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ITH4012 (ethyl 5-amino-6,7,8,9-tetrahydro-2-methyl-4-phenylbenzol[1,8]naphthyridine-3-carboxylate), a novel acetylcholinesterase inhibitor with "calcium promotor" and neuroprotective properties.
Orozco C, de Los Rios C, Arias E, León R, García AG, Marco JL, Villarroya M, López MG. Orozco C, et al. Among authors: leon r. J Pharmacol Exp Ther. 2004 Sep;310(3):987-94. doi: 10.1124/jpet.104.068189. Epub 2004 Apr 26. J Pharmacol Exp Ther. 2004. PMID: 15111641
New multipotent tetracyclic tacrines with neuroprotective activity.
Marco-Contelles J, León R, de los Ríos C, García AG, López MG, Villarroya M. Marco-Contelles J, et al. Among authors: leon r. Bioorg Med Chem. 2006 Dec 15;14(24):8176-85. doi: 10.1016/j.bmc.2006.09.025. Epub 2006 Sep 26. Bioorg Med Chem. 2006. PMID: 17005406
The N-terminal tripeptide of insulin-like growth factor-I protects against beta-amyloid-induced somatostatin depletion by calcium and glycogen synthase kinase 3 beta modulation.
Burgos-Ramos E, Martos-Moreno GA, López MG, Herranz R, Aguado-Llera D, Egea J, Frechilla D, Cenarruzabeitia E, León R, Arilla-Ferreiro E, Argente J, Barrios V. Burgos-Ramos E, et al. Among authors: leon r. J Neurochem. 2009 Apr;109(2):360-70. doi: 10.1111/j.1471-4159.2009.05980.x. Epub 2009 Feb 11. J Neurochem. 2009. PMID: 19220704 Free article.
716 results