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Nifedipine induces peroxisome proliferator-activated receptor-gamma activation in macrophages and suppresses the progression of atherosclerosis in apolipoprotein E-deficient mice.
Ishii N, Matsumura T, Kinoshita H, Fukuda K, Motoshima H, Senokuchi T, Nakao S, Tsutsumi A, Kim-Mitsuyama S, Kawada T, Takeya M, Miyamura N, Nishikawa T, Araki E. Ishii N, et al. Arterioscler Thromb Vasc Biol. 2010 Aug;30(8):1598-605. doi: 10.1161/ATVBAHA.109.202309. Epub 2010 May 27. Arterioscler Thromb Vasc Biol. 2010. PMID: 20508203
Important role of apoptosis signal-regulating kinase 1 in ischemia-induced angiogenesis.
Izumi Y, Kim-Mitsuyama S, Yoshiyama M, Omura T, Shiota M, Matsuzawa A, Yukimura T, Murohara T, Takeya M, Ichijo H, Yoshikawa J, Iwao H. Izumi Y, et al. Arterioscler Thromb Vasc Biol. 2005 Sep;25(9):1877-83. doi: 10.1161/01.ATV.0000174801.76234.bd. Epub 2005 Jun 23. Arterioscler Thromb Vasc Biol. 2005. PMID: 15976330
Oxidized low density lipoprotein activates peroxisome proliferator-activated receptor-alpha (PPARalpha) and PPARgamma through MAPK-dependent COX-2 expression in macrophages.
Taketa K, Matsumura T, Yano M, Ishii N, Senokuchi T, Motoshima H, Murata Y, Kim-Mitsuyama S, Kawada T, Itabe H, Takeya M, Nishikawa T, Tsuruzoe K, Araki E. Taketa K, et al. J Biol Chem. 2008 Apr 11;283(15):9852-62. doi: 10.1074/jbc.M703318200. Epub 2008 Jan 21. J Biol Chem. 2008. PMID: 18208815 Free article.
Telmisartan protects against diabetic vascular complications in a mouse model of obesity and type 2 diabetes, partially through peroxisome proliferator activated receptor-γ-dependent activity.
Toyama K, Nakamura T, Kataoka K, Yasuda O, Fukuda M, Tokutomi Y, Dong YF, Ogawa H, Kim-Mitsuyama S. Toyama K, et al. Biochem Biophys Res Commun. 2011 Jul 8;410(3):508-13. doi: 10.1016/j.bbrc.2011.06.012. Epub 2011 Jun 7. Biochem Biophys Res Commun. 2011. PMID: 21679694
Passive exercise using whole-body periodic acceleration enhances blood supply to ischemic hindlimb.
Rokutanda T, Izumiya Y, Miura M, Fukuda S, Shimada K, Izumi Y, Nakamura Y, Araki S, Hanatani S, Matsubara J, Nakamura T, Kataoka K, Yasuda O, Kaikita K, Sugiyama S, Kim-Mitsuyama S, Yoshikawa J, Fujita M, Yoshiyama M, Ogawa H. Rokutanda T, et al. Arterioscler Thromb Vasc Biol. 2011 Dec;31(12):2872-80. doi: 10.1161/ATVBAHA.111.229773. Epub 2011 Sep 22. Arterioscler Thromb Vasc Biol. 2011. PMID: 21940947 Clinical Trial.
A dipeptidyl peptidase-4 inhibitor, des-fluoro-sitagliptin, improves endothelial function and reduces atherosclerotic lesion formation in apolipoprotein E-deficient mice.
Matsubara J, Sugiyama S, Sugamura K, Nakamura T, Fujiwara Y, Akiyama E, Kurokawa H, Nozaki T, Ohba K, Konishi M, Maeda H, Izumiya Y, Kaikita K, Sumida H, Jinnouchi H, Matsui K, Kim-Mitsuyama S, Takeya M, Ogawa H. Matsubara J, et al. J Am Coll Cardiol. 2012 Jan 17;59(3):265-76. doi: 10.1016/j.jacc.2011.07.053. J Am Coll Cardiol. 2012. PMID: 22240132 Free article.
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