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Activin-like kinase 5 (ALK5) mediates abnormal proliferation of vascular smooth muscle cells from patients with familial pulmonary arterial hypertension and is involved in the progression of experimental pulmonary arterial hypertension induced by monocrotaline.
Thomas M, Docx C, Holmes AM, Beach S, Duggan N, England K, Leblanc C, Lebret C, Schindler F, Raza F, Walker C, Crosby A, Davies RJ, Morrell NW, Budd DC. Thomas M, et al. Among authors: holmes am. Am J Pathol. 2009 Feb;174(2):380-9. doi: 10.2353/ajpath.2009.080565. Epub 2008 Dec 30. Am J Pathol. 2009. PMID: 19116361 Free PMC article.
A novel murine model of severe pulmonary arterial hypertension.
Ciuclan L, Bonneau O, Hussey M, Duggan N, Holmes AM, Good R, Stringer R, Jones P, Morrell NW, Jarai G, Walker C, Westwick J, Thomas M. Ciuclan L, et al. Among authors: holmes am. Am J Respir Crit Care Med. 2011 Nov 15;184(10):1171-82. doi: 10.1164/rccm.201103-0412OC. Epub 2011 Aug 25. Am J Respir Crit Care Med. 2011. PMID: 21868504
BMP type II receptor deficiency confers resistance to growth inhibition by TGF-β in pulmonary artery smooth muscle cells: role of proinflammatory cytokines.
Davies RJ, Holmes AM, Deighton J, Long L, Yang X, Barker L, Walker C, Budd DC, Upton PD, Morrell NW. Davies RJ, et al. Among authors: holmes am. Am J Physiol Lung Cell Mol Physiol. 2012 Mar 15;302(6):L604-15. doi: 10.1152/ajplung.00309.2011. Epub 2012 Jan 6. Am J Physiol Lung Cell Mol Physiol. 2012. PMID: 22227206 Free PMC article.
Assessment of Brd4 inhibition in idiopathic pulmonary fibrosis lung fibroblasts and in vivo models of lung fibrosis.
Tang X, Peng R, Phillips JE, Deguzman J, Ren Y, Apparsundaram S, Luo Q, Bauer CM, Fuentes ME, DeMartino JA, Tyagi G, Garrido R, Hogaboam CM, Denton CP, Holmes AM, Kitson C, Stevenson CS, Budd DC. Tang X, et al. Among authors: holmes am. Am J Pathol. 2013 Aug;183(2):470-9. doi: 10.1016/j.ajpath.2013.04.020. Epub 2013 Jun 10. Am J Pathol. 2013. PMID: 23759512 Free article.
179 results