Lavelle D - Search Results

1

Decitabine increases fetal hemoglobin in Papio anubis by increasing γ-globin gene transcription.

Akpan I, Banzon V, Ibanez V, Vaitkus K, DeSimone J, Lavelle D. Akpan I, et al. Among authors: lavelle d. Exp Hematol. 2010 Nov;38(11):989-993.e1. doi: 10.1016/j.exphem.2010.08.001. Epub 2010 Aug 14. Exp Hematol. 2010. PMID: 20713129 Free PMC article.

2

Developmental changes in DNA methylation and covalent histone modifications of chromatin associated with the epsilon-, gamma-, and beta-globin gene promoters in Papio anubis.

Lavelle D, Vaitkus K, Hankewych M, Singh M, DeSimone J. Lavelle D, et al. Blood Cells Mol Dis. 2006 Mar-Apr;36(2):269-78. doi: 10.1016/j.bcmd.2006.01.004. Epub 2006 Mar 9. Blood Cells Mol Dis. 2006. PMID: 16527500

3

Effect of 5-aza-2'-deoxycytidine (Dacogen) on covalent histone modifications of chromatin associated with the epsilon-, gamma-, and beta-globin promoters in Papio anubis.

Lavelle D, Vaitkus K, Hankewych M, Singh M, DeSimone J. Lavelle D, et al. Exp Hematol. 2006 Mar;34(3):339-47. doi: 10.1016/j.exphem.2005.12.010. Exp Hematol. 2006. PMID: 16543068 Free article.

4

The gamma-globin gene promoter progressively demethylates as the hematopoietic stem progenitor cells differentiate along the erythroid lineage in baboon fetal liver and adult bone marrow.

Singh M, Lavelle D, Vaitkus K, Mahmud N, Hankewych M, DeSimone J. Singh M, et al. Among authors: lavelle d. Exp Hematol. 2007 Jan;35(1):48-55. doi: 10.1016/j.exphem.2006.09.001. Exp Hematol. 2007. PMID: 17198873 Free article.

5

Oral decitabine reactivates expression of the methylated gamma-globin gene in Papio anubis.

Lavelle D, Chin J, Vaitkus K, Redkar S, Phiasivongsa P, Tang C, Will R, Hankewych M, Roxas B, Singh M, Saunthararajah Y, Desimone J. Lavelle D, et al. Am J Hematol. 2007 Nov;82(11):981-5. doi: 10.1002/ajh.21020. Am J Hematol. 2007. PMID: 17696208 Free article.

6

Transcriptional activation of the gamma-globin gene in baboons treated with decitabine and in cultured erythroid progenitor cells involves different mechanisms.

Chin J, Singh M, Banzon V, Vaitkus K, Ibanez V, Kouznetsova T, Mahmud N, DeSimone J, Lavelle D. Chin J, et al. Among authors: lavelle d. Exp Hematol. 2009 Oct;37(10):1131-42. doi: 10.1016/j.exphem.2009.06.007. Epub 2009 Jul 2. Exp Hematol. 2009. PMID: 19576949 Free PMC article.

7

S110, a novel decitabine dinucleotide, increases fetal hemoglobin levels in baboons (P. anubis).

Lavelle D, Saunthararajah Y, Vaitkus K, Singh M, Banzon V, Phiasivongsva P, Redkar S, Kanekal S, Bearss D, Shi C, Inloes R, DeSimone J. Lavelle D, et al. J Transl Med. 2010 Oct 8;8:92. doi: 10.1186/1479-5876-8-92. J Transl Med. 2010. PMID: 20932295 Free PMC article.

8

siDNMT1 increases γ-globin expression in chemical inducer of dimerization (CID)-dependent mouse βYAC bone marrow cells and in baboon erythroid progenitor cell cultures.

Banzon V, Ibanez V, Vaitkus K, Ruiz MA, Peterson K, DeSimone J, Lavelle D. Banzon V, et al. Among authors: lavelle d. Exp Hematol. 2011 Jan;39(1):26-36.e1. doi: 10.1016/j.exphem.2010.10.003. Epub 2010 Oct 23. Exp Hematol. 2011. PMID: 20974210 Free PMC article.

9

Effects of tetrahydrouridine on pharmacokinetics and pharmacodynamics of oral decitabine.

Lavelle D, Vaitkus K, Ling Y, Ruiz MA, Mahfouz R, Ng KP, Negrotto S, Smith N, Terse P, Engelke KJ, Covey J, Chan KK, Desimone J, Saunthararajah Y. Lavelle D, et al. Blood. 2012 Feb 2;119(5):1240-7. doi: 10.1182/blood-2011-08-371690. Epub 2011 Dec 7. Blood. 2012. PMID: 22160381 Free PMC article.

10

RN-1, a potent and selective lysine-specific demethylase 1 inhibitor, increases γ-globin expression, F reticulocytes, and F cells in a sickle cell disease mouse model.

Rivers A, Vaitkus K, Ruiz MA, Ibanez V, Jagadeeswaran R, Kouznetsova T, DeSimone J, Lavelle D. Rivers A, et al. Among authors: lavelle d. Exp Hematol. 2015 Jul;43(7):546-53.e1-3. doi: 10.1016/j.exphem.2015.04.005. Epub 2015 Apr 27. Exp Hematol. 2015. PMID: 25931013 Free PMC article.

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