Deflorian F - Search Results

1

Synthesis and evaluation of 1,2,4-triazolo[1,5-c]pyrimidine derivatives as A2A receptor-selective antagonists.

Shinkre BA, Kumar TS, Gao ZG, Deflorian F, Jacobson KA, Trenkle WC. Shinkre BA, et al. Among authors: deflorian f. Bioorg Med Chem Lett. 2010 Oct 1;20(19):5690-4. doi: 10.1016/j.bmcl.2010.08.021. Epub 2010 Aug 10. Bioorg Med Chem Lett. 2010. PMID: 20801028 Free PMC article.

2

Molecular probes for the A2A adenosine receptor based on a pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine scaffold.

Kumar TS, Mishra S, Deflorian F, Yoo LS, Phan K, Kecskés M, Szabo A, Shinkre B, Gao ZG, Trenkle W, Jacobson KA. Kumar TS, et al. Among authors: deflorian f. Bioorg Med Chem Lett. 2011 May 1;21(9):2740-5. doi: 10.1016/j.bmcl.2010.11.082. Epub 2010 Nov 21. Bioorg Med Chem Lett. 2011. PMID: 21185184 Free PMC article.

3

Evaluation of molecular modeling of agonist binding in light of the crystallographic structure of an agonist-bound A₂A adenosine receptor.

Deflorian F, Kumar TS, Phan K, Gao ZG, Xu F, Wu H, Katritch V, Stevens RC, Jacobson KA. Deflorian F, et al. J Med Chem. 2012 Jan 12;55(1):538-52. doi: 10.1021/jm201461q. Epub 2011 Dec 12. J Med Chem. 2012. PMID: 22104008 Free PMC article.

4

Optimization of adenosine 5'-carboxamide derivatives as adenosine receptor agonists using structure-based ligand design and fragment screening.

Tosh DK, Phan K, Gao ZG, Gakh AA, Xu F, Deflorian F, Abagyan R, Stevens RC, Jacobson KA, Katritch V. Tosh DK, et al. Among authors: deflorian f. J Med Chem. 2012 May 10;55(9):4297-308. doi: 10.1021/jm300095s. Epub 2012 Apr 30. J Med Chem. 2012. PMID: 22486652 Free PMC article.

5

Structure-guided design of A(3) adenosine receptor-selective nucleosides: combination of 2-arylethynyl and bicyclo[3.1.0]hexane substitutions.

Tosh DK, Deflorian F, Phan K, Gao ZG, Wan TC, Gizewski E, Auchampach JA, Jacobson KA. Tosh DK, et al. Among authors: deflorian f. J Med Chem. 2012 May 24;55(10):4847-60. doi: 10.1021/jm300396n. Epub 2012 May 16. J Med Chem. 2012. PMID: 22559880 Free PMC article.

6

Structural sweet spot for A1 adenosine receptor activation by truncated (N)-methanocarba nucleosides: receptor docking and potent anticonvulsant activity.

Tosh DK, Paoletta S, Deflorian F, Phan K, Moss SM, Gao ZG, Jiang X, Jacobson KA. Tosh DK, et al. Among authors: deflorian f. J Med Chem. 2012 Sep 27;55(18):8075-90. doi: 10.1021/jm300965a. Epub 2012 Sep 10. J Med Chem. 2012. PMID: 22921089 Free PMC article.

7

Comparison of three GPCR structural templates for modeling of the P2Y12 nucleotide receptor.

Deflorian F, Jacobson KA. Deflorian F, et al. J Comput Aided Mol Des. 2011 Apr;25(4):329-38. doi: 10.1007/s10822-011-9423-3. Epub 2011 Apr 3. J Comput Aided Mol Des. 2011. PMID: 21461952 Free PMC article.

8

Pharmacochemistry of the platelet purinergic receptors.

Jacobson KA, Deflorian F, Mishra S, Costanzi S. Jacobson KA, et al. Among authors: deflorian f. Purinergic Signal. 2011 Sep;7(3):305-24. doi: 10.1007/s11302-011-9216-0. Epub 2011 Feb 18. Purinergic Signal. 2011. PMID: 21484092 Free PMC article.

9

Truncated (N)-Methanocarba Nucleosides as A(1) Adenosine Receptor Agonists and Partial Agonists: Overcoming Lack of a Recognition Element.

Tosh DK, Phan K, Deflorian F, Wei Q, Gao ZG, Jacobson KA. Tosh DK, et al. Among authors: deflorian f. ACS Med Chem Lett. 2011 Aug 11;2(8):626-631. doi: 10.1021/ml200114q. ACS Med Chem Lett. 2011. PMID: 21858244 Free PMC article.

10

Click modification in the N6 region of A3 adenosine receptor-selective carbocyclic nucleosides for dendrimeric tethering that preserves pharmacophore recognition.

Tosh DK, Phan K, Deflorian F, Wei Q, Yoo LS, Gao ZG, Jacobson KA. Tosh DK, et al. Among authors: deflorian f. Bioconjug Chem. 2012 Feb 15;23(2):232-47. doi: 10.1021/bc200526c. Epub 2012 Jan 11. Bioconjug Chem. 2012. PMID: 22175234 Free PMC article.

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