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Synthesis, biological evaluation and molecular modelling studies of methyleneimidazole substituted biaryls as inhibitors of human 17alpha-hydroxylase-17,20-lyase (CYP17). Part I: Heterocyclic modifications of the core structure.
Jagusch C, Negri M, Hille UE, Hu Q, Bartels M, Jahn-Hoffmann K, Pinto-Bazurco Mendieta MA, Rodenwaldt B, Müller-Vieira U, Schmidt D, Lauterbach T, Recanatini M, Cavalli A, Hartmann RW. Jagusch C, et al. Among authors: hu q. Bioorg Med Chem. 2008 Feb 15;16(4):1992-2010. doi: 10.1016/j.bmc.2007.10.094. Epub 2007 Nov 4. Bioorg Med Chem. 2008. PMID: 18061460
Synthesis, biological evaluation, and molecular modeling studies of methylene imidazole substituted biaryls as inhibitors of human 17alpha-hydroxylase-17,20-lyase (CYP17)--part II: Core rigidification and influence of substituents at the methylene bridge.
Hu Q, Negri M, Jahn-Hoffmann K, Zhuang Y, Olgen S, Bartels M, Müller-Vieira U, Lauterbach T, Hartmann RW. Hu Q, et al. Bioorg Med Chem. 2008 Aug 15;16(16):7715-27. doi: 10.1016/j.bmc.2008.07.011. Epub 2008 Jul 9. Bioorg Med Chem. 2008. PMID: 18674917
CYP17 inhibitors. Annulations of additional rings in methylene imidazole substituted biphenyls: synthesis, biological evaluation and molecular modelling.
Pinto-Bazurco Mendieta MA, Negri M, Hu Q, Hille UE, Jagusch C, Jahn-Hoffmann K, Müller-Vieira U, Schmidt D, Lauterbach T, Hartmann RW. Pinto-Bazurco Mendieta MA, et al. Among authors: hu q. Arch Pharm (Weinheim). 2008 Oct;341(10):597-609. doi: 10.1002/ardp.200700251. Arch Pharm (Weinheim). 2008. PMID: 18720339
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