Haynes RK - Search Results

1

Facile oxidation of leucomethylene blue and dihydroflavins by artemisinins: relationship with flavoenzyme function and antimalarial mechanism of action.

Haynes RK, Chan WC, Wong HN, Li KY, Wu WK, Fan KM, Sung HH, Williams ID, Prosperi D, Melato S, Coghi P, Monti D. Haynes RK, et al. ChemMedChem. 2010 Aug 2;5(8):1282-99. doi: 10.1002/cmdc.201000225. ChemMedChem. 2010. PMID: 20629071

2

Artesunate and dihydroartemisinin (DHA): unusual decomposition products formed under mild conditions and comments on the fitness of DHA as an antimalarial drug.

Haynes RK, Chan HW, Lung CM, Ng NC, Wong HN, Shek LY, Williams ID, Cartwright A, Gomes MF. Haynes RK, et al. ChemMedChem. 2007 Oct;2(10):1448-63. doi: 10.1002/cmdc.200700064. ChemMedChem. 2007. PMID: 17694524

3

Preparation of N-sulfonyl- and N-carbonyl-11-azaartemisinins with greatly enhanced thermal stabilities: in vitro antimalarial activities.

Haynes RK, Wong HN, Lee KW, Lung CM, Shek LY, Williams ID, Croft SL, Vivas L, Rattray L, Stewart L, Wong VK, Ko BC. Haynes RK, et al. ChemMedChem. 2007 Oct;2(10):1464-79. doi: 10.1002/cmdc.200700065. ChemMedChem. 2007. PMID: 17768731

4

The Fe2+-mediated decomposition, PfATP6 binding, and antimalarial activities of artemisone and other artemisinins: the unlikelihood of C-centered radicals as bioactive intermediates.

Haynes RK, Chan WC, Lung CM, Uhlemann AC, Eckstein U, Taramelli D, Parapini S, Monti D, Krishna S. Haynes RK, et al. ChemMedChem. 2007 Oct;2(10):1480-97. doi: 10.1002/cmdc.200700108. ChemMedChem. 2007. PMID: 17768732 Free article.

5

Interaction of artemisinins with oxyhemoglobin Hb-FeII, Hb-FeII, carboxyHb-FeII, heme-FeII, and carboxyheme FeII: significance for mode of action and implications for therapy of cerebral malaria.

Coghi P, Basilico N, Taramelli D, Chan WC, Haynes RK, Monti D. Coghi P, et al. Among authors: haynes rk. ChemMedChem. 2009 Dec;4(12):2045-53. doi: 10.1002/cmdc.200900342. ChemMedChem. 2009. PMID: 19844934

6

Reactions of antimalarial peroxides with each of leucomethylene blue and dihydroflavins: flavin reductase and the cofactor model exemplified.

Haynes RK, Cheu KW, Tang MM, Chen MJ, Guo ZF, Guo ZH, Coghi P, Monti D. Haynes RK, et al. ChemMedChem. 2011 Feb 7;6(2):279-91. doi: 10.1002/cmdc.201000508. Epub 2010 Dec 23. ChemMedChem. 2011. PMID: 21275052

7

A partial convergence in action of methylene blue and artemisinins: antagonism with chloroquine, a reversal with verapamil, and an insight into the antimalarial activity of chloroquine.

Haynes RK, Cheu KW, Li KY, Tang MM, Wong HN, Chen MJ, Guo ZF, Guo ZH, Coghi P, Monti D. Haynes RK, et al. ChemMedChem. 2011 Sep 5;6(9):1603-15. doi: 10.1002/cmdc.201100184. Epub 2011 Jul 11. ChemMedChem. 2011. PMID: 21994127

8

Interactions between artemisinins and other antimalarial drugs in relation to the cofactor model--a unifying proposal for drug action.

Haynes RK, Cheu KW, Chan HW, Wong HN, Li KY, Tang MM, Chen MJ, Guo ZF, Guo ZH, Sinniah K, Witte AB, Coghi P, Monti D. Haynes RK, et al. ChemMedChem. 2012 Dec;7(12):2204-26. doi: 10.1002/cmdc.201200383. Epub 2012 Oct 30. ChemMedChem. 2012. PMID: 23112085

9

Methylene Homologues of Artemisone: An Unexpected Structure-Activity Relationship and a Possible Implication for the Design of C10-Substituted Artemisinins.

Wu Y, Wu RW, Cheu KW, Williams ID, Krishna S, Slavic K, Gravett AM, Liu WM, Wong HN, Haynes RK. Wu Y, et al. Among authors: haynes rk. ChemMedChem. 2016 Jul 5;11(13):1469-79. doi: 10.1002/cmdc.201600011. Epub 2016 Jun 7. ChemMedChem. 2016. PMID: 27273875

10

Considerations on the mechanism of action of artemisinin antimalarials: part 1--the 'carbon radical' and 'heme' hypotheses.

Haynes RK, Cheu KW, N'Da D, Coghi P, Monti D. Haynes RK, et al. Infect Disord Drug Targets. 2013 Aug;13(4):217-77. doi: 10.2174/1871526513666131129155708. Infect Disord Drug Targets. 2013. PMID: 24304352 Review.

Save citations to file

Email citations

Send citations to clipboard

Add to Collections

Add to My Bibliography

Create a file for external citation management software

Your saved search

Your RSS Feed

My Custom Filters

Publication date

Text availability

Article attribute

Article type

Article Language

Species

Sex

Age

Other

102 results

Search Page

Filters