Marek G - Search Results

1

Effects of a positive allosteric modulator of group II metabotropic glutamate receptors, LY487379, on cognitive flexibility and impulsive-like responding in rats.

Nikiforuk A, Popik P, Drescher KU, van Gaalen M, Relo AL, Mezler M, Marek G, Schoemaker H, Gross G, Bespalov A. Nikiforuk A, et al. Among authors: marek g. J Pharmacol Exp Ther. 2010 Dec;335(3):665-73. doi: 10.1124/jpet.110.170506. Epub 2010 Aug 25. J Pharmacol Exp Ther. 2010. PMID: 20739457

2

Glutamatergic (N-methyl-D-aspartate receptor) hypofrontality in schizophrenia: too little juice or a miswired brain?

Marek GJ, Behl B, Bespalov AY, Gross G, Lee Y, Schoemaker H. Marek GJ, et al. Mol Pharmacol. 2010 Mar;77(3):317-26. doi: 10.1124/mol.109.059865. Epub 2009 Nov 23. Mol Pharmacol. 2010. PMID: 19933774 Review.

3

LY-2140023, a prodrug of the group II metabotropic glutamate receptor agonist LY-404039 for the potential treatment of schizophrenia.

Mezler M, Geneste H, Gault L, Marek GJ. Mezler M, et al. Curr Opin Investig Drugs. 2010 Jul;11(7):833-45. Curr Opin Investig Drugs. 2010. PMID: 20571979 Clinical Trial.

4

Awake rat pharmacological magnetic resonance imaging as a translational pharmacodynamic biomarker: metabotropic glutamate 2/3 agonist modulation of ketamine-induced blood oxygenation level dependence signals.

Chin CL, Upadhyay J, Marek GJ, Baker SJ, Zhang M, Mezler M, Fox GB, Day M. Chin CL, et al. J Pharmacol Exp Ther. 2011 Mar;336(3):709-15. doi: 10.1124/jpet.110.173880. Epub 2010 Dec 20. J Pharmacol Exp Ther. 2011. PMID: 21172908

5

Heterocomplex formation of 5-HT2A-mGlu2 and its relevance for cellular signaling cascades.

Delille HK, Becker JM, Burkhardt S, Bleher B, Terstappen GC, Schmidt M, Meyer AH, Unger L, Marek GJ, Mezler M. Delille HK, et al. Neuropharmacology. 2012 Jun;62(7):2184-91. doi: 10.1016/j.neuropharm.2012.01.010. Epub 2012 Jan 25. Neuropharmacology. 2012. PMID: 22300836

6

Activation of adenosine₁ receptors induces antidepressant-like, anti-impulsive effects on differential reinforcement of low-rate 72-s behavior in rats.

Marek GJ. Marek GJ. J Pharmacol Exp Ther. 2012 May;341(2):564-70. doi: 10.1124/jpet.112.191718. Epub 2012 Feb 8. J Pharmacol Exp Ther. 2012. PMID: 22323824 Free PMC article.

7

The two faces of the pharmacological interaction of mGlu2 and 5-HT₂A - relevance of receptor heterocomplexes and interaction through functional brain pathways.

Delille HK, Mezler M, Marek GJ. Delille HK, et al. Neuropharmacology. 2013 Jul;70:296-305. doi: 10.1016/j.neuropharm.2013.02.005. Epub 2013 Mar 4. Neuropharmacology. 2013. PMID: 23466331 Review.

8

Physiological antagonism between 5-hydroxytryptamine(2A) and group II metabotropic glutamate receptors in prefrontal cortex.

Marek GJ, Wright RA, Schoepp DD, Monn JA, Aghajanian GK. Marek GJ, et al. J Pharmacol Exp Ther. 2000 Jan;292(1):76-87. J Pharmacol Exp Ther. 2000. PMID: 10604933

9

N-(4-((2-(trifluoromethyl)-3-hydroxy-4-(isobutyryl)phenoxy)methyl)benzyl)-1-methyl-1H-imidazole-4-carboxamide (THIIC), a novel metabotropic glutamate 2 potentiator with potential anxiolytic/antidepressant properties: in vivo profiling suggests a link between behavioral and central nervous system neurochemical changes.

Fell MJ, Witkin JM, Falcone JF, Katner JS, Perry KW, Hart J, Rorick-Kehn L, Overshiner CD, Rasmussen K, Chaney SF, Benvenga MJ, Li X, Marlow DL, Thompson LK, Luecke SK, Wafford KA, Seidel WF, Edgar DM, Quets AT, Felder CC, Wang X, Heinz BA, Nikolayev A, Kuo MS, Mayhugh D, Khilevich A, Zhang D, Ebert PJ, Eckstein JA, Ackermann BL, Swanson SP, Catlow JT, Dean RA, Jackson K, Tauscher-Wisniewski S, Marek GJ, Schkeryantz JM, Svensson KA. Fell MJ, et al. J Pharmacol Exp Ther. 2011 Jan;336(1):165-77. doi: 10.1124/jpet.110.172957. Epub 2010 Oct 14. J Pharmacol Exp Ther. 2011. PMID: 20947638

10

Pharmacological and pharmacokinetic properties of a structurally novel, potent, and selective metabotropic glutamate 2/3 receptor agonist: in vitro characterization of agonist (-)-(1R,4S,5S,6S)-4-amino-2-sulfonylbicyclo[3.1.0]-hexane-4,6-dicarboxylic acid (LY404039).

Rorick-Kehn LM, Johnson BG, Burkey JL, Wright RA, Calligaro DO, Marek GJ, Nisenbaum ES, Catlow JT, Kingston AE, Giera DD, Herin MF, Monn JA, McKinzie DL, Schoepp DD. Rorick-Kehn LM, et al. Among authors: marek gj. J Pharmacol Exp Ther. 2007 Apr;321(1):308-17. doi: 10.1124/jpet.106.110809. Epub 2007 Jan 4. J Pharmacol Exp Ther. 2007. PMID: 17204749

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