Yan H - Search Results

1

Isocitrate dehydrogenase 1 and 2 mutations in cancer: alterations at a crossroads of cellular metabolism.

Reitman ZJ, Yan H. Reitman ZJ, et al. Among authors: yan h. J Natl Cancer Inst. 2010 Jul 7;102(13):932-41. doi: 10.1093/jnci/djq187. Epub 2010 May 31. J Natl Cancer Inst. 2010. PMID: 20513808 Free PMC article. Review.

2

IDH1 and IDH2: not your typical oncogenes.

Reitman ZJ, Parsons DW, Yan H. Reitman ZJ, et al. Among authors: yan h. Cancer Cell. 2010 Mar 16;17(3):215-6. doi: 10.1016/j.ccr.2010.02.024. Cancer Cell. 2010. PMID: 20227034 Free PMC article.

3

IDH1(R132) mutation identified in one human melanoma metastasis, but not correlated with metastases to the brain.

Lopez GY, Reitman ZJ, Solomon D, Waldman T, Bigner DD, McLendon RE, Rosenberg SA, Samuels Y, Yan H. Lopez GY, et al. Among authors: yan h. Biochem Biophys Res Commun. 2010 Jul 30;398(3):585-7. doi: 10.1016/j.bbrc.2010.06.125. Epub 2010 Jul 13. Biochem Biophys Res Commun. 2010. PMID: 20603105 Free PMC article.

4

Profiling the effects of isocitrate dehydrogenase 1 and 2 mutations on the cellular metabolome.

Reitman ZJ, Jin G, Karoly ED, Spasojevic I, Yang J, Kinzler KW, He Y, Bigner DD, Vogelstein B, Yan H. Reitman ZJ, et al. Among authors: yan h. Proc Natl Acad Sci U S A. 2011 Feb 22;108(8):3270-5. doi: 10.1073/pnas.1019393108. Epub 2011 Feb 2. Proc Natl Acad Sci U S A. 2011. PMID: 21289278 Free PMC article.

5

2-hydroxyglutarate production, but not dominant negative function, is conferred by glioma-derived NADP-dependent isocitrate dehydrogenase mutations.

Jin G, Reitman ZJ, Spasojevic I, Batinic-Haberle I, Yang J, Schmidt-Kittler O, Bigner DD, Yan H. Jin G, et al. Among authors: yan h. PLoS One. 2011 Feb 4;6(2):e16812. doi: 10.1371/journal.pone.0016812. PLoS One. 2011. PMID: 21326614 Free PMC article.

6

Enzyme redesign guided by cancer-derived IDH1 mutations.

Reitman ZJ, Choi BD, Spasojevic I, Bigner DD, Sampson JH, Yan H. Reitman ZJ, et al. Among authors: yan h. Nat Chem Biol. 2012 Nov;8(11):887-9. doi: 10.1038/nchembio.1065. Epub 2012 Sep 23. Nat Chem Biol. 2012. PMID: 23001033 Free PMC article.

7

Disruption of wild-type IDH1 suppresses D-2-hydroxyglutarate production in IDH1-mutated gliomas.

Jin G, Reitman ZJ, Duncan CG, Spasojevic I, Gooden DM, Rasheed BA, Yang R, Lopez GY, He Y, McLendon RE, Bigner DD, Yan H. Jin G, et al. Among authors: yan h. Cancer Res. 2013 Jan 15;73(2):496-501. doi: 10.1158/0008-5472.CAN-12-2852. Epub 2012 Nov 30. Cancer Res. 2013. PMID: 23204232 Free PMC article.

8

Releasing the block: setting differentiation free with mutant IDH inhibitors.

Pirozzi CJ, Reitman ZJ, Yan H. Pirozzi CJ, et al. Among authors: yan h. Cancer Cell. 2013 May 13;23(5):570-2. doi: 10.1016/j.ccr.2013.04.024. Cancer Cell. 2013. PMID: 23680144 Free PMC article.

9

Cancer-associated isocitrate dehydrogenase 1 (IDH1) R132H mutation and d-2-hydroxyglutarate stimulate glutamine metabolism under hypoxia.

Reitman ZJ, Duncan CG, Poteet E, Winters A, Yan LJ, Gooden DM, Spasojevic I, Boros LG, Yang SH, Yan H. Reitman ZJ, et al. Among authors: yan h, yan lj. J Biol Chem. 2014 Aug 22;289(34):23318-28. doi: 10.1074/jbc.M114.575183. Epub 2014 Jul 1. J Biol Chem. 2014. PMID: 24986863 Free PMC article.

10

Genetic dissection of leukemia-associated IDH1 and IDH2 mutants and D-2-hydroxyglutarate in Drosophila.

Reitman ZJ, Sinenko SA, Spana EP, Yan H. Reitman ZJ, et al. Among authors: yan h. Blood. 2015 Jan 8;125(2):336-45. doi: 10.1182/blood-2014-05-577940. Epub 2014 Nov 14. Blood. 2015. PMID: 25398939 Free PMC article.

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