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Combined use of ordered mesoporous silica and precipitation inhibitors for improved oral absorption of the poorly soluble weak base itraconazole.
Van Speybroeck M, Mols R, Mellaerts R, Thi TD, Martens JA, Van Humbeeck J, Annaert P, Van den Mooter G, Augustijns P. Van Speybroeck M, et al. Among authors: van humbeeck j, van den mooter g. Eur J Pharm Biopharm. 2010 Aug;75(3):354-65. doi: 10.1016/j.ejpb.2010.04.009. Epub 2010 Apr 24. Eur J Pharm Biopharm. 2010. PMID: 20420905
Ordered mesoporous silica induces pH-independent supersaturation of the basic low solubility compound itraconazole resulting in enhanced transepithelial transport.
Mellaerts R, Mols R, Kayaert P, Annaert P, Van Humbeeck J, Van den Mooter G, Martens JA, Augustijns P. Mellaerts R, et al. Among authors: van humbeeck j, van den mooter g. Int J Pharm. 2008 Jun 5;357(1-2):169-79. doi: 10.1016/j.ijpharm.2008.01.049. Epub 2008 Feb 3. Int J Pharm. 2008. PMID: 18325700
Microcrystalline cellulose, a useful alternative for sucrose as a matrix former during freeze-drying of drug nanosuspensions - a case study with itraconazole.
Van Eerdenbrugh B, Vercruysse S, Martens JA, Vermant J, Froyen L, Van Humbeeck J, Van den Mooter G, Augustijns P. Van Eerdenbrugh B, et al. Among authors: van humbeeck j, van den mooter g. Eur J Pharm Biopharm. 2008 Oct;70(2):590-6. doi: 10.1016/j.ejpb.2008.06.007. Epub 2008 Jun 18. Eur J Pharm Biopharm. 2008. PMID: 18602992
Physical state of poorly water soluble therapeutic molecules loaded into SBA-15 ordered mesoporous silica carriers: a case study with itraconazole and ibuprofen.
Mellaerts R, Jammaer JA, Van Speybroeck M, Chen H, Van Humbeeck J, Augustijns P, Van den Mooter G, Martens JA. Mellaerts R, et al. Among authors: van speybroeck m, van humbeeck j, van den mooter g. Langmuir. 2008 Aug 19;24(16):8651-9. doi: 10.1021/la801161g. Epub 2008 Jul 17. Langmuir. 2008. PMID: 18630936
Itraconazole/TPGS/Aerosil200 solid dispersions: characterization, physical stability and in vivo performance.
Van Eerdenbrugh B, Van Speybroeck M, Mols R, Houthoofd K, Martens JA, Froyen L, Van Humbeeck J, Augustijns P, Van den Mooter G. Van Eerdenbrugh B, et al. Among authors: van speybroeck m, van humbeeck j, van den mooter g. Eur J Pharm Sci. 2009 Oct 8;38(3):270-8. doi: 10.1016/j.ejps.2009.08.002. Epub 2009 Aug 15. Eur J Pharm Sci. 2009. PMID: 19686846
The conflict between in vitro release studies in human biorelevant media and the in vivo exposure in rats of the lipophilic compound fenofibrate.
Do TT, Van Speybroeck M, Mols R, Annaert P, Martens J, Van Humbeeck J, Vermant J, Augustijns P, Van den Mooter G. Do TT, et al. Among authors: van speybroeck m, van humbeeck j, van den mooter g. Int J Pharm. 2011 Jul 29;414(1-2):118-24. doi: 10.1016/j.ijpharm.2011.05.009. Epub 2011 May 7. Int J Pharm. 2011. PMID: 21596119
45 results