JS, et al. Drug Metab Lett. 2011 Aug;5(3):220-30. Drug Metab Lett. 2011. PMID: 21867481

10

1-Aminobenzotriazole coincubated with (S)-warfarin results in potent inactivation of CYP2C9.

Sodhi JK, Ford KA, Mukadam S, Wong S, Hop CE, Khojasteh SC, Halladay JS. Sodhi JK, et al. Among authors: halladay js. Drug Metab Dispos. 2014 May;42(5):813-7. doi: 10.1124/dmd.113.055913. Epub 2014 Feb 18. Drug Metab Dispos. 2014. PMID: 24550229

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