Barak LS - Search Results

1

Identification of select glucocorticoids as Smoothened agonists: potential utility for regenerative medicine.

Wang J, Lu J, Bond MC, Chen M, Ren XR, Lyerly HK, Barak LS, Chen W. Wang J, et al. Among authors: barak ls. Proc Natl Acad Sci U S A. 2010 May 18;107(20):9323-8. doi: 10.1073/pnas.0910712107. Epub 2010 May 3. Proc Natl Acad Sci U S A. 2010. PMID: 20439738 Free PMC article.

2

Role for G protein-coupled receptor kinase in agonist-specific regulation of mu-opioid receptor responsiveness.

Zhang J, Ferguson SS, Barak LS, Bodduluri SR, Laporte SA, Law PY, Caron MG. Zhang J, et al. Among authors: barak ls. Proc Natl Acad Sci U S A. 1998 Jun 9;95(12):7157-62. doi: 10.1073/pnas.95.12.7157. Proc Natl Acad Sci U S A. 1998. PMID: 9618555 Free PMC article.

3

The beta2-adrenergic receptor/betaarrestin complex recruits the clathrin adaptor AP-2 during endocytosis.

Laporte SA, Oakley RH, Zhang J, Holt JA, Ferguson SS, Caron MG, Barak LS. Laporte SA, et al. Among authors: barak ls. Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):3712-7. doi: 10.1073/pnas.96.7.3712. Proc Natl Acad Sci U S A. 1999. PMID: 10097102 Free PMC article.

4

Constitutive arrestin-mediated desensitization of a human vasopressin receptor mutant associated with nephrogenic diabetes insipidus.

Barak LS, Oakley RH, Laporte SA, Caron MG. Barak LS, et al. Proc Natl Acad Sci U S A. 2001 Jan 2;98(1):93-8. doi: 10.1073/pnas.98.1.93. Proc Natl Acad Sci U S A. 2001. PMID: 11134505 Free PMC article.

5

Dishevelled 2 recruits beta-arrestin 2 to mediate Wnt5A-stimulated endocytosis of Frizzled 4.

Chen W, ten Berge D, Brown J, Ahn S, Hu LA, Miller WE, Caron MG, Barak LS, Nusse R, Lefkowitz RJ. Chen W, et al. Among authors: barak ls. Science. 2003 Sep 5;301(5638):1391-4. doi: 10.1126/science.1082808. Science. 2003. PMID: 12958364

6

Activity-dependent internalization of smoothened mediated by beta-arrestin 2 and GRK2.

Chen W, Ren XR, Nelson CD, Barak LS, Chen JK, Beachy PA, de Sauvage F, Lefkowitz RJ. Chen W, et al. Among authors: barak ls. Science. 2004 Dec 24;306(5705):2257-60. doi: 10.1126/science.1104135. Science. 2004. PMID: 15618519

7

Smoothened signaling in vertebrates is facilitated by a G protein-coupled receptor kinase.

Philipp M, Fralish GB, Meloni AR, Chen W, MacInnes AW, Barak LS, Caron MG. Philipp M, et al. Among authors: barak ls. Mol Biol Cell. 2008 Dec;19(12):5478-89. doi: 10.1091/mbc.e08-05-0448. Epub 2008 Sep 24. Mol Biol Cell. 2008. PMID: 18815277 Free PMC article.

8

The anti-helminthic niclosamide inhibits Wnt/Frizzled1 signaling.

Chen M, Wang J, Lu J, Bond MC, Ren XR, Lyerly HK, Barak LS, Chen W. Chen M, et al. Among authors: barak ls. Biochemistry. 2009 Nov 3;48(43):10267-74. doi: 10.1021/bi9009677. Biochemistry. 2009. PMID: 19772353 Free PMC article.

9

Development of small molecules targeting the Wnt pathway for the treatment of colon cancer: a high-throughput screening approach.

Chen W, Chen M, Barak LS. Chen W, et al. Among authors: barak ls. Am J Physiol Gastrointest Liver Physiol. 2010 Aug;299(2):G293-300. doi: 10.1152/ajpgi.00005.2010. Epub 2010 May 27. Am J Physiol Gastrointest Liver Physiol. 2010. PMID: 20508156 Free PMC article. Review.

10

Targeting of the orphan receptor GPR35 by pamoic acid: a potent activator of extracellular signal-regulated kinase and β-arrestin2 with antinociceptive activity.

Zhao P, Sharir H, Kapur A, Cowan A, Geller EB, Adler MW, Seltzman HH, Reggio PH, Heynen-Genel S, Sauer M, Chung TD, Bai Y, Chen W, Caron MG, Barak LS, Abood ME. Zhao P, et al. Among authors: barak ls. Mol Pharmacol. 2010 Oct;78(4):560-8. doi: 10.1124/mol.110.066746. Epub 2010 Jul 22. Mol Pharmacol. 2010. PMID: 20826425 Free PMC article.

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