Coghi P - Search Results

1

Facile oxidation of leucomethylene blue and dihydroflavins by artemisinins: relationship with flavoenzyme function and antimalarial mechanism of action.

Haynes RK, Chan WC, Wong HN, Li KY, Wu WK, Fan KM, Sung HH, Williams ID, Prosperi D, Melato S, Coghi P, Monti D. Haynes RK, et al. Among authors: coghi p. ChemMedChem. 2010 Aug 2;5(8):1282-99. doi: 10.1002/cmdc.201000225. ChemMedChem. 2010. PMID: 20629071

2

A combinatorial approach to 2,4,6-trisubstituted triazines with potent antimalarial activity: combining conventional synthesis and microwave-assistance.

Melato S, Prosperi D, Coghi P, Basilico N, Monti D. Melato S, et al. Among authors: coghi p. ChemMedChem. 2008 Jun;3(6):873-6. doi: 10.1002/cmdc.200700344. ChemMedChem. 2008. PMID: 18297663 No abstract available.

3

Interaction of artemisinins with oxyhemoglobin Hb-FeII, Hb-FeII, carboxyHb-FeII, heme-FeII, and carboxyheme FeII: significance for mode of action and implications for therapy of cerebral malaria.

Coghi P, Basilico N, Taramelli D, Chan WC, Haynes RK, Monti D. Coghi P, et al. ChemMedChem. 2009 Dec;4(12):2045-53. doi: 10.1002/cmdc.200900342. ChemMedChem. 2009. PMID: 19844934

4

Reactions of antimalarial peroxides with each of leucomethylene blue and dihydroflavins: flavin reductase and the cofactor model exemplified.

Haynes RK, Cheu KW, Tang MM, Chen MJ, Guo ZF, Guo ZH, Coghi P, Monti D. Haynes RK, et al. Among authors: coghi p. ChemMedChem. 2011 Feb 7;6(2):279-91. doi: 10.1002/cmdc.201000508. Epub 2010 Dec 23. ChemMedChem. 2011. PMID: 21275052

5

A partial convergence in action of methylene blue and artemisinins: antagonism with chloroquine, a reversal with verapamil, and an insight into the antimalarial activity of chloroquine.

Haynes RK, Cheu KW, Li KY, Tang MM, Wong HN, Chen MJ, Guo ZF, Guo ZH, Coghi P, Monti D. Haynes RK, et al. Among authors: coghi p. ChemMedChem. 2011 Sep 5;6(9):1603-15. doi: 10.1002/cmdc.201100184. Epub 2011 Jul 11. ChemMedChem. 2011. PMID: 21994127

6

Interactions between artemisinins and other antimalarial drugs in relation to the cofactor model--a unifying proposal for drug action.

Haynes RK, Cheu KW, Chan HW, Wong HN, Li KY, Tang MM, Chen MJ, Guo ZF, Guo ZH, Sinniah K, Witte AB, Coghi P, Monti D. Haynes RK, et al. Among authors: coghi p. ChemMedChem. 2012 Dec;7(12):2204-26. doi: 10.1002/cmdc.201200383. Epub 2012 Oct 30. ChemMedChem. 2012. PMID: 23112085

7

Considerations on the mechanism of action of artemisinin antimalarials: part 1--the 'carbon radical' and 'heme' hypotheses.

Haynes RK, Cheu KW, N'Da D, Coghi P, Monti D. Haynes RK, et al. Among authors: coghi p. Infect Disord Drug Targets. 2013 Aug;13(4):217-77. doi: 10.2174/1871526513666131129155708. Infect Disord Drug Targets. 2013. PMID: 24304352 Review.

8

A Drug Repurposing Approach for Antimalarials Interfering with SARS-CoV-2 Spike Protein Receptor Binding Domain (RBD) and Human Angiotensin-Converting Enzyme 2 (ACE2).

Coghi P, Yang LJ, Ng JPL, Haynes RK, Memo M, Gianoncelli A, Wong VKW, Ribaudo G. Coghi P, et al. Pharmaceuticals (Basel). 2021 Sep 23;14(10):954. doi: 10.3390/ph14100954. Pharmaceuticals (Basel). 2021. PMID: 34681178 Free PMC article.

9

Antimalarial and antitumour activities of the steroidal quinone-methide celastrol and its combinations with artemiside, artemisone and methylene blue.

Ng JPL, Han Y, Yang LJ, Birkholtz LM, Coertzen D, Wong HN, Haynes RK, Coghi P, Wong VKW. Ng JPL, et al. Among authors: coghi p. Front Pharmacol. 2022 Sep 2;13:988748. doi: 10.3389/fphar.2022.988748. eCollection 2022. Front Pharmacol. 2022. PMID: 36120293 Free PMC article.

10

Combining computational and experimental evidence on the activity of antimalarial drugs on papain-like protease of SARS-CoV-2: A repurposing study.

Ribaudo G, Yun X, Ongaro A, Oselladore E, Ng JPL, Haynes RK, Law BYK, Memo M, Wong VKW, Coghi P, Gianoncelli A. Ribaudo G, et al. Among authors: coghi p. Chem Biol Drug Des. 2023 Apr;101(4):809-818. doi: 10.1111/cbdd.14187. Epub 2022 Dec 14. Chem Biol Drug Des. 2023. PMID: 36453012

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