Vanhoof G - Search Results

1

Effects of phosphodiesterase 10 inhibition on striatal cyclic AMP and peripheral physiology in rats.

Torremans A, Ahnaou A, Van Hemelrijck A, Straetemans R, Geys H, Vanhoof G, Meert TF, Drinkenburg WH. Torremans A, et al. Among authors: vanhoof g. Acta Neurobiol Exp (Wars). 2010;70(1):13-9. doi: 10.55782/ane-2010-1769. Acta Neurobiol Exp (Wars). 2010. PMID: 20407482 Free article.

2

Selective D1 agonism but not D2 antagonism is reflected in cAMP and cGMP levels in rat CSF.

Torremans A, Van Hemelrijck A, Straetemans R, Vanhoof G, Van Den Kieboom G, Drinkenburg WH. Torremans A, et al. Among authors: vanhoof g. Brain Res Bull. 2010 Apr 5;81(6):549-51. doi: 10.1016/j.brainresbull.2009.12.004. Epub 2009 Dec 14. Brain Res Bull. 2010. PMID: 20015466

3

Impaired appetitively as well as aversively motivated behaviors and learning in PDE10A-deficient mice suggest a role for striatal signaling in evaluative salience attribution.

Piccart E, Gantois I, Laeremans A, de Hoogt R, Meert T, Vanhoof G, Arckens L, D'Hooge R. Piccart E, et al. Among authors: vanhoof g. Neurobiol Learn Mem. 2011 Mar;95(3):260-9. doi: 10.1016/j.nlm.2010.11.018. Epub 2010 Dec 2. Neurobiol Learn Mem. 2011. PMID: 21130175

4

Selective inhibition of phosphodiesterase 10A impairs appetitive and aversive conditioning and incentive salience attribution.

Piccart E, Langlois X, Vanhoof G, D'Hooge R. Piccart E, et al. Among authors: vanhoof g. Neuropharmacology. 2013 Dec;75:437-44. doi: 10.1016/j.neuropharm.2013.08.006. Epub 2013 Aug 22. Neuropharmacology. 2013. PMID: 23973318

5

Pharmacology of JNJ-42314415, a centrally active phosphodiesterase 10A (PDE10A) inhibitor: a comparison of PDE10A inhibitors with D2 receptor blockers as potential antipsychotic drugs.

Megens AA, Hendrickx HM, Hens KA, Fonteyn I, Langlois X, Lenaerts I, Somers MV, de Boer P, Vanhoof G. Megens AA, et al. Among authors: vanhoof g. J Pharmacol Exp Ther. 2014 Apr;349(1):138-54. doi: 10.1124/jpet.113.211904. Epub 2014 Jan 13. J Pharmacol Exp Ther. 2014. PMID: 24421319

6

Striatal phosphodiesterase 10A availability is altered secondary to chronic changes in dopamine neurotransmission.

Ooms M, Celen S, De Hoogt R, Lenaerts I, Liebregts J, Vanhoof G, Langlois X, Postnov A, Koole M, Verbruggen A, Van Laere K, Bormans G. Ooms M, et al. Among authors: vanhoof g. EJNMMI Radiopharm Chem. 2017;1(1):3. doi: 10.1186/s41181-016-0005-5. Epub 2016 Mar 21. EJNMMI Radiopharm Chem. 2017. PMID: 29564380 Free PMC article.

7

Evaluation of PET radioligands for in vivo visualization of phosphodiesterase 5 (PDE5).

Chekol R, Gheysens O, Cleynhens J, Pokreisz P, Vanhoof G, Ahamed M, Janssens S, Verbruggen A, Bormans G. Chekol R, et al. Among authors: vanhoof g. Nucl Med Biol. 2014 Feb;41(2):155-62. doi: 10.1016/j.nucmedbio.2013.10.007. Epub 2013 Oct 30. Nucl Med Biol. 2014. PMID: 24290227

8

Discovery of a potent, selective, and orally active phosphodiesterase 10A inhibitor for the potential treatment of schizophrenia.

Bartolomé-Nebreda JM, Delgado F, Martín-Martín ML, Martínez-Viturro CM, Pastor J, Tong HM, Iturrino L, Macdonald GJ, Sanderson W, Megens A, Langlois X, Somers M, Vanhoof G, Conde-Ceide S. Bartolomé-Nebreda JM, et al. Among authors: vanhoof g. J Med Chem. 2014 May 22;57(10):4196-212. doi: 10.1021/jm500073h. Epub 2014 May 9. J Med Chem. 2014. PMID: 24758746

9

Carbon-11 and Fluorine-18 Radiolabeled Pyridopyrazinone Derivatives for Positron Emission Tomography (PET) Imaging of Phosphodiesterase-5 (PDE5).

Chekol R, Gheysens O, Ahamed M, Cleynhens J, Pokreisz P, Vanhoof G, Janssens S, Verbruggen A, Bormans G. Chekol R, et al. Among authors: vanhoof g. J Med Chem. 2017 Jan 12;60(1):486-496. doi: 10.1021/acs.jmedchem.6b01666. Epub 2016 Dec 23. J Med Chem. 2017. PMID: 28009175

10

PDE10A inhibitors stimulate or suppress motor behavior dependent on the relative activation state of the direct and indirect striatal output pathways.

Megens AA, Hendrickx HM, Mahieu MM, Wellens AL, de Boer P, Vanhoof G. Megens AA, et al. Among authors: vanhoof g. Pharmacol Res Perspect. 2014 Aug;2(4):e00057. doi: 10.1002/prp2.57. Epub 2014 Jun 12. Pharmacol Res Perspect. 2014. PMID: 25505601 Free PMC article.

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