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Receptor for AGEs (RAGE) blockade may exert its renoprotective effects in patients with diabetic nephropathy via induction of the angiotensin II type 2 (AT2) receptor.
Sourris KC, Morley AL, Koitka A, Samuel P, Coughlan MT, Penfold SA, Thomas MC, Bierhaus A, Nawroth PP, Yamamoto H, Allen TJ, Walther T, Hussain T, Cooper ME, Forbes JM. Sourris KC, et al. Among authors: samuel p. Diabetologia. 2010 Nov;53(11):2442-51. doi: 10.1007/s00125-010-1837-2. Epub 2010 Jul 15. Diabetologia. 2010. PMID: 20631980 Free PMC article.
Angiotensin type 2 receptor null mice express reduced levels of renal angiotensin II type 2 receptor/angiotensin (1-7)/Mas receptor and exhibit greater high-fat diet-induced kidney injury.
Ali Q, Dhande I, Samuel P, Hussain T. Ali Q, et al. Among authors: samuel p. J Renin Angiotensin Aldosterone Syst. 2016 Aug 5;17(3):1470320316661871. doi: 10.1177/1470320316661871. Print 2016 Jul. J Renin Angiotensin Aldosterone Syst. 2016. PMID: 27496559 Free PMC article.
450 results