O'Kane CJ - Search Results

1

Antioxidants can inhibit basal autophagy and enhance neurodegeneration in models of polyglutamine disease.

Underwood BR, Imarisio S, Fleming A, Rose C, Krishna G, Heard P, Quick M, Korolchuk VI, Renna M, Sarkar S, García-Arencibia M, O'Kane CJ, Murphy MP, Rubinsztein DC. Underwood BR, et al. Hum Mol Genet. 2010 Sep 1;19(17):3413-29. doi: 10.1093/hmg/ddq253. Epub 2010 Jun 21. Hum Mol Genet. 2010. PMID: 20566712 Free PMC article.

2

Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease.

Ravikumar B, Vacher C, Berger Z, Davies JE, Luo S, Oroz LG, Scaravilli F, Easton DF, Duden R, O'Kane CJ, Rubinsztein DC. Ravikumar B, et al. Nat Genet. 2004 Jun;36(6):585-95. doi: 10.1038/ng1362. Epub 2004 May 16. Nat Genet. 2004. PMID: 15146184

3

Dynein mutations impair autophagic clearance of aggregate-prone proteins.

Ravikumar B, Acevedo-Arozena A, Imarisio S, Berger Z, Vacher C, O'Kane CJ, Brown SD, Rubinsztein DC. Ravikumar B, et al. Nat Genet. 2005 Jul;37(7):771-6. doi: 10.1038/ng1591. Epub 2005 Jun 26. Nat Genet. 2005. PMID: 15980862

4

Lithium rescues toxicity of aggregate-prone proteins in Drosophila by perturbing Wnt pathway.

Berger Z, Ttofi EK, Michel CH, Pasco MY, Tenant S, Rubinsztein DC, O'Kane CJ. Berger Z, et al. Hum Mol Genet. 2005 Oct 15;14(20):3003-11. doi: 10.1093/hmg/ddi331. Epub 2005 Sep 2. Hum Mol Genet. 2005. PMID: 16141285

5

Rapamycin alleviates toxicity of different aggregate-prone proteins.

Berger Z, Ravikumar B, Menzies FM, Oroz LG, Underwood BR, Pangalos MN, Schmitt I, Wullner U, Evert BO, O'Kane CJ, Rubinsztein DC. Berger Z, et al. Hum Mol Genet. 2006 Feb 1;15(3):433-42. doi: 10.1093/hmg/ddi458. Epub 2005 Dec 20. Hum Mol Genet. 2006. PMID: 16368705

6

Deleterious and protective properties of an aggregate-prone protein with a polyalanine expansion.

Berger Z, Davies JE, Luo S, Pasco MY, Majoul I, O'Kane CJ, Rubinsztein DC. Berger Z, et al. Hum Mol Genet. 2006 Feb 1;15(3):453-65. doi: 10.1093/hmg/ddi460. Epub 2005 Dec 21. Hum Mol Genet. 2006. PMID: 16371423

7

Rapamycin pre-treatment protects against apoptosis.

Ravikumar B, Berger Z, Vacher C, O'Kane CJ, Rubinsztein DC. Ravikumar B, et al. Hum Mol Genet. 2006 Apr 1;15(7):1209-16. doi: 10.1093/hmg/ddl036. Epub 2006 Feb 23. Hum Mol Genet. 2006. PMID: 16497721

8

Dyneins, autophagy, aggregation and neurodegeneration.

Rubinsztein DC, Ravikumar B, Acevedo-Arozena A, Imarisio S, O'Kane CJ, Brown SD. Rubinsztein DC, et al. Autophagy. 2005 Oct-Dec;1(3):177-8. doi: 10.4161/auto.1.3.2050. Epub 2005 Oct 21. Autophagy. 2005. PMID: 16874055 Review.

9

Small molecules enhance autophagy and reduce toxicity in Huntington's disease models.

Sarkar S, Perlstein EO, Imarisio S, Pineau S, Cordenier A, Maglathlin RL, Webster JA, Lewis TA, O'Kane CJ, Schreiber SL, Rubinsztein DC. Sarkar S, et al. Nat Chem Biol. 2007 Jun;3(6):331-8. doi: 10.1038/nchembio883. Epub 2007 May 7. Nat Chem Biol. 2007. PMID: 17486044 Free PMC article.

10

A rational mechanism for combination treatment of Huntington's disease using lithium and rapamycin.

Sarkar S, Krishna G, Imarisio S, Saiki S, O'Kane CJ, Rubinsztein DC. Sarkar S, et al. Hum Mol Genet. 2008 Jan 15;17(2):170-8. doi: 10.1093/hmg/ddm294. Epub 2007 Oct 6. Hum Mol Genet. 2008. PMID: 17921520

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