Hoyt D - Search Results

1

A novel small molecule inhibits STAT3 phosphorylation and DNA binding activity and exhibits potent growth suppressive activity in human cancer cells.

Lin L, Deangelis S, Foust E, Fuchs J, Li C, Li PK, Schwartz EB, Lesinski GB, Benson D, Lü J, Hoyt D, Lin J. Lin L, et al. Among authors: hoyt d. Mol Cancer. 2010 Aug 16;9:217. doi: 10.1186/1476-4598-9-217. Mol Cancer. 2010. PMID: 20712901 Free PMC article.

2

The small molecule curcumin analog FLLL32 induces apoptosis in melanoma cells via STAT3 inhibition and retains the cellular response to cytokines with anti-tumor activity.

Bill MA, Fuchs JR, Li C, Yui J, Bakan C, Benson DM Jr, Schwartz EB, Abdelhamid D, Lin J, Hoyt DG, Fossey SL, Young GS, Carson WE 3rd, Li PK, Lesinski GB. Bill MA, et al. Among authors: hoyt dg. Mol Cancer. 2010 Jun 25;9:165. doi: 10.1186/1476-4598-9-165. Mol Cancer. 2010. PMID: 20576164 Free PMC article.

3

p38 Mitogen-activated protein kinase mediates synergistic induction of inducible nitric-oxide synthase by lipopolysaccharide and interferon-gamma through signal transducer and activator of transcription 1 Ser727 phosphorylation in murine aortic endothelial cells.

Huang H, Rose JL, Hoyt DG. Huang H, et al. Mol Pharmacol. 2004 Aug;66(2):302-11. doi: 10.1124/mol.66.2.302. Mol Pharmacol. 2004. PMID: 15266021

4

Integrin-mediated suppression of endotoxin-induced DNA damage in lung endothelial cells is sensitive to poly(ADP-ribose) polymerase-1 gene deletion.

Huang H, McIntosh JL, Fang L, Szabo C, Hoyt DG. Huang H, et al. Int J Mol Med. 2003 Oct;12(4):533-40. Int J Mol Med. 2003. PMID: 12964031

5

Regulation of bleomycin-induced DNA breakage and chromatin structure in lung endothelial cells by integrins and poly(ADP-ribose) polymerase.

Jones CB, McIntosh J, Huang H, Graytock A, Hoyt DG. Jones CB, et al. Among authors: hoyt dg. Mol Pharmacol. 2001 Jan;59(1):69-75. doi: 10.1124/mol.59.1.69. Mol Pharmacol. 2001. PMID: 11125026

6

Cellular uptake and intracellular levels of the bcl-2 antisense g3139 in cultured cells and treated patients with acute myeloid leukemia.

Dai G, Chan KK, Liu S, Hoyt D, Whitman S, Klisovic M, Shen T, Caligiuri MA, Byrd J, Grever M, Marcucci G. Dai G, et al. Among authors: hoyt d. Clin Cancer Res. 2005 Apr 15;11(8):2998-3008. doi: 10.1158/1078-0432.CCR-04-1505. Clin Cancer Res. 2005. PMID: 15837754

7

Integrin engagement increases histone H3 acetylation and reduces histone H1 association with DNA in murine lung endothelial cells.

Rose JL, Huang H, Wray SF, Hoyt DG. Rose JL, et al. Mol Pharmacol. 2005 Aug;68(2):439-46. doi: 10.1124/mol.104.010876. Epub 2005 May 18. Mol Pharmacol. 2005. PMID: 15901851

8

Base excision repair proteins are required for integrin-mediated suppression of bleomycin-induced DNA breakage in murine lung endothelial cells.

Rose JL, Reeves KC, Likhotvorik RI, Hoyt DG. Rose JL, et al. J Pharmacol Exp Ther. 2007 Apr;321(1):318-26. doi: 10.1124/jpet.106.113498. Epub 2007 Jan 3. J Pharmacol Exp Ther. 2007. PMID: 17202402

9

Sensitivity of mice to lipopolysaccharide is increased by a high saturated fat and cholesterol diet.

Huang H, Liu T, Rose JL, Stevens RL, Hoyt DG. Huang H, et al. J Inflamm (Lond). 2007 Nov 12;4:22. doi: 10.1186/1476-9255-4-22. J Inflamm (Lond). 2007. PMID: 17997851 Free PMC article.

10

Protein Never in Mitosis Gene A Interacting-1 regulates calpain activity and the degradation of cyclooxygenase-2 in endothelial cells.

Liu T, Schneider RA, Shah V, Huang Y, Likhotvorik RI, Keshvara L, Hoyt DG. Liu T, et al. J Inflamm (Lond). 2009 Jun 22;6:20. doi: 10.1186/1476-9255-6-20. J Inflamm (Lond). 2009. PMID: 19545424 Free PMC article.

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