Tehan BG - Search Results

1

Orthosteric and allosteric modes of interaction of novel selective agonists of the M1 muscarinic acetylcholine receptor.

Avlani VA, Langmead CJ, Guida E, Wood MD, Tehan BG, Herdon HJ, Watson JM, Sexton PM, Christopoulos A. Avlani VA, et al. Among authors: tehan bg. Mol Pharmacol. 2010 Jul;78(1):94-104. doi: 10.1124/mol.110.064345. Epub 2010 Apr 22. Mol Pharmacol. 2010. PMID: 20413650

2

Roof and floor of the muscarinic binding pocket: variations in the binding modes of orthosteric ligands.

Goodwin JA, Hulme EC, Langmead CJ, Tehan BG. Goodwin JA, et al. Among authors: tehan bg. Mol Pharmacol. 2007 Dec;72(6):1484-96. doi: 10.1124/mol.107.038265. Epub 2007 Sep 11. Mol Pharmacol. 2007. PMID: 17848601

3

Mutagenic mapping suggests a novel binding mode for selective agonists of M1 muscarinic acetylcholine receptors.

Lebon G, Langmead CJ, Tehan BG, Hulme EC. Lebon G, et al. Among authors: tehan bg. Mol Pharmacol. 2009 Feb;75(2):331-41. doi: 10.1124/mol.108.050963. Epub 2008 Nov 11. Mol Pharmacol. 2009. PMID: 19001633 Free PMC article.

4

From structure to clinic: Design of a muscarinic M1 receptor agonist with potential to treatment of Alzheimer's disease.

Brown AJH, Bradley SJ, Marshall FH, Brown GA, Bennett KA, Brown J, Cansfield JE, Cross DM, de Graaf C, Hudson BD, Dwomoh L, Dias JM, Errey JC, Hurrell E, Liptrot J, Mattedi G, Molloy C, Nathan PJ, Okrasa K, Osborne G, Patel JC, Pickworth M, Robertson N, Shahabi S, Bundgaard C, Phillips K, Broad LM, Goonawardena AV, Morairty SR, Browning M, Perini F, Dawson GR, Deakin JFW, Smith RT, Sexton PM, Warneck J, Vinson M, Tasker T, Tehan BG, Teobald B, Christopoulos A, Langmead CJ, Jazayeri A, Cooke RM, Rucktooa P, Congreve MS, Weir M, Tobin AB. Brown AJH, et al. Among authors: tehan bg. Cell. 2021 Nov 24;184(24):5886-5901.e22. doi: 10.1016/j.cell.2021.11.001. Cell. 2021. PMID: 34822784 Free PMC article. Clinical Trial.

5

Pharmacology and structure of isolated conformations of the adenosine A₂A receptor define ligand efficacy.

Bennett KA, Tehan B, Lebon G, Tate CG, Weir M, Marshall FH, Langmead CJ. Bennett KA, et al. Mol Pharmacol. 2013 May;83(5):949-58. doi: 10.1124/mol.112.084509. Epub 2013 Feb 19. Mol Pharmacol. 2013. PMID: 23429888 Free PMC article.

6

Novel N-Substituted Benzimidazolones as Potent, Selective, CNS-Penetrant, and Orally Active M1 mAChR Agonists.

Budzik B, Garzya V, Shi D, Walker G, Woolley-Roberts M, Pardoe J, Lucas A, Tehan B, Rivero RA, Langmead CJ, Watson J, Wu Z, Forbes IT, Jin J. Budzik B, et al. ACS Med Chem Lett. 2010 Jun 8;1(6):244-8. doi: 10.1021/ml100105x. eCollection 2010 Sep 9. ACS Med Chem Lett. 2010. PMID: 24900202 Free PMC article.

7

Discovery of 1,2,4-triazine derivatives as adenosine A(2A) antagonists using structure based drug design.

Congreve M, Andrews SP, Doré AS, Hollenstein K, Hurrell E, Langmead CJ, Mason JS, Ng IW, Tehan B, Zhukov A, Weir M, Marshall FH. Congreve M, et al. J Med Chem. 2012 Mar 8;55(5):1898-903. doi: 10.1021/jm201376w. Epub 2012 Jan 27. J Med Chem. 2012. PMID: 22220592 Free PMC article.

8

Selective Negative Allosteric Modulation Of Metabotropic Glutamate Receptors – A Structural Perspective of Ligands and Mutants.

Harpsøe K, Isberg V, Tehan BG, Weiss D, Arsova A, Marshall FH, Bräuner-Osborne H, Gloriam DE. Harpsøe K, et al. Among authors: tehan bg. Sci Rep. 2015 Sep 11;5:13869. doi: 10.1038/srep13869. Sci Rep. 2015. PMID: 26359761 Free PMC article.

9

Structural insight into allosteric modulation of protease-activated receptor 2.

Cheng RKY, Fiez-Vandal C, Schlenker O, Edman K, Aggeler B, Brown DG, Brown GA, Cooke RM, Dumelin CE, Doré AS, Geschwindner S, Grebner C, Hermansson NO, Jazayeri A, Johansson P, Leong L, Prihandoko R, Rappas M, Soutter H, Snijder A, Sundström L, Tehan B, Thornton P, Troast D, Wiggin G, Zhukov A, Marshall FH, Dekker N. Cheng RKY, et al. Nature. 2017 May 4;545(7652):112-115. doi: 10.1038/nature22309. Epub 2017 Apr 26. Nature. 2017. PMID: 28445455

10

Structure-based discovery and development of metabotropic glutamate receptor 5 negative allosteric modulators.

Bennett KA, Christopher JA, Tehan BG. Bennett KA, et al. Among authors: tehan bg. Adv Pharmacol. 2020;88:35-58. doi: 10.1016/bs.apha.2020.03.001. Epub 2020 Mar 25. Adv Pharmacol. 2020. PMID: 32416871 Review.

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