Grubb DR - Search Results

1

Potential treatment of cardiac hypertrophy and heart failure by inhibiting the sarcolemmal binding of phospholipase Cbeta1b.

Woodcock EA, Grubb DR, Iliades P. Woodcock EA, et al. Among authors: grubb dr. Curr Drug Targets. 2010 Aug;11(8):1032-40. doi: 10.2174/138945010791591331. Curr Drug Targets. 2010. PMID: 20426766 Review.

2

The extreme C-terminal region of phospholipase Cbeta1 determines subcellular localization and function; the "b" splice variant mediates alpha1-adrenergic receptor responses in cardiomyocytes.

Grubb DR, Vasilevski O, Huynh H, Woodcock EA. Grubb DR, et al. FASEB J. 2008 Aug;22(8):2768-74. doi: 10.1096/fj.07-102558. Epub 2008 Apr 7. FASEB J. 2008. PMID: 18390926

3

Gq-initiated cardiomyocyte hypertrophy is mediated by phospholipase Cbeta1b.

Filtz TM, Grubb DR, McLeod-Dryden TJ, Luo J, Woodcock EA. Filtz TM, et al. Among authors: grubb dr. FASEB J. 2009 Oct;23(10):3564-70. doi: 10.1096/fj.09-133983. Epub 2009 Jun 29. FASEB J. 2009. PMID: 19564249

4

Phospholipase Cbeta1b associates with a Shank3 complex at the cardiac sarcolemma.

Grubb DR, Iliades P, Cooley N, Yu YL, Luo J, Filtz TM, Woodcock EA. Grubb DR, et al. FASEB J. 2011 Mar;25(3):1040-7. doi: 10.1096/fj.10-171470. Epub 2010 Dec 9. FASEB J. 2011. PMID: 21148417

5

Scaffolding protein Homer 1c mediates hypertrophic responses downstream of Gq in cardiomyocytes.

Grubb DR, Luo J, Yu YL, Woodcock EA. Grubb DR, et al. FASEB J. 2012 Feb;26(2):596-603. doi: 10.1096/fj.11-190330. Epub 2011 Oct 19. FASEB J. 2012. PMID: 22012123

6

The phosphatidylinositol(4,5)bisphosphate-binding sequence of transient receptor potential channel canonical 4α is critical for its contribution to cardiomyocyte hypertrophy.

Cooley N, Grubb DR, Luo J, Woodcock EA. Cooley N, et al. Among authors: grubb dr. Mol Pharmacol. 2014 Oct;86(4):399-405. doi: 10.1124/mol.114.093690. Epub 2014 Jul 21. Mol Pharmacol. 2014. PMID: 25049082

7

Phospholipase Cβ1b directly binds the SH3 domain of Shank3 for targeting and activation in cardiomyocytes.

Grubb DR, Luo J, Woodcock EA. Grubb DR, et al. Biochem Biophys Res Commun. 2015 Jun 5;461(3):519-24. doi: 10.1016/j.bbrc.2015.04.060. Epub 2015 Apr 21. Biochem Biophys Res Commun. 2015. PMID: 25911318

8

Ins(1,4,5)P(3) regulates phospholipase Cbeta1 expression in cardiomyocytes.

Vasilevski O, Grubb DR, Filtz TM, Yang S, McLeod-Dryden TJ, Luo J, Karna D, Chen J, Woodcock EA. Vasilevski O, et al. Among authors: grubb dr. J Mol Cell Cardiol. 2008 Nov;45(5):679-84. doi: 10.1016/j.yjmcc.2008.07.006. Epub 2008 Jul 23. J Mol Cell Cardiol. 2008. PMID: 18692062

9

Selective activation of the "b" splice variant of phospholipase Cbeta1 in chronically dilated human and mouse atria.

Woodcock EA, Grubb DR, Filtz TM, Marasco S, Luo J, McLeod-Dryden TJ, Kaye DM, Sadoshima J, Du XJ, Wong C, McMullen JR, Dart AM. Woodcock EA, et al. Among authors: grubb dr. J Mol Cell Cardiol. 2009 Nov;47(5):676-83. doi: 10.1016/j.yjmcc.2009.08.020. Epub 2009 Aug 31. J Mol Cell Cardiol. 2009. PMID: 19729020

10

Regulation of autophagy in cardiomyocytes by Ins(1,4,5)P(3) and IP(3)-receptors.

Wong A, Grubb DR, Cooley N, Luo J, Woodcock EA. Wong A, et al. Among authors: grubb dr. J Mol Cell Cardiol. 2013 Jan;54:19-24. doi: 10.1016/j.yjmcc.2012.10.014. Epub 2012 Nov 5. J Mol Cell Cardiol. 2013. PMID: 23137780

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