Sabatini DM - Search Results

1

Rictor phosphorylation on the Thr-1135 site does not require mammalian target of rapamycin complex 2.

Boulbes D, Chen CH, Shaikenov T, Agarwal NK, Peterson TR, Addona TA, Keshishian H, Carr SA, Magnuson MA, Sabatini DM, Sarbassov dos D. Boulbes D, et al. Among authors: sabatini dm. Mol Cancer Res. 2010 Jun;8(6):896-906. doi: 10.1158/1541-7786.MCR-09-0409. Epub 2010 May 25. Mol Cancer Res. 2010. PMID: 20501647 Free PMC article.

2

Rapamycin derivatives reduce mTORC2 signaling and inhibit AKT activation in AML.

Zeng Z, Sarbassov dos D, Samudio IJ, Yee KW, Munsell MF, Ellen Jackson C, Giles FJ, Sabatini DM, Andreeff M, Konopleva M. Zeng Z, et al. Among authors: sabatini dm. Blood. 2007 Apr 15;109(8):3509-12. doi: 10.1182/blood-2006-06-030833. Epub 2006 Dec 19. Blood. 2007. PMID: 17179228 Free PMC article.

3

Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress.

Sengupta S, Peterson TR, Sabatini DM. Sengupta S, et al. Among authors: sabatini dm. Mol Cell. 2010 Oct 22;40(2):310-22. doi: 10.1016/j.molcel.2010.09.026. Mol Cell. 2010. PMID: 20965424 Free PMC article. Review.

4

PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase.

Sancak Y, Thoreen CC, Peterson TR, Lindquist RA, Kang SA, Spooner E, Carr SA, Sabatini DM. Sancak Y, et al. Among authors: sabatini dm. Mol Cell. 2007 Mar 23;25(6):903-15. doi: 10.1016/j.molcel.2007.03.003. Mol Cell. 2007. PMID: 17386266 Free article.

5

mTOR complex 2 is required for the development of prostate cancer induced by Pten loss in mice.

Guertin DA, Stevens DM, Saitoh M, Kinkel S, Crosby K, Sheen JH, Mullholland DJ, Magnuson MA, Wu H, Sabatini DM. Guertin DA, et al. Among authors: sabatini dm. Cancer Cell. 2009 Feb 3;15(2):148-59. doi: 10.1016/j.ccr.2008.12.017. Cancer Cell. 2009. PMID: 19185849 Free PMC article.

6

mTORC1 controls fasting-induced ketogenesis and its modulation by ageing.

Sengupta S, Peterson TR, Laplante M, Oh S, Sabatini DM. Sengupta S, et al. Among authors: sabatini dm. Nature. 2010 Dec 23;468(7327):1100-4. doi: 10.1038/nature09584. Nature. 2010. PMID: 21179166

7

mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s.

Frias MA, Thoreen CC, Jaffe JD, Schroder W, Sculley T, Carr SA, Sabatini DM. Frias MA, et al. Among authors: sabatini dm. Curr Biol. 2006 Sep 19;16(18):1865-70. doi: 10.1016/j.cub.2006.08.001. Epub 2006 Aug 17. Curr Biol. 2006. PMID: 16919458 Free article.

8

DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival.

Peterson TR, Laplante M, Thoreen CC, Sancak Y, Kang SA, Kuehl WM, Gray NS, Sabatini DM. Peterson TR, et al. Among authors: sabatini dm. Cell. 2009 May 29;137(5):873-86. doi: 10.1016/j.cell.2009.03.046. Epub 2009 May 14. Cell. 2009. PMID: 19446321 Free PMC article.

9

mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway.

Peterson TR, Sengupta SS, Harris TE, Carmack AE, Kang SA, Balderas E, Guertin DA, Madden KL, Carpenter AE, Finck BN, Sabatini DM. Peterson TR, et al. Among authors: sabatini dm. Cell. 2011 Aug 5;146(3):408-20. doi: 10.1016/j.cell.2011.06.034. Cell. 2011. PMID: 21816276 Free PMC article.

10

The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling.

Hsu PP, Kang SA, Rameseder J, Zhang Y, Ottina KA, Lim D, Peterson TR, Choi Y, Gray NS, Yaffe MB, Marto JA, Sabatini DM. Hsu PP, et al. Among authors: sabatini dm. Science. 2011 Jun 10;332(6035):1317-22. doi: 10.1126/science.1199498. Science. 2011. PMID: 21659604 Free PMC article.

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