Rosen N - Search Results

1

The RAF inhibitor PLX4032 inhibits ERK signaling and tumor cell proliferation in a V600E BRAF-selective manner.

Joseph EW, Pratilas CA, Poulikakos PI, Tadi M, Wang W, Taylor BS, Halilovic E, Persaud Y, Xing F, Viale A, Tsai J, Chapman PB, Bollag G, Solit DB, Rosen N. Joseph EW, et al. Among authors: rosen n. Proc Natl Acad Sci U S A. 2010 Aug 17;107(33):14903-8. doi: 10.1073/pnas.1008990107. Epub 2010 Jul 28. Proc Natl Acad Sci U S A. 2010. PMID: 20668238 Free PMC article.

2

Pharmacologic shifting of a balance between protein refolding and degradation mediated by Hsp90.

Schneider C, Sepp-Lorenzino L, Nimmesgern E, Ouerfelli O, Danishefsky S, Rosen N, Hartl FU. Schneider C, et al. Among authors: rosen n. Proc Natl Acad Sci U S A. 1996 Dec 10;93(25):14536-41. doi: 10.1073/pnas.93.25.14536. Proc Natl Acad Sci U S A. 1996. PMID: 8962087 Free PMC article.

3

Farnesyl transferase inhibitors cause enhanced mitotic sensitivity to taxol and epothilones.

Moasser MM, Sepp-Lorenzino L, Kohl NE, Oliff A, Balog A, Su DS, Danishefsky SJ, Rosen N. Moasser MM, et al. Among authors: rosen n. Proc Natl Acad Sci U S A. 1998 Feb 17;95(4):1369-74. doi: 10.1073/pnas.95.4.1369. Proc Natl Acad Sci U S A. 1998. PMID: 9465021 Free PMC article.

4

Heat shock protein 90 mediates macrophage activation by Taxol and bacterial lipopolysaccharide.

Byrd CA, Bornmann W, Erdjument-Bromage H, Tempst P, Pavletich N, Rosen N, Nathan CF, Ding A. Byrd CA, et al. Among authors: rosen n. Proc Natl Acad Sci U S A. 1999 May 11;96(10):5645-50. doi: 10.1073/pnas.96.10.5645. Proc Natl Acad Sci U S A. 1999. PMID: 10318938 Free PMC article.

5

Modulation of Hsp90 function by ansamycins sensitizes breast cancer cells to chemotherapy-induced apoptosis in an RB- and schedule-dependent manner. See: E. A. Sausville, Combining cytotoxics and 17-allylamino, 17-demethoxygeldanamycin: sequence and tumor biology matters, Clin. Cancer Res., 7: 2155-2158, 2001.

Münster PN, Basso A, Solit D, Norton L, Rosen N. Münster PN, et al. Among authors: rosen n. Clin Cancer Res. 2001 Aug;7(8):2228-36. Clin Cancer Res. 2001. PMID: 11489796

6

Ansamycin antibiotics inhibit Akt activation and cyclin D expression in breast cancer cells that overexpress HER2.

Basso AD, Solit DB, Munster PN, Rosen N. Basso AD, et al. Among authors: rosen n. Oncogene. 2002 Feb 14;21(8):1159-66. doi: 10.1038/sj.onc.1205184. Oncogene. 2002. PMID: 11850835 Free PMC article.

7

17-Allylamino-17-demethoxygeldanamycin induces the degradation of androgen receptor and HER-2/neu and inhibits the growth of prostate cancer xenografts.

Solit DB, Zheng FF, Drobnjak M, Münster PN, Higgins B, Verbel D, Heller G, Tong W, Cordon-Cardo C, Agus DB, Scher HI, Rosen N. Solit DB, et al. Among authors: rosen n. Clin Cancer Res. 2002 May;8(5):986-93. Clin Cancer Res. 2002. PMID: 12006510

8

Akt forms an intracellular complex with heat shock protein 90 (Hsp90) and Cdc37 and is destabilized by inhibitors of Hsp90 function.

Basso AD, Solit DB, Chiosis G, Giri B, Tsichlis P, Rosen N. Basso AD, et al. Among authors: rosen n. J Biol Chem. 2002 Oct 18;277(42):39858-66. doi: 10.1074/jbc.M206322200. Epub 2002 Aug 9. J Biol Chem. 2002. PMID: 12176997 Free article.

9

Total synthesis as a resource in the discovery of potentially valuable antitumor agents: cycloproparadicicol.

Yamamoto K, Garbaccio RM, Stachel SJ, Solit DB, Chiosis G, Rosen N, Danishefsky SJ. Yamamoto K, et al. Among authors: rosen n. Angew Chem Int Ed Engl. 2003 Mar 17;42(11):1280-4. doi: 10.1002/anie.200390329. Angew Chem Int Ed Engl. 2003. PMID: 12645064 No abstract available.

10

Inhibition of heat shock protein 90 function down-regulates Akt kinase and sensitizes tumors to Taxol.

Solit DB, Basso AD, Olshen AB, Scher HI, Rosen N. Solit DB, et al. Among authors: rosen n. Cancer Res. 2003 May 1;63(9):2139-44. Cancer Res. 2003. PMID: 12727831

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