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Motesanib inhibits Kit mutations associated with gastrointestinal stromal tumors.
Caenepeel S, Renshaw-Gegg L, Baher A, Bush TL, Baron W, Juan T, Manoukian R, Tasker AS, Polverino A, Hughes PE. Caenepeel S, et al. Among authors: manoukian r. J Exp Clin Cancer Res. 2010 Jul 15;29(1):96. doi: 10.1186/1756-9966-29-96. J Exp Clin Cancer Res. 2010. PMID: 20633291 Free PMC article.
An antibody to IP-10 is a potent antagonist of cell migration in vitro and in vivo and does not affect disease in several animal models of inflammation.
Byrne FR, Winters A, Brankow D, Hu S, Juan T, Steavenson S, Doellgast G, Kuchimanchi K, Brown H, Anderson S, Smelt S, Sullivan T, Alcorn D, Tocker J, Dean C Jr, Macmaster J, Kirchner J, Buys J, Manoukian R, Jiao E, Zou X, Campanella GS, Siu G. Byrne FR, et al. Among authors: manoukian r. Autoimmunity. 2009 Mar;42(3):171-82. doi: 10.1080/08916930802629547. Autoimmunity. 2009. PMID: 19301198
Small-molecule inhibition of kinesin KIF18A reveals a mitotic vulnerability enriched in chromosomally unstable cancers.
Payton M, Belmontes B, Hanestad K, Moriguchi J, Chen K, McCarter JD, Chung G, Ninniri MS, Sun J, Manoukian R, Chambers S, Ho SM, Kurzeja RJM, Edson KZ, Dahal UP, Wu T, Wannberg S, Beltran PJ, Canon J, Boghossian AS, Rees MG, Ronan MM, Roth JA, Minocherhomji S, Bourbeau MP, Allen JR, Coxon A, Tamayo NA, Hughes PE. Payton M, et al. Among authors: manoukian r. Nat Cancer. 2024 Jan;5(1):66-84. doi: 10.1038/s43018-023-00699-5. Epub 2023 Dec 27. Nat Cancer. 2024. PMID: 38151625 Free PMC article.
Antagonism of Ang-Tie2 and Dll4-Notch signaling has opposing effects on tumor endothelial cell proliferation, evidenced by a new flow cytometry method.
Payton M, Jun T, Wayne W, Yu D, Manoukian R, Chung G, Zhang N, Sun JR, Kaplan-Lefko P, Scully S, Van G, Radinsky R, Kendall R, Oliner J, Coxon A. Payton M, et al. Among authors: manoukian r. Lab Invest. 2014 Nov;94(11):1296-308. doi: 10.1038/labinvest.2014.116. Epub 2014 Sep 22. Lab Invest. 2014. PMID: 25243900 Free article.
Functional and Nonclinical Similarity of ABP 980, a Biosimilar of Trastuzumab.
Jassem S, Wang W, Sweet H, Manoukian R, Chow V, Kanakaraj P, Hutterer KM, Kuhns S, Foltz IN, Chen Q, Ferbas J, McBride HJ. Jassem S, et al. Among authors: manoukian r. Pharm Res. 2019 Nov 6;36(12):177. doi: 10.1007/s11095-019-2702-8. Pharm Res. 2019. PMID: 31696314 Free PMC article.
Polyglutamine repeat length-dependent proteolysis of huntingtin.
Sun B, Fan W, Balciunas A, Cooper JK, Bitan G, Steavenson S, Denis PE, Young Y, Adler B, Daugherty L, Manoukian R, Elliott G, Shen W, Talvenheimo J, Teplow DB, Haniu M, Haldankar R, Wypych J, Ross CA, Citron M, Richards WG. Sun B, et al. Among authors: manoukian r. Neurobiol Dis. 2002 Oct;11(1):111-22. doi: 10.1006/nbdi.2002.0539. Neurobiol Dis. 2002. PMID: 12460551
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