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Page 1
CNS leptin action modulates immune response and survival in sepsis.
Tschöp J, Nogueiras R, Haas-Lockie S, Kasten KR, Castañeda TR, Huber N, Guanciale K, Perez-Tilve D, Habegger K, Ottaway N, Woods SC, Oldfield B, Clarke I, Chua S Jr, Farooqi IS, O'Rahilly S, Caldwell CC, Tschöp MH. Tschöp J, et al. Among authors: ottaway n. J Neurosci. 2010 Apr 28;30(17):6036-47. doi: 10.1523/JNEUROSCI.4875-09.2010. J Neurosci. 2010. PMID: 20427662 Free PMC article.
The orphan receptor Gpr83 regulates systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms.
Müller TD, Müller A, Yi CX, Habegger KM, Meyer CW, Gaylinn BD, Finan B, Heppner K, Trivedi C, Bielohuby M, Abplanalp W, Meyer F, Piechowski CL, Pratzka J, Stemmer K, Holland J, Hembree J, Bhardwaj N, Raver C, Ottaway N, Krishna R, Sah R, Sallee FR, Woods SC, Perez-Tilve D, Bidlingmaier M, Thorner MO, Krude H, Smiley D, DiMarchi R, Hofmann S, Pfluger PT, Kleinau G, Biebermann H, Tschöp MH. Müller TD, et al. Among authors: ottaway n. Nat Commun. 2013;4:1968. doi: 10.1038/ncomms2968. Nat Commun. 2013. PMID: 23744028 Free PMC article.
Restoration of leptin responsiveness in diet-induced obese mice using an optimized leptin analog in combination with exendin-4 or FGF21.
Müller TD, Sullivan LM, Habegger K, Yi CX, Kabra D, Grant E, Ottaway N, Krishna R, Holland J, Hembree J, Perez-Tilve D, Pfluger PT, DeGuzman MJ, Siladi ME, Kraynov VS, Axelrod DW, DiMarchi R, Pinkstaff JK, Tschöp MH. Müller TD, et al. Among authors: ottaway n. J Pept Sci. 2012 Jun;18(6):383-93. doi: 10.1002/psc.2408. Epub 2012 May 4. J Pept Sci. 2012. PMID: 22565812
Hormones and diet, but not body weight, control hypothalamic microglial activity.
Gao Y, Ottaway N, Schriever SC, Legutko B, García-Cáceres C, de la Fuente E, Mergen C, Bour S, Thaler JP, Seeley RJ, Filosa J, Stern JE, Perez-Tilve D, Schwartz MW, Tschöp MH, Yi CX. Gao Y, et al. Among authors: ottaway n. Glia. 2014 Jan;62(1):17-25. doi: 10.1002/glia.22580. Epub 2013 Oct 28. Glia. 2014. PMID: 24166765 Free PMC article.
p62 links β-adrenergic input to mitochondrial function and thermogenesis.
Müller TD, Lee SJ, Jastroch M, Kabra D, Stemmer K, Aichler M, Abplanalp B, Ananthakrishnan G, Bhardwaj N, Collins S, Divanovic S, Endele M, Finan B, Gao Y, Habegger KM, Hembree J, Heppner KM, Hofmann S, Holland J, Küchler D, Kutschke M, Krishna R, Lehti M, Oelkrug R, Ottaway N, Perez-Tilve D, Raver C, Walch AK, Schriever SC, Speakman J, Tseng YH, Diaz-Meco M, Pfluger PT, Moscat J, Tschöp MH. Müller TD, et al. Among authors: ottaway n. J Clin Invest. 2013 Jan;123(1):469-78. doi: 10.1172/JCI64209. Epub 2012 Dec 21. J Clin Invest. 2013. PMID: 23257354 Free PMC article.
The GOAT-ghrelin system is not essential for hypoglycemia prevention during prolonged calorie restriction.
Yi CX, Heppner KM, Kirchner H, Tong J, Bielohuby M, Gaylinn BD, Müller TD, Bartley E, Davis HW, Zhao Y, Joseph A, Kruthaupt T, Ottaway N, Kabra D, Habegger KM, Benoit SC, Bidlingmaier M, Thorner MO, Perez-Tilve D, Tschöp MH, Pfluger PT. Yi CX, et al. Among authors: ottaway n. PLoS One. 2012;7(2):e32100. doi: 10.1371/journal.pone.0032100. Epub 2012 Feb 21. PLoS One. 2012. PMID: 22363801 Free PMC article.
Caloric restriction chronically impairs metabolic programming in mice.
Kirchner H, Hofmann SM, Fischer-Rosinský A, Hembree J, Abplanalp W, Ottaway N, Donelan E, Krishna R, Woods SC, Müller TD, Spranger J, Perez-Tilve D, Pfluger PT, Tschöp MH, Habegger KM. Kirchner H, et al. Among authors: ottaway n. Diabetes. 2012 Nov;61(11):2734-42. doi: 10.2337/db11-1621. Epub 2012 Jul 10. Diabetes. 2012. PMID: 22787140 Free PMC article.
Acylation type determines ghrelin's effects on energy homeostasis in rodents.
Heppner KM, Chaudhary N, Müller TD, Kirchner H, Habegger KM, Ottaway N, Smiley DL, Dimarchi R, Hofmann SM, Woods SC, Sivertsen B, Holst B, Pfluger PT, Perez-Tilve D, Tschöp MH. Heppner KM, et al. Among authors: ottaway n. Endocrinology. 2012 Oct;153(10):4687-95. doi: 10.1210/en.2012-1194. Epub 2012 Aug 3. Endocrinology. 2012. PMID: 22865372 Free PMC article.
Targeted estrogen delivery reverses the metabolic syndrome.
Finan B, Yang B, Ottaway N, Stemmer K, Müller TD, Yi CX, Habegger K, Schriever SC, García-Cáceres C, Kabra DG, Hembree J, Holland J, Raver C, Seeley RJ, Hans W, Irmler M, Beckers J, de Angelis MH, Tiano JP, Mauvais-Jarvis F, Perez-Tilve D, Pfluger P, Zhang L, Gelfanov V, DiMarchi RD, Tschöp MH. Finan B, et al. Among authors: ottaway n. Nat Med. 2012 Dec;18(12):1847-56. doi: 10.1038/nm.3009. Epub 2012 Nov 11. Nat Med. 2012. PMID: 23142820 Free PMC article.
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