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Overexpression of Mn superoxide dismutase does not increase life span in mice.
Jang YC, Pérez VI, Song W, Lustgarten MS, Salmon AB, Mele J, Qi W, Liu Y, Liang H, Chaudhuri A, Ikeno Y, Epstein CJ, Van Remmen H, Richardson A. Jang YC, et al. Among authors: qi w. J Gerontol A Biol Sci Med Sci. 2009 Nov;64(11):1114-25. doi: 10.1093/gerona/glp100. Epub 2009 Jul 24. J Gerontol A Biol Sci Med Sci. 2009. PMID: 19633237 Free PMC article.
MnSOD deficiency results in elevated oxidative stress and decreased mitochondrial function but does not lead to muscle atrophy during aging.
Lustgarten MS, Jang YC, Liu Y, Qi W, Qin Y, Dahia PL, Shi Y, Bhattacharya A, Muller FL, Shimizu T, Shirasawa T, Richardson A, Van Remmen H. Lustgarten MS, et al. Among authors: qi w. Aging Cell. 2011 Jun;10(3):493-505. doi: 10.1111/j.1474-9726.2011.00695.x. Epub 2011 Apr 5. Aging Cell. 2011. PMID: 21385310 Free PMC article.
Dietary restriction attenuates the accelerated aging phenotype of Sod1(-/-) mice.
Zhang Y, Ikeno Y, Bokov A, Gelfond J, Jaramillo C, Zhang HM, Liu Y, Qi W, Hubbard G, Richardson A, Van Remmen H. Zhang Y, et al. Among authors: qi w. Free Radic Biol Med. 2013 Jul;60:300-6. doi: 10.1016/j.freeradbiomed.2013.02.026. Epub 2013 Feb 28. Free Radic Biol Med. 2013. PMID: 23459073 Free PMC article.
Mice deficient in both Mn superoxide dismutase and glutathione peroxidase-1 have increased oxidative damage and a greater incidence of pathology but no reduction in longevity.
Zhang Y, Ikeno Y, Qi W, Chaudhuri A, Li Y, Bokov A, Thorpe SR, Baynes JW, Epstein C, Richardson A, Van Remmen H. Zhang Y, et al. Among authors: qi w. J Gerontol A Biol Sci Med Sci. 2009 Dec;64(12):1212-20. doi: 10.1093/gerona/glp132. Epub 2009 Sep 23. J Gerontol A Biol Sci Med Sci. 2009. PMID: 19776219 Free PMC article.
Conditional knockout of Mn-SOD targeted to type IIB skeletal muscle fibers increases oxidative stress and is sufficient to alter aerobic exercise capacity.
Lustgarten MS, Jang YC, Liu Y, Muller FL, Qi W, Steinhelper M, Brooks SV, Larkin L, Shimizu T, Shirasawa T, McManus LM, Bhattacharya A, Richardson A, Van Remmen H. Lustgarten MS, et al. Among authors: qi w. Am J Physiol Cell Physiol. 2009 Dec;297(6):C1520-32. doi: 10.1152/ajpcell.00372.2009. Epub 2009 Sep 23. Am J Physiol Cell Physiol. 2009. PMID: 19776389 Free PMC article.
3,620 results