Leonardi R - Search Results

1

Modulation of pantothenate kinase 3 activity by small molecules that interact with the substrate/allosteric regulatory domain.

Leonardi R, Zhang YM, Yun MK, Zhou R, Zeng FY, Lin W, Cui J, Chen T, Rock CO, White SW, Jackowski S. Leonardi R, et al. Chem Biol. 2010 Aug 27;17(8):892-902. doi: 10.1016/j.chembiol.2010.06.006. Chem Biol. 2010. PMID: 20797618 Free PMC article.

2

A pantothenate kinase from Staphylococcus aureus refractory to feedback regulation by coenzyme A.

Leonardi R, Chohnan S, Zhang YM, Virga KG, Lee RE, Rock CO, Jackowski S. Leonardi R, et al. J Biol Chem. 2005 Feb 4;280(5):3314-22. doi: 10.1074/jbc.M411608200. Epub 2004 Nov 17. J Biol Chem. 2005. PMID: 15548531 Free article.

3

Structure-activity relationships and enzyme inhibition of pantothenamide-type pantothenate kinase inhibitors.

Virga KG, Zhang YM, Leonardi R, Ivey RA, Hevener K, Park HW, Jackowski S, Rock CO, Lee RE. Virga KG, et al. Among authors: leonardi r. Bioorg Med Chem. 2006 Feb 15;14(4):1007-20. doi: 10.1016/j.bmc.2005.09.021. Epub 2005 Oct 5. Bioorg Med Chem. 2006. PMID: 16213731

4

Activation of human mitochondrial pantothenate kinase 2 by palmitoylcarnitine.

Leonardi R, Rock CO, Jackowski S, Zhang YM. Leonardi R, et al. Proc Natl Acad Sci U S A. 2007 Jan 30;104(5):1494-9. doi: 10.1073/pnas.0607621104. Epub 2007 Jan 22. Proc Natl Acad Sci U S A. 2007. PMID: 17242360 Free PMC article.

5

Localization and regulation of mouse pantothenate kinase 2.

Leonardi R, Zhang YM, Lykidis A, Rock CO, Jackowski S. Leonardi R, et al. FEBS Lett. 2007 Oct 2;581(24):4639-44. doi: 10.1016/j.febslet.2007.08.056. Epub 2007 Sep 7. FEBS Lett. 2007. PMID: 17825826 Free PMC article.

6

Pantothenate kinase 1 is required to support the metabolic transition from the fed to the fasted state.

Leonardi R, Rehg JE, Rock CO, Jackowski S. Leonardi R, et al. PLoS One. 2010 Jun 14;5(6):e11107. doi: 10.1371/journal.pone.0011107. PLoS One. 2010. PMID: 20559429 Free PMC article.

7

Cancer-associated isocitrate dehydrogenase mutations inactivate NADPH-dependent reductive carboxylation.

Leonardi R, Subramanian C, Jackowski S, Rock CO. Leonardi R, et al. J Biol Chem. 2012 Apr 27;287(18):14615-20. doi: 10.1074/jbc.C112.353946. Epub 2012 Mar 22. J Biol Chem. 2012. PMID: 22442146 Free PMC article.

8

Pank1 deletion in leptin-deficient mice reduces hyperglycaemia and hyperinsulinaemia and modifies global metabolism without affecting insulin resistance.

Leonardi R, Rock CO, Jackowski S. Leonardi R, et al. Diabetologia. 2014 Jul;57(7):1466-75. doi: 10.1007/s00125-014-3245-5. Epub 2014 Apr 30. Diabetologia. 2014. PMID: 24781151 Free PMC article.

9

A high-throughput screen reveals new small-molecule activators and inhibitors of pantothenate kinases.

Sharma LK, Leonardi R, Lin W, Boyd VA, Goktug A, Shelat AA, Chen T, Jackowski S, Rock CO. Sharma LK, et al. Among authors: leonardi r. J Med Chem. 2015 Feb 12;58(3):1563-8. doi: 10.1021/jm501585q. Epub 2015 Jan 21. J Med Chem. 2015. PMID: 25569308 Free PMC article.

10

Coenzyme A: back in action.

Leonardi R, Zhang YM, Rock CO, Jackowski S. Leonardi R, et al. Prog Lipid Res. 2005 Mar-May;44(2-3):125-53. doi: 10.1016/j.plipres.2005.04.001. Epub 2005 Apr 20. Prog Lipid Res. 2005. PMID: 15893380 Review.

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