Charlton P - Search Results

1

Impact of pan-caspase inhibition in animal models of established steatosis and non-alcoholic steatohepatitis.

Anstee QM, Concas D, Kudo H, Levene A, Pollard J, Charlton P, Thomas HC, Thursz MR, Goldin RD. Anstee QM, et al. Among authors: charlton p. J Hepatol. 2010 Sep;53(3):542-50. doi: 10.1016/j.jhep.2010.03.016. Epub 2010 May 26. J Hepatol. 2010. PMID: 20557969

2

Pan-caspase inhibitor VX-166 reduces fibrosis in an animal model of nonalcoholic steatohepatitis.

Witek RP, Stone WC, Karaca FG, Syn WK, Pereira TA, Agboola KM, Omenetti A, Jung Y, Teaberry V, Choi SS, Guy CD, Pollard J, Charlton P, Diehl AM. Witek RP, et al. Among authors: charlton p. Hepatology. 2009 Nov;50(5):1421-30. doi: 10.1002/hep.23167. Hepatology. 2009. PMID: 19676126

3

Kinetic and mechanistic characterisation of Choline Kinase-α.

Hudson CS, Knegtel RM, Brown K, Charlton PA, Pollard JR. Hudson CS, et al. Biochim Biophys Acta. 2013 Jun;1834(6):1107-16. doi: 10.1016/j.bbapap.2013.02.008. Epub 2013 Feb 13. Biochim Biophys Acta. 2013. PMID: 23416529

4

The novel ATR inhibitor VE-821 increases sensitivity of pancreatic cancer cells to radiation and chemotherapy.

Prevo R, Fokas E, Reaper PM, Charlton PA, Pollard JR, McKenna WG, Muschel RJ, Brunner TB. Prevo R, et al. Cancer Biol Ther. 2012 Sep;13(11):1072-81. doi: 10.4161/cbt.21093. Epub 2012 Jul 24. Cancer Biol Ther. 2012. PMID: 22825331 Free PMC article.

5

Selective killing of ATM- or p53-deficient cancer cells through inhibition of ATR.

Reaper PM, Griffiths MR, Long JM, Charrier JD, Maccormick S, Charlton PA, Golec JM, Pollard JR. Reaper PM, et al. Nat Chem Biol. 2011 Apr 13;7(7):428-30. doi: 10.1038/nchembio.573. Nat Chem Biol. 2011. PMID: 21490603

6

Structural basis for potent inhibition of the Aurora kinases and a T315I multi-drug resistant mutant form of Abl kinase by VX-680.

Cheetham GM, Charlton PA, Golec JM, Pollard JR. Cheetham GM, et al. Among authors: charlton pa. Cancer Lett. 2007 Jun 28;251(2):323-9. doi: 10.1016/j.canlet.2006.12.004. Epub 2007 Jan 19. Cancer Lett. 2007. PMID: 17240048

7

Targeting radiation-resistant hypoxic tumour cells through ATR inhibition.

Pires IM, Olcina MM, Anbalagan S, Pollard JR, Reaper PM, Charlton PA, McKenna WG, Hammond EM. Pires IM, et al. Among authors: charlton pa. Br J Cancer. 2012 Jul 10;107(2):291-9. doi: 10.1038/bjc.2012.265. Epub 2012 Jun 19. Br J Cancer. 2012. PMID: 22713662 Free PMC article.

8

Targeting ATR in vivo using the novel inhibitor VE-822 results in selective sensitization of pancreatic tumors to radiation.

Fokas E, Prevo R, Pollard JR, Reaper PM, Charlton PA, Cornelissen B, Vallis KA, Hammond EM, Olcina MM, Gillies McKenna W, Muschel RJ, Brunner TB. Fokas E, et al. Among authors: charlton pa. Cell Death Dis. 2012 Dec 6;3(12):e441. doi: 10.1038/cddis.2012.181. Cell Death Dis. 2012. PMID: 23222511 Free PMC article.

9

Cancer-Specific Synthetic Lethality between ATR and CHK1 Kinase Activities.

Sanjiv K, Hagenkort A, Calderón-Montaño JM, Koolmeister T, Reaper PM, Mortusewicz O, Jacques SA, Kuiper RV, Schultz N, Scobie M, Charlton PA, Pollard JR, Berglund UW, Altun M, Helleday T. Sanjiv K, et al. Cell Rep. 2016 Jan 12;14(2):298-309. doi: 10.1016/j.celrep.2015.12.032. Epub 2015 Dec 31. Cell Rep. 2016. PMID: 26748709 Free PMC article.

10

Structure of human Bloom's syndrome helicase in complex with ADP and duplex DNA.

Swan MK, Legris V, Tanner A, Reaper PM, Vial S, Bordas R, Pollard JR, Charlton PA, Golec JM, Bertrand JA. Swan MK, et al. Acta Crystallogr D Biol Crystallogr. 2014 May;70(Pt 5):1465-75. doi: 10.1107/S139900471400501X. Epub 2014 Apr 30. Acta Crystallogr D Biol Crystallogr. 2014. PMID: 24816114

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