El Turk F - Search Results

1

An integrative in silico methodology for the identification of modulators of macrophage migration inhibitory factor (MIF) tautomerase activity.

El Turk F, Fauvet B, Ouertatani-Sakouhi H, Lugari A, Betzi S, Roche P, Morelli X, Lashuel HA. El Turk F, et al. Bioorg Med Chem. 2010 Jul 15;18(14):5425-40. doi: 10.1016/j.bmc.2010.05.010. Epub 2010 May 13. Bioorg Med Chem. 2010. PMID: 20639113 Free article.

2

The conformational flexibility of the carboxy terminal residues 105-114 is a key modulator of the catalytic activity and stability of macrophage migration inhibitory factor.

El-Turk F, Cascella M, Ouertatani-Sakouhi H, Narayanan RL, Leng L, Bucala R, Zweckstetter M, Rothlisberger U, Lashuel HA. El-Turk F, et al. Biochemistry. 2008 Oct 7;47(40):10740-56. doi: 10.1021/bi800603x. Epub 2008 Sep 17. Biochemistry. 2008. PMID: 18795803 Free PMC article.

3

A new class of isothiocyanate-based irreversible inhibitors of macrophage migration inhibitory factor.

Ouertatani-Sakouhi H, El-Turk F, Fauvet B, Roger T, Le Roy D, Karpinar DP, Leng L, Bucala R, Zweckstetter M, Calandra T, Lashuel HA. Ouertatani-Sakouhi H, et al. Among authors: el turk f. Biochemistry. 2009 Oct 20;48(41):9858-70. doi: 10.1021/bi900957e. Biochemistry. 2009. PMID: 19737008 Free PMC article.

4

Kinetic-based high-throughput screening assay to discover novel classes of macrophage migration inhibitory factor inhibitors.

Ouertatani-Sakouhi H, Liu M, El-Turk F, Cuny GD, Glicksman MA, Lashuel HA. Ouertatani-Sakouhi H, et al. Among authors: el turk f. J Biomol Screen. 2010 Apr;15(4):347-58. doi: 10.1177/1087057110363825. Epub 2010 Mar 15. J Biomol Screen. 2010. PMID: 20231420

5

Identification and characterization of novel classes of macrophage migration inhibitory factor (MIF) inhibitors with distinct mechanisms of action.

Ouertatani-Sakouhi H, El-Turk F, Fauvet B, Cho MK, Pinar Karpinar D, Le Roy D, Dewor M, Roger T, Bernhagen J, Calandra T, Zweckstetter M, Lashuel HA. Ouertatani-Sakouhi H, et al. Among authors: el turk f. J Biol Chem. 2010 Aug 20;285(34):26581-98. doi: 10.1074/jbc.M110.113951. Epub 2010 Jun 1. J Biol Chem. 2010. PMID: 20516071 Free PMC article.

6

Characterization of molecular determinants of the conformational stability of macrophage migration inhibitory factor: leucine 46 hydrophobic pocket.

El-Turk F, Fauvet B, Ashrafi A, Ouertatani-Sakouhi H, Cho MK, Neri M, Cascella M, Rothlisberger U, Pojer F, Zweckstetter M, Lashuel H. El-Turk F, et al. PLoS One. 2012;7(9):e45024. doi: 10.1371/journal.pone.0045024. Epub 2012 Sep 21. PLoS One. 2012. PMID: 23028743 Free PMC article.

7

Exploring the role of post-translational modifications in regulating α-synuclein interactions by studying the effects of phosphorylation on nanobody binding.

El Turk F, De Genst E, Guilliams T, Fauvet B, Hejjaoui M, Di Trani J, Chiki A, Mittermaier A, Vendruscolo M, Lashuel HA, Dobson CM. El Turk F, et al. Protein Sci. 2018 Jul;27(7):1262-1274. doi: 10.1002/pro.3412. Protein Sci. 2018. PMID: 29603451 Free PMC article.

8

Semisynthetic and in Vitro Phosphorylation of Alpha-Synuclein at Y39 Promotes Functional Partly Helical Membrane-Bound States Resembling Those Induced by PD Mutations.

Dikiy I, Fauvet B, Jovičić A, Mahul-Mellier AL, Desobry C, El-Turk F, Gitler AD, Lashuel HA, Eliezer D. Dikiy I, et al. Among authors: el turk f. ACS Chem Biol. 2016 Sep 16;11(9):2428-37. doi: 10.1021/acschembio.6b00539. Epub 2016 Jul 11. ACS Chem Biol. 2016. PMID: 27356045 Free PMC article.

9

Structural Effects of Two Camelid Nanobodies Directed to Distinct C-Terminal Epitopes on α-Synuclein.

El-Turk F, Newby FN, De Genst E, Guilliams T, Sprules T, Mittermaier A, Dobson CM, Vendruscolo M. El-Turk F, et al. Biochemistry. 2016 Jun 7;55(22):3116-22. doi: 10.1021/acs.biochem.6b00149. Epub 2016 May 26. Biochemistry. 2016. PMID: 27096466

10

Nanobodies raised against monomeric α-synuclein distinguish between fibrils at different maturation stages.

Guilliams T, El-Turk F, Buell AK, O'Day EM, Aprile FA, Esbjörner EK, Vendruscolo M, Cremades N, Pardon E, Wyns L, Welland ME, Steyaert J, Christodoulou J, Dobson CM, De Genst E. Guilliams T, et al. Among authors: el turk f. J Mol Biol. 2013 Jul 24;425(14):2397-411. doi: 10.1016/j.jmb.2013.01.040. Epub 2013 Apr 1. J Mol Biol. 2013. PMID: 23557833 Free article.

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