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Structural basis for a new mechanism of inhibition of HIV-1 integrase identified by fragment screening and structure-based design.
Rhodes DI, Peat TS, Vandegraaff N, Jeevarajah D, Le G, Jones ED, Smith JA, Coates JA, Winfield LJ, Thienthong N, Newman J, Lucent D, Ryan JH, Savage GP, Francis CL, Deadman JJ. Rhodes DI, et al. Among authors: deadman jj. Antivir Chem Chemother. 2011 Mar 7;21(4):155-68. doi: 10.3851/IMP1716. Antivir Chem Chemother. 2011. PMID: 21602613 Free article.
Small molecule inhibitors of the LEDGF site of human immunodeficiency virus integrase identified by fragment screening and structure based design.
Peat TS, Rhodes DI, Vandegraaff N, Le G, Smith JA, Clark LJ, Jones ED, Coates JA, Thienthong N, Newman J, Dolezal O, Mulder R, Ryan JH, Savage GP, Francis CL, Deadman JJ. Peat TS, et al. Among authors: deadman jj. PLoS One. 2012;7(7):e40147. doi: 10.1371/journal.pone.0040147. Epub 2012 Jul 10. PLoS One. 2012. PMID: 22808106 Free PMC article.
Studies on the structure-activity relationship of 1,3,3,4-tetra-substituted pyrrolidine embodied CCR5 receptor antagonists. Part 1: Tuning the N-substituents.
Ben L, Jones ED, Zhou E, Li C, Baylis DC, Yu S, Wang M, He X, Coates JA, Rhodes DI, Pei G, Deadman JJ, Xie X, Ma D. Ben L, et al. Among authors: deadman jj. Bioorg Med Chem Lett. 2010 Jul 15;20(14):4012-4. doi: 10.1016/j.bmcl.2010.05.102. Epub 2010 Jun 1. Bioorg Med Chem Lett. 2010. PMID: 20561788
Studies on the structure-activity relationship of 1,3,3,4-tetra-substituted pyrrolidine embodied CCR5 receptor antagonists. Part 2: Discovery of highly potent anti-HIV agents.
Li B, Jones ED, Zhou E, Chen L, Baylis DC, Yu S, Wang M, He X, Coates JA, Rhodes DI, Pei G, Deadman JJ, Xie X, Ma D. Li B, et al. Among authors: deadman jj. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5334-6. doi: 10.1016/j.bmcl.2010.05.046. Epub 2010 May 19. Bioorg Med Chem Lett. 2010. PMID: 20674358
40 results