Le TN - Search Results

1

Synthesis, in vitro and in vivo evaluation of 3-arylisoquinolinamines as potent antitumor agents.

Yang SH, Van HT, Le TN, Khadka DB, Cho SH, Lee KT, Chung HJ, Lee SK, Ahn CH, Lee YB, Cho WJ. Yang SH, et al. Among authors: le tn. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5277-81. doi: 10.1016/j.bmcl.2010.06.132. Epub 2010 Jul 3. Bioorg Med Chem Lett. 2010. PMID: 20667733

2

Molecular modeling of 3-arylisoquinoline antitumor agents active against A-549. A comparative molecular field analysis study.

Cho WJ, Kim EK, Park IY, Jeong EY, Kim TS, Le TN, Kim DD, Lee ES. Cho WJ, et al. Among authors: le tn. Bioorg Med Chem. 2002 Sep;10(9):2953-61. doi: 10.1016/s0968-0896(02)00137-2. Bioorg Med Chem. 2002. PMID: 12110317

3

Synthesis of new 3-arylisoquinolinamines: effect on topoisomerase I inhibition and cytotoxicity.

Cho WJ, Min SY, Le TN, Kim TS. Cho WJ, et al. Among authors: le tn. Bioorg Med Chem Lett. 2003 Dec 15;13(24):4451-4. doi: 10.1016/j.bmcl.2003.09.001. Bioorg Med Chem Lett. 2003. PMID: 14643344

4

Convenient synthesis of indeno[1,2-c]isoquinolines as constrained forms of 3-arylisoquinolines and docking study of a topoisomerase I inhibitor into DNA-topoisomerase I complex.

Van HT, Le QM, Lee KY, Lee ES, Kwon Y, Kim TS, Le TN, Lee SH, Cho WJ. Van HT, et al. Among authors: le tn, le qm. Bioorg Med Chem Lett. 2007 Nov 1;17(21):5763-7. doi: 10.1016/j.bmcl.2007.08.062. Epub 2007 Aug 29. Bioorg Med Chem Lett. 2007. PMID: 17827007

5

Development of 3-aryl-1-isoquinolinamines as potent antitumor agents based on CoMFA.

Yang SH, Van HT, Le TN, Khadka DB, Cho SH, Lee KT, Lee ES, Lee YB, Ahn CH, Cho WJ. Yang SH, et al. Among authors: le tn. Eur J Med Chem. 2010 Nov;45(11):5493-7. doi: 10.1016/j.ejmech.2010.08.042. Epub 2010 Aug 24. Eur J Med Chem. 2010. PMID: 20817330

6

Design, synthesis and docking study of 5-amino substituted indeno[1,2-c]isoquinolines as novel topoisomerase I inhibitors.

Khadka DB, Le QM, Yang SH, Van HT, Le TN, Cho SH, Kwon Y, Lee KT, Lee ES, Cho WJ. Khadka DB, et al. Among authors: le tn, le qm. Bioorg Med Chem. 2011 Mar 15;19(6):1924-9. doi: 10.1016/j.bmc.2011.01.064. Epub 2011 Feb 3. Bioorg Med Chem. 2011. PMID: 21353568

7

Design and synthesis of 4-amino-2-phenylquinazolines as novel topoisomerase I inhibitors with molecular modeling.

Le TN, Yang SH, Khadka DB, Van HT, Cho SH, Kwon Y, Lee ES, Lee KT, Cho WJ. Le TN, et al. Bioorg Med Chem. 2011 Jul 15;19(14):4399-404. doi: 10.1016/j.bmc.2011.05.012. Epub 2011 May 20. Bioorg Med Chem. 2011. PMID: 21684168

8

Synthesis of benzo[3,4]azepino[1,2-b]isoquinolin-9-ones from 3-arylisoquinolines via ring closing metathesis and evaluation of topoisomerase I inhibitory activity, cytotoxicity and docking study.

Van HT, Khadka DB, Yang SH, Le TN, Cho SH, Zhao C, Lee IS, Kwon Y, Lee KT, Kim YC, Cho WJ. Van HT, et al. Among authors: le tn. Bioorg Med Chem. 2011 Sep 15;19(18):5311-20. doi: 10.1016/j.bmc.2011.08.006. Epub 2011 Aug 8. Bioorg Med Chem. 2011. PMID: 21873069

9

Modification of 3-arylisoquinolines into 3,4-diarylisoquinolines and assessment of their cytotoxicity and topoisomerase inhibition.

Khadka DB, Woo H, Yang SH, Zhao C, Jin Y, Le TN, Kwon Y, Cho WJ. Khadka DB, et al. Among authors: le tn. Eur J Med Chem. 2015 Mar 6;92:583-607. doi: 10.1016/j.ejmech.2015.01.016. Epub 2015 Jan 14. Eur J Med Chem. 2015. PMID: 25613224

10

Substituted 2-arylquinazolinones: Design, synthesis, and evaluation of cytotoxicity and inhibition of topoisomerases.

Khadka DB, Tran GH, Shin S, Nguyen HT, Cao HT, Zhao C, Jin Y, Van HT, Chau MV, Kwon Y, Le TN, Cho WJ. Khadka DB, et al. Among authors: le tn. Eur J Med Chem. 2015 Oct 20;103:69-79. doi: 10.1016/j.ejmech.2015.08.040. Epub 2015 Aug 28. Eur J Med Chem. 2015. PMID: 26334499

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