Hulme C - Search Results

1

Concise Two-Step Solution Phase Syntheses of four novel Dihydroquinazoline scaffolds.

Dietrich J, Kaiser C, Meurice N, Hulme C. Dietrich J, et al. Among authors: hulme c. Tetrahedron Lett. 2010 Jul 28;51(30):3951-3955. doi: 10.1016/j.tetlet.2010.05.108. Tetrahedron Lett. 2010. PMID: 20625451 Free PMC article.

2

Emerging molecular diversity from the intra-molecular Ugi reaction: iterative efficiency in medicinal chemistry.

Hulme C, Dietrich J. Hulme C, et al. Mol Divers. 2009 May;13(2):195-207. doi: 10.1007/s11030-009-9111-6. Epub 2009 Feb 11. Mol Divers. 2009. PMID: 19205916 Review.

3

Structural conservation in band 4.1, ezrin, radixin, moesin (FERM) domains as a guide to identify inhibitors of the proline-rich tyrosine kinase 2.

Meurice N, Wang L, Lipinski CA, Yang Z, Hulme C, Loftus JC. Meurice N, et al. Among authors: hulme c. J Med Chem. 2010 Jan 28;53(2):669-77. doi: 10.1021/jm901247a. J Med Chem. 2010. PMID: 20017492 Free PMC article.

4

The design, synthesis, and evaluation of 8 hybrid DFG-out allosteric kinase inhibitors: a structural analysis of the binding interactions of Gleevec, Nexavar, and BIRB-796.

Dietrich J, Hulme C, Hurley LH. Dietrich J, et al. Among authors: hulme c. Bioorg Med Chem. 2010 Aug 1;18(15):5738-48. doi: 10.1016/j.bmc.2010.05.063. Epub 2010 Jun 4. Bioorg Med Chem. 2010. PMID: 20621496

5

Two step syntheses of fused quinoxaline-benzodiazepines and bis-benzodiazepines.

Xu Z, Dietrich J, Shaw AY, Hulme C. Xu Z, et al. Among authors: hulme c. Tetrahedron Lett. 2010 Aug 25;51(34):4566-4569. doi: 10.1016/j.tetlet.2010.06.116. Tetrahedron Lett. 2010. PMID: 20706616 Free PMC article.

6

Concise Preparation of Novel Tricyclic Chemotypes: Fused Hydantoin-benzodiazepines.

Gunawan S, Nichol GS, Chappeta S, Dietrich J, Hulme C. Gunawan S, et al. Among authors: hulme c. Tetrahedron Lett. 2010 Sep 8;51(36):4689-4692. doi: 10.1016/j.tetlet.2010.06.131. Tetrahedron Lett. 2010. PMID: 20802841 Free PMC article.

7

4-(Piperidin-1-yl)-4H-benzo[b]tetra-zolo[1,5-d][1,4]diazepin-5(6H)-one.

Nichol GS, Xu Z, Kaiser CE, Hulme C. Nichol GS, et al. Among authors: hulme c. Acta Crystallogr Sect E Struct Rep Online. 2010 Dec 4;67(Pt 1):o23-4. doi: 10.1107/S1600536810049950. Acta Crystallogr Sect E Struct Rep Online. 2010. PMID: 21522729 Free PMC article.

8

2-Propyl 3,3-dibromo-2-hydroxy-pyrrolidine-1-carboxyl-ate.

Nichol GS, Gunawan S, Xu Z, Dietrich J, Hulme C. Nichol GS, et al. Among authors: hulme c. Acta Crystallogr Sect E Struct Rep Online. 2010 Feb 13;66(Pt 3):o597. doi: 10.1107/S1600536810005106. Acta Crystallogr Sect E Struct Rep Online. 2010. PMID: 21580358 Free PMC article.

9

2-Butyl-11-phenyl-5,10-dihydro-1H-benzo[e]imidazo[1,5-a][1,4]diazepine-1,3(2H)-dione.

Nichol GS, Gunawan S, Dietrich J, Hulme C. Nichol GS, et al. Among authors: hulme c. Acta Crystallogr Sect E Struct Rep Online. 2010 Feb 13;66(Pt 3):o625. doi: 10.1107/S1600536810005477. Acta Crystallogr Sect E Struct Rep Online. 2010. PMID: 21580382 Free PMC article.

10

A novel route to synthesize libraries of quinoxalines via Petasis methodology in two synthetic operations.

Ayaz M, Dietrich J, Hulme C. Ayaz M, et al. Among authors: hulme c. Tetrahedron Lett. 2011 Sep 21;52(38):4821-4823. doi: 10.1016/j.tetlet.2011.06.115. Tetrahedron Lett. 2011. PMID: 21987596 Free PMC article.

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