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Probing the molecular mechanism of interaction between 4-n-butyl-1-[4-(2-methylphenyl)-4-oxo-1-butyl]-piperidine (AC-42) and the muscarinic M(1) receptor: direct pharmacological evidence that AC-42 is an allosteric agonist.
Langmead CJ, Fry VA, Forbes IT, Branch CL, Christopoulos A, Wood MD, Herdon HJ. Langmead CJ, et al. Among authors: herdon hj. Mol Pharmacol. 2006 Jan;69(1):236-46. doi: 10.1124/mol.105.017814. Epub 2005 Oct 5. Mol Pharmacol. 2006. PMID: 16207821
Characterization of a CNS penetrant, selective M1 muscarinic receptor agonist, 77-LH-28-1.
Langmead CJ, Austin NE, Branch CL, Brown JT, Buchanan KA, Davies CH, Forbes IT, Fry VA, Hagan JJ, Herdon HJ, Jones GA, Jeggo R, Kew JN, Mazzali A, Melarange R, Patel N, Pardoe J, Randall AD, Roberts C, Roopun A, Starr KR, Teriakidis A, Wood MD, Whittington M, Wu Z, Watson J. Langmead CJ, et al. Among authors: herdon hj. Br J Pharmacol. 2008 Jul;154(5):1104-15. doi: 10.1038/bjp.2008.152. Epub 2008 May 5. Br J Pharmacol. 2008. PMID: 18454168 Free PMC article.
39 results