Kusaka M - Search Results

1

Overcoming persistent dependency on androgen signaling after progression to castration-resistant prostate cancer.

Yamaoka M, Hara T, Kusaka M. Yamaoka M, et al. Among authors: kusaka m. Clin Cancer Res. 2010 Sep 1;16(17):4319-24. doi: 10.1158/1078-0432.CCR-10-0255. Epub 2010 Jul 20. Clin Cancer Res. 2010. PMID: 20647476 Review.

2

Novel mutations of androgen receptor: a possible mechanism of bicalutamide withdrawal syndrome.

Hara T, Miyazaki J, Araki H, Yamaoka M, Kanzaki N, Kusaka M, Miyamoto M. Hara T, et al. Among authors: kusaka m. Cancer Res. 2003 Jan 1;63(1):149-53. Cancer Res. 2003. PMID: 12517791

3

Enhanced androgen receptor signaling correlates with the androgen-refractory growth in a newly established MDA PCa 2b-hr human prostate cancer cell subline.

Hara T, Nakamura K, Araki H, Kusaka M, Yamaoka M. Hara T, et al. Among authors: kusaka m. Cancer Res. 2003 Sep 1;63(17):5622-8. Cancer Res. 2003. PMID: 14500404

4

Orteronel (TAK-700), a novel non-steroidal 17,20-lyase inhibitor: effects on steroid synthesis in human and monkey adrenal cells and serum steroid levels in cynomolgus monkeys.

Yamaoka M, Hara T, Hitaka T, Kaku T, Takeuchi T, Takahashi J, Asahi S, Miki H, Tasaka A, Kusaka M. Yamaoka M, et al. Among authors: kusaka m. J Steroid Biochem Mol Biol. 2012 Apr;129(3-5):115-28. doi: 10.1016/j.jsbmb.2012.01.001. Epub 2012 Jan 12. J Steroid Biochem Mol Biol. 2012. PMID: 22249003

5

Effect of a novel 17,20-lyase inhibitor, orteronel (TAK-700), on androgen synthesis in male rats.

Hara T, Kouno J, Kaku T, Takeuchi T, Kusaka M, Tasaka A, Yamaoka M. Hara T, et al. Among authors: kusaka m. J Steroid Biochem Mol Biol. 2013 Mar;134:80-91. doi: 10.1016/j.jsbmb.2012.10.020. Epub 2012 Nov 9. J Steroid Biochem Mol Biol. 2013. PMID: 23146910

6

C17,20-lyase inhibitors I. Structure-based de novo design and SAR study of C17,20-lyase inhibitors.

Matsunaga N, Kaku T, Itoh F, Tanaka T, Hara T, Miki H, Iwasaki M, Aono T, Yamaoka M, Kusaka M, Tasaka A. Matsunaga N, et al. Among authors: kusaka m. Bioorg Med Chem. 2004 May 1;12(9):2251-73. doi: 10.1016/j.bmc.2004.02.007. Bioorg Med Chem. 2004. PMID: 15080924

7

C(17,20)-lyase inhibitors. Part 2: design, synthesis and structure-activity relationships of (2-naphthylmethyl)-1H-imidazoles as novel C(17,20)-lyase inhibitors.

Matsunaga N, Kaku T, Ojida A, Tanaka T, Hara T, Yamaoka M, Kusaka M, Tasaka A. Matsunaga N, et al. Among authors: kusaka m. Bioorg Med Chem. 2004 Aug 15;12(16):4313-36. doi: 10.1016/j.bmc.2004.06.016. Bioorg Med Chem. 2004. PMID: 15265485

8

Possible role of adaptive mutation in resistance to antiandrogen in prostate cancer cells.

Hara T, Kouno J, Nakamura K, Kusaka M, Yamaoka M. Hara T, et al. Among authors: kusaka m. Prostate. 2005 Nov 1;65(3):268-75. doi: 10.1002/pros.20282. Prostate. 2005. PMID: 16015592

9

17,20-Lyase inhibitors. Part 3: Design, synthesis, and structure-activity relationships of biphenylylmethylimidazole derivatives as novel 17,20-lyase inhibitors.

Kaku T, Tsujimoto S, Matsunaga N, Tanaka T, Hara T, Yamaoka M, Kusaka M, Tasaka A. Kaku T, et al. Among authors: kusaka m. Bioorg Med Chem. 2011 Apr 1;19(7):2428-42. doi: 10.1016/j.bmc.2011.02.009. Epub 2011 Feb 12. Bioorg Med Chem. 2011. PMID: 21429754

10

Discovery of orteronel (TAK-700), a naphthylmethylimidazole derivative, as a highly selective 17,20-lyase inhibitor with potential utility in the treatment of prostate cancer.

Kaku T, Hitaka T, Ojida A, Matsunaga N, Adachi M, Tanaka T, Hara T, Yamaoka M, Kusaka M, Okuda T, Asahi S, Furuya S, Tasaka A. Kaku T, et al. Among authors: kusaka m. Bioorg Med Chem. 2011 Nov 1;19(21):6383-99. doi: 10.1016/j.bmc.2011.08.066. Epub 2011 Sep 1. Bioorg Med Chem. 2011. PMID: 21978946

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