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Epigenetic silencing of a proapoptotic cell adhesion molecule, the immunoglobulin superfamily member IGSF4, by promoter CpG methylation protects Hodgkin lymphoma cells from apoptosis.
Murray PG, Fan Y, Davies G, Ying J, Geng H, Ng KM, Li H, Gao Z, Wei W, Bose S, Anderton J, Kapatai G, Reynolds G, Ito A, Marafioti T, Woodman CB, Ambinder R, Tao Q. Murray PG, et al. Among authors: fan y. Am J Pathol. 2010 Sep;177(3):1480-90. doi: 10.2353/ajpath.2010.100052. Epub 2010 Aug 13. Am J Pathol. 2010. PMID: 20709797 Free PMC article.
The new 6q27 tumor suppressor DACT2, frequently silenced by CpG methylation, sensitizes nasopharyngeal cancer cells to paclitaxel and 5-FU toxicity via β-catenin/Cdc25c signaling and G2/M arrest.
Zhang Y, Fan J, Fan Y, Li L, He X, Xiang Q, Mu J, Zhou D, Sun X, Yang Y, Ren G, Tao Q, Xiang T. Zhang Y, et al. Among authors: fan j, fan y. Clin Epigenetics. 2018 Feb 27;10(1):26. doi: 10.1186/s13148-018-0459-2. Clin Epigenetics. 2018. PMID: 30359298 Free PMC article.
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