Brown ED - Search Results

1

An allosteric inhibitor of substrate recognition by the SCF(Cdc4) ubiquitin ligase.

Orlicky S, Tang X, Neduva V, Elowe N, Brown ED, Sicheri F, Tyers M. Orlicky S, et al. Among authors: brown ed. Nat Biotechnol. 2010 Jul;28(7):733-7. doi: 10.1038/nbt.1646. Epub 2010 Jun 27. Nat Biotechnol. 2010. PMID: 20581844 Free PMC article.

2

High-throughput screening identifies inhibitors of the SARS coronavirus main proteinase.

Blanchard JE, Elowe NH, Huitema C, Fortin PD, Cechetto JD, Eltis LD, Brown ED. Blanchard JE, et al. Among authors: brown ed. Chem Biol. 2004 Oct;11(10):1445-53. doi: 10.1016/j.chembiol.2004.08.011. Chem Biol. 2004. PMID: 15489171 Free PMC article.

3

Experimental screening of dihydrofolate reductase yields a "test set" of 50,000 small molecules for a computational data-mining and docking competition.

Elowe NH, Blanchard JE, Cechetto JD, Brown ED. Elowe NH, et al. Among authors: brown ed. J Biomol Screen. 2005 Oct;10(7):653-7. doi: 10.1177/1087057105281173. Epub 2005 Sep 16. J Biomol Screen. 2005. PMID: 16170050

4

Small-molecule screening made simple for a difficult target with a signaling nucleic acid aptamer that reports on deaminase activity.

Elowe NH, Nutiu R, Allali-Hassani A, Cechetto JD, Hughes DW, Li Y, Brown ED. Elowe NH, et al. Among authors: brown ed. Angew Chem Int Ed Engl. 2006 Aug 25;45(34):5648-52. doi: 10.1002/anie.200601695. Angew Chem Int Ed Engl. 2006. PMID: 16856187 No abstract available.

5

Inhibitors of bacterial cystathionine beta-lyase: leads for new antimicrobial agents and probes of enzyme structure and function.

Ejim LJ, Blanchard JE, Koteva KP, Sumerfield R, Elowe NH, Chechetto JD, Brown ED, Junop MS, Wright GD. Ejim LJ, et al. Among authors: brown ed. J Med Chem. 2007 Feb 22;50(4):755-64. doi: 10.1021/jm061132r. J Med Chem. 2007. PMID: 17300162

6

Combinations of antibiotics and nonantibiotic drugs enhance antimicrobial efficacy.

Ejim L, Farha MA, Falconer SB, Wildenhain J, Coombes BK, Tyers M, Brown ED, Wright GD. Ejim L, et al. Among authors: brown ed. Nat Chem Biol. 2011 Jun;7(6):348-50. doi: 10.1038/nchembio.559. Epub 2011 Apr 24. Nat Chem Biol. 2011. PMID: 21516114

7

Structure of the bacterial teichoic acid polymerase TagF provides insights into membrane association and catalysis.

Lovering AL, Lin LY, Sewell EW, Spreter T, Brown ED, Strynadka NC. Lovering AL, et al. Among authors: brown ed. Nat Struct Mol Biol. 2010 May;17(5):582-9. doi: 10.1038/nsmb.1819. Epub 2010 Apr 18. Nat Struct Mol Biol. 2010. PMID: 20400947

8

Identification of pharmacological chaperones for Gaucher disease and characterization of their effects on beta-glucocerebrosidase by hydrogen/deuterium exchange mass spectrometry.

Tropak MB, Kornhaber GJ, Rigat BA, Maegawa GH, Buttner JD, Blanchard JE, Murphy C, Tuske SJ, Coales SJ, Hamuro Y, Brown ED, Mahuran DJ. Tropak MB, et al. Among authors: brown ed. Chembiochem. 2008 Nov 3;9(16):2650-62. doi: 10.1002/cbic.200800304. Chembiochem. 2008. PMID: 18972510 Free PMC article.

9

Thermodynamic and NMR analysis of inhibitor binding to dihydrofolate reductase.

Batruch I, Javasky E, Brown ED, Organ MG, Johnson PE. Batruch I, et al. Among authors: brown ed. Bioorg Med Chem. 2010 Dec 15;18(24):8485-92. doi: 10.1016/j.bmc.2010.10.048. Epub 2010 Oct 26. Bioorg Med Chem. 2010. PMID: 21084197

10

Chemical genomics in Escherichia coli identifies an inhibitor of bacterial lipoprotein targeting.

Pathania R, Zlitni S, Barker C, Das R, Gerritsma DA, Lebert J, Awuah E, Melacini G, Capretta FA, Brown ED. Pathania R, et al. Among authors: brown ed. Nat Chem Biol. 2009 Nov;5(11):849-56. doi: 10.1038/nchembio.221. Epub 2009 Sep 27. Nat Chem Biol. 2009. PMID: 19783991

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