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Mitochondria in the diabetic heart.
Bugger H, Abel ED. Bugger H, et al. Cardiovasc Res. 2010 Nov 1;88(2):229-40. doi: 10.1093/cvr/cvq239. Epub 2010 Jul 16. Cardiovasc Res. 2010. PMID: 20639213 Free PMC article. Review.
Molecular mechanisms of diabetic cardiomyopathy.
Bugger H, Abel ED. Bugger H, et al. Diabetologia. 2014 Apr;57(4):660-71. doi: 10.1007/s00125-014-3171-6. Epub 2014 Jan 30. Diabetologia. 2014. PMID: 24477973 Free PMC article. Review.
Mitochondrial Reactive Oxygen Species in Lipotoxic Hearts Induce Post-Translational Modifications of AKAP121, DRP1, and OPA1 That Promote Mitochondrial Fission.
Tsushima K, Bugger H, Wende AR, Soto J, Jenson GA, Tor AR, McGlauflin R, Kenny HC, Zhang Y, Souvenir R, Hu XX, Sloan CL, Pereira RO, Lira VA, Spitzer KW, Sharp TL, Shoghi KI, Sparagna GC, Rog-Zielinska EA, Kohl P, Khalimonchuk O, Schaffer JE, Abel ED. Tsushima K, et al. Among authors: bugger h. Circ Res. 2018 Jan 5;122(1):58-73. doi: 10.1161/CIRCRESAHA.117.311307. Epub 2017 Nov 1. Circ Res. 2018. PMID: 29092894 Free PMC article.
Animal Models of Dysregulated Cardiac Metabolism.
Bugger H, Byrne NJ, Abel ED. Bugger H, et al. Circ Res. 2022 Jun 10;130(12):1965-1993. doi: 10.1161/CIRCRESAHA.122.320334. Epub 2022 Jun 9. Circ Res. 2022. PMID: 35679363 Free PMC article. Review.
PGC-1β deficiency accelerates the transition to heart failure in pressure overload hypertrophy.
Riehle C, Wende AR, Zaha VG, Pires KM, Wayment B, Olsen C, Bugger H, Buchanan J, Wang X, Moreira AB, Doenst T, Medina-Gomez G, Litwin SE, Lelliott CJ, Vidal-Puig A, Abel ED. Riehle C, et al. Among authors: bugger h. Circ Res. 2011 Sep 16;109(7):783-93. doi: 10.1161/CIRCRESAHA.111.243964. Epub 2011 Jul 28. Circ Res. 2011. PMID: 21799152 Free PMC article.
Insulin receptor substrate signaling suppresses neonatal autophagy in the heart.
Riehle C, Wende AR, Sena S, Pires KM, Pereira RO, Zhu Y, Bugger H, Frank D, Bevins J, Chen D, Perry CN, Dong XC, Valdez S, Rech M, Sheng X, Weimer BC, Gottlieb RA, White MF, Abel ED. Riehle C, et al. Among authors: bugger h. J Clin Invest. 2013 Dec;123(12):5319-33. doi: 10.1172/JCI71171. Epub 2013 Nov 1. J Clin Invest. 2013. PMID: 24177427 Free PMC article.
Enhanced cardiac Akt/protein kinase B signaling contributes to pathological cardiac hypertrophy in part by impairing mitochondrial function via transcriptional repression of mitochondrion-targeted nuclear genes.
Wende AR, O'Neill BT, Bugger H, Riehle C, Tuinei J, Buchanan J, Tsushima K, Wang L, Caro P, Guo A, Sloan C, Kim BJ, Wang X, Pereira RO, McCrory MA, Nye BG, Benavides GA, Darley-Usmar VM, Shioi T, Weimer BC, Abel ED. Wende AR, et al. Among authors: bugger h. Mol Cell Biol. 2015 Mar;35(5):831-46. doi: 10.1128/MCB.01109-14. Epub 2014 Dec 22. Mol Cell Biol. 2015. PMID: 25535334 Free PMC article.
Myocardial mitochondrial dysfunction in mice lacking adiponectin receptor 1.
Koentges C, König A, Pfeil K, Hölscher ME, Schnick T, Wende AR, Schrepper A, Cimolai MC, Kersting S, Hoffmann MM, Asal J, Osterholt M, Odening KE, Doenst T, Hein L, Abel ED, Bode C, Bugger H. Koentges C, et al. Among authors: bugger h. Basic Res Cardiol. 2015;110(4):37. doi: 10.1007/s00395-015-0495-4. Epub 2015 May 16. Basic Res Cardiol. 2015. PMID: 25982881
Antioxidant treatment normalizes mitochondrial energetics and myocardial insulin sensitivity independently of changes in systemic metabolic homeostasis in a mouse model of the metabolic syndrome.
Ilkun O, Wilde N, Tuinei J, Pires KM, Zhu Y, Bugger H, Soto J, Wayment B, Olsen C, Litwin SE, Abel ED. Ilkun O, et al. Among authors: bugger h. J Mol Cell Cardiol. 2015 Aug;85:104-16. doi: 10.1016/j.yjmcc.2015.05.012. Epub 2015 May 22. J Mol Cell Cardiol. 2015. PMID: 26004364 Free PMC article.
95 results