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Estrogen receptor-α directly regulates the hypoxia-inducible factor 1 pathway associated with antiestrogen response in breast cancer.
Yang J, AlTahan A, Jones DT, Buffa FM, Bridges E, Interiano RB, Qu C, Vogt N, Li JL, Baban D, Ragoussis J, Nicholson R, Davidoff AM, Harris AL. Yang J, et al. Proc Natl Acad Sci U S A. 2015 Dec 8;112(49):15172-7. doi: 10.1073/pnas.1422015112. Epub 2015 Nov 23. Proc Natl Acad Sci U S A. 2015. PMID: 26598706 Free PMC article.
Human CHCHD4 mitochondrial proteins regulate cellular oxygen consumption rate and metabolism and provide a critical role in hypoxia signaling and tumor progression.
Yang J, Staples O, Thomas LW, Briston T, Robson M, Poon E, Simões ML, El-Emir E, Buffa FM, Ahmed A, Annear NP, Shukla D, Pedley BR, Maxwell PH, Harris AL, Ashcroft M. Yang J, et al. J Clin Invest. 2012 Feb;122(2):600-11. doi: 10.1172/JCI58780. Epub 2012 Jan 3. J Clin Invest. 2012. PMID: 22214851 Free PMC article.
The role of histone demethylase KDM4B in Myc signaling in neuroblastoma.
Yang J, AlTahan AM, Hu D, Wang Y, Cheng PH, Morton CL, Qu C, Nathwani AC, Shohet JM, Fotsis T, Koster J, Versteeg R, Okada H, Harris AL, Davidoff AM. Yang J, et al. J Natl Cancer Inst. 2015 Apr 29;107(6):djv080. doi: 10.1093/jnci/djv080. Print 2015 Jun. J Natl Cancer Inst. 2015. PMID: 25925418 Free PMC article.
Targeting Histone Demethylases in MYC-Driven Neuroblastomas with Ciclopirox.
Yang J, Milasta S, Hu D, AlTahan AM, Interiano RB, Zhou J, Davidson J, Low J, Lin W, Bao J, Goh P, Nathwani AC, Wang R, Wang Y, Ong SS, Boyd VA, Young B, Das S, Shelat A, Wu Y, Li Z, Zheng JJ, Mishra A, Cheng Y, Qu C, Peng J, Green DR, White S, Guy RK, Chen T, Davidoff AM. Yang J, et al. Cancer Res. 2017 Sep 1;77(17):4626-4638. doi: 10.1158/0008-5472.CAN-16-0826. Epub 2017 Jul 6. Cancer Res. 2017. PMID: 28684529 Free PMC article.
Small-molecule activation of p53 blocks hypoxia-inducible factor 1alpha and vascular endothelial growth factor expression in vivo and leads to tumor cell apoptosis in normoxia and hypoxia.
Yang J, Ahmed A, Poon E, Perusinghe N, de Haven Brandon A, Box G, Valenti M, Eccles S, Rouschop K, Wouters B, Ashcroft M. Yang J, et al. Mol Cell Biol. 2009 Apr;29(8):2243-53. doi: 10.1128/MCB.00959-08. Epub 2009 Feb 17. Mol Cell Biol. 2009. PMID: 19223463 Free PMC article.
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