Gelb MH - Search Results

1

Second generation analogues of the cancer drug clinical candidate tipifarnib for anti-Chagas disease drug discovery.

Kraus JM, Tatipaka HB, McGuffin SA, Chennamaneni NK, Karimi M, Arif J, Verlinde CL, Buckner FS, Gelb MH. Kraus JM, et al. Among authors: gelb mh. J Med Chem. 2010 May 27;53(10):3887-98. doi: 10.1021/jm9013136. J Med Chem. 2010. PMID: 20429511 Free PMC article.

2

Protein prenylation: from discovery to prospects for cancer treatment.

Gelb MH, Scholten JD, Sebolt-Leopold JS. Gelb MH, et al. Curr Opin Chem Biol. 1998 Feb;2(1):40-8. doi: 10.1016/s1367-5931(98)80034-3. Curr Opin Chem Biol. 1998. PMID: 9667914 Review.

3

The effects of protein farnesyltransferase inhibitors on trypanosomatids: inhibition of protein farnesylation and cell growth.

Yokoyama K, Trobridge P, Buckner FS, Scholten J, Stuart KD, Van Voorhis WC, Gelb MH. Yokoyama K, et al. Among authors: gelb mh. Mol Biochem Parasitol. 1998 Jul 1;94(1):87-97. doi: 10.1016/s0166-6851(98)00053-x. Mol Biochem Parasitol. 1998. PMID: 9719512

4

Protein farnesyltransferase from Trypanosoma brucei. A heterodimer of 61- and 65-kda subunits as a new target for antiparasite therapeutics.

Yokoyama K, Trobridge P, Buckner FS, Van Voorhis WC, Stuart KD, Gelb MH. Yokoyama K, et al. Among authors: gelb mh. J Biol Chem. 1998 Oct 9;273(41):26497-505. doi: 10.1074/jbc.273.41.26497. J Biol Chem. 1998. PMID: 9756885 Free article.

5

Selective tight binding inhibitors of trypanosomal glyceraldehyde-3-phosphate dehydrogenase via structure-based drug design.

Aronov AM, Verlinde CL, Hol WG, Gelb MH. Aronov AM, et al. Among authors: gelb mh. J Med Chem. 1998 Nov 19;41(24):4790-9. doi: 10.1021/jm9802620. J Med Chem. 1998. PMID: 9822549

6

Synthesis and structure-activity relationships of adenosine analogs as inhibitors of trypanosomal glyceraldehyde-3-phosphate dehydrogenase. Modifications at positions 5' and 8.

Aronov AM, Gelb MH. Aronov AM, et al. Among authors: gelb mh. Bioorg Med Chem Lett. 1998 Dec 15;8(24):3505-10. doi: 10.1016/s0960-894x(98)00635-0. Bioorg Med Chem Lett. 1998. PMID: 9934461

7

Structure-based design of submicromolar, biologically active inhibitors of trypanosomatid glyceraldehyde-3-phosphate dehydrogenase.

Aronov AM, Suresh S, Buckner FS, Van Voorhis WC, Verlinde CL, Opperdoes FR, Hol WG, Gelb MH. Aronov AM, et al. Among authors: gelb mh. Proc Natl Acad Sci U S A. 1999 Apr 13;96(8):4273-8. doi: 10.1073/pnas.96.8.4273. Proc Natl Acad Sci U S A. 1999. PMID: 10200252 Free PMC article.

8

1,3-Dioxane-4,6-dione-5-carboxamide-based inhibitors of human group IIA phospholipase A: X-ray structure of the complex and interfacial selection of inhibitors from a structural library.

Bryant MD, Flick KE, Koduri RS, Wilton DC, Stoddard BL, Gelb MH. Bryant MD, et al. Among authors: gelb mh. Bioorg Med Chem Lett. 1999 Apr 19;9(8):1097-102. doi: 10.1016/s0960-894x(99)00147-x. Bioorg Med Chem Lett. 1999. PMID: 10328292

9

Cloning, heterologous expression, and distinct substrate specificity of protein farnesyltransferase from Trypanosoma brucei.

Buckner FS, Yokoyama K, Nguyen L, Grewal A, Erdjument-Bromage H, Tempst P, Strickland CL, Xiao L, Van Voorhis WC, Gelb MH. Buckner FS, et al. Among authors: gelb mh. J Biol Chem. 2000 Jul 21;275(29):21870-6. doi: 10.1074/jbc.M000975200. J Biol Chem. 2000. PMID: 10749864 Free PMC article.

10

Adenosine analogues as inhibitors of Trypanosoma brucei phosphoglycerate kinase: elucidation of a novel binding mode for a 2-amino-N(6)-substituted adenosine.

Bressi JC, Choe J, Hough MT, Buckner FS, Van Voorhis WC, Verlinde CL, Hol WG, Gelb MH. Bressi JC, et al. Among authors: gelb mh. J Med Chem. 2000 Nov 2;43(22):4135-50. doi: 10.1021/jm000287a. J Med Chem. 2000. PMID: 11063610

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