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5-Lipoxygenase metabolite 4-HDHA is a mediator of the antiangiogenic effect of ω-3 polyunsaturated fatty acids.
Sapieha P, Stahl A, Chen J, Seaward MR, Willett KL, Krah NM, Dennison RJ, Connor KM, Aderman CM, Liclican E, Carughi A, Perelman D, Kanaoka Y, Sangiovanni JP, Gronert K, Smith LE. Sapieha P, et al. Among authors: sangiovanni jp. Sci Transl Med. 2011 Feb 9;3(69):69ra12. doi: 10.1126/scitranslmed.3001571. Sci Transl Med. 2011. PMID: 21307302 Free PMC article.
DNA sequence variants in PPARGC1A, a gene encoding a coactivator of the ω-3 LCPUFA sensing PPAR-RXR transcription complex, are associated with NV AMD and AMD-associated loci in genes of complement and VEGF signaling pathways.
SanGiovanni JP, Chen J, Sapieha P, Aderman CM, Stahl A, Clemons TE, Chew EY, Smith LE. SanGiovanni JP, et al. PLoS One. 2013;8(1):e53155. doi: 10.1371/journal.pone.0053155. Epub 2013 Jan 15. PLoS One. 2013. PMID: 23335958 Free PMC article.
Omega-3 supplementation combined with anti-vascular endothelial growth factor lowers vitreal levels of vascular endothelial growth factor in wet age-related macular degeneration.
Rezende FA, Lapalme E, Qian CX, Smith LE, SanGiovanni JP, Sapieha P. Rezende FA, et al. Among authors: sangiovanni jp. Am J Ophthalmol. 2014 Nov;158(5):1071-78. doi: 10.1016/j.ajo.2014.07.036. Epub 2014 Aug 1. Am J Ophthalmol. 2014. PMID: 25089351 Free PMC article. Clinical Trial.
Dietary ω-3 polyunsaturated fatty acids decrease retinal neovascularization by adipose-endoplasmic reticulum stress reduction to increase adiponectin.
Fu Z, Lofqvist CA, Shao Z, Sun Y, Joyal JS, Hurst CG, Cui RZ, Evans LP, Tian K, SanGiovanni JP, Chen J, Ley D, Hansen Pupp I, Hellstrom A, Smith LE. Fu Z, et al. Among authors: sangiovanni jp. Am J Clin Nutr. 2015 Apr;101(4):879-88. doi: 10.3945/ajcn.114.099291. Epub 2015 Feb 4. Am J Clin Nutr. 2015. PMID: 25833984 Free PMC article.
70 results