Obika S - Search Results

1

Double-stranded DNA-templated cleavage of oligonucleotides containing a P3'->N5' linkage triggered by triplex formation: the effects of chemical modifications and remarkable enhancement in reactivity.

Ito KR, Kodama T, Tomizu M, Negoro Y, Orita A, Osaki T, Hosoki N, Tanaka T, Imanishi T, Obika S. Ito KR, et al. Among authors: obika s. Nucleic Acids Res. 2010 Nov;38(20):7332-42. doi: 10.1093/nar/gkq600. Epub 2010 Jul 8. Nucleic Acids Res. 2010. PMID: 20615902 Free PMC article.

2

Properties of cationic liposomes composed of cationic lipid YKS-220 having an ester linkage: adequate stability, high transfection efficiency, and low cytotoxicity.

Obika S, Yu W, Shimoyama A, Uneda T, Minami T, Miyashita K, Doi T, Imanishi T. Obika S, et al. Biol Pharm Bull. 1999 Feb;22(2):187-90. doi: 10.1248/bpb.22.187. Biol Pharm Bull. 1999. PMID: 10077439 Free article.

3

Preparation and properties of 2',5'-linked oligonucleotide analogues containing 3'-O,4'-C-methyleneribonucleosides.

Obika S, Morio K, Hari Y, Imanishi T. Obika S, et al. Bioorg Med Chem Lett. 1999 Feb 22;9(4):515-8. doi: 10.1016/s0960-894x(99)00028-1. Bioorg Med Chem Lett. 1999. PMID: 10098653

4

Gene transfer mediated by YKS-220 cationic particles: convenient and efficient gene delivery reagent.

Yu W, Shimoyama A, Uneda T, Obika S, Miyashita K, Doi T, Imanishi T. Yu W, et al. Among authors: obika s. J Biochem. 1999 Jun;125(6):1034-8. doi: 10.1093/oxfordjournals.jbchem.a022383. J Biochem. 1999. PMID: 10348904 Free article.

5

2'-O,4'-C-methylene bridged nucleic acid modification promotes pyrimidine motif triplex DNA formation at physiological pH: thermodynamic and kinetic studies.

Torigoe H, Hari Y, Sekiguchi M, Obika S, Imanishi T. Torigoe H, et al. Among authors: obika s. J Biol Chem. 2001 Jan 26;276(4):2354-60. doi: 10.1074/jbc.M007783200. Epub 2000 Oct 16. J Biol Chem. 2001. PMID: 11035027 Free article.

6

Symmetrical cationic triglycerides: an efficient synthesis and application to gene transfer.

Obika S, Yu W, Shimoyama A, Uneda T, Miyashita K, Doi T, Imanishi T. Obika S, et al. Bioorg Med Chem. 2001 Feb;9(2):245-54. doi: 10.1016/s0968-0896(00)00242-x. Bioorg Med Chem. 2001. PMID: 11249117

7

2'-O,4'-C-Methylene bridged nucleic acid (2',4'-BNA): synthesis and triplex-forming properties.

Obika S, Uneda T, Sugimoto T, Nanbu D, Minami T, Doi T, Imanishi T. Obika S, et al. Bioorg Med Chem. 2001 Apr;9(4):1001-11. doi: 10.1016/s0968-0896(00)00325-4. Bioorg Med Chem. 2001. PMID: 11354656

8

A 2',4'-Bridged Nucleic Acid Containing 2-Pyridone as a Nucleobase: Efficient Recognition of a C small middle dotG Interruption by Triplex Formation with a Pyrimidine Motif Part of this work was supported by a Grant-in-Aid for Scientific Research (B) (No. 12557201) from the Japan Society for the Promotion of Science.

Obika S, Hari Y, Sekiguchi M, Imanishi T. Obika S, et al. Angew Chem Int Ed Engl. 2001 Jun 1;40(11):2079-2081. Angew Chem Int Ed Engl. 2001. PMID: 11433449 No abstract available.

9

Promotion of triplex formation by 2'-O,4'-C-methylene bridged nucleic acid (2',4'-BNA) modification: thermodynamic and kinetic studies.

Torigoe H, Obika S, Imanishi T. Torigoe H, et al. Among authors: obika s. Nucleosides Nucleotides Nucleic Acids. 2001 Apr-Jul;20(4-7):1235-8. doi: 10.1081/NCN-100002525. Nucleosides Nucleotides Nucleic Acids. 2001. PMID: 11562992

10

A 3,4-epoxypiperidine structure as a novel and simple DNA-cleavage unit.

Miyashita K, Park M, Adachi S, Seki S, Obika S, Imanishi T. Miyashita K, et al. Among authors: obika s. Bioorg Med Chem Lett. 2002 Apr 8;12(7):1075-7. doi: 10.1016/s0960-894x(02)00085-9. Bioorg Med Chem Lett. 2002. PMID: 11909721

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