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Modification of cysteine 179 of IkappaBalpha kinase by nimbolide leads to down-regulation of NF-kappaB-regulated cell survival and proliferative proteins and sensitization of tumor cells to chemotherapeutic agents.
Gupta SC, Prasad S, Reuter S, Kannappan R, Yadav VR, Ravindran J, Hema PS, Chaturvedi MM, Nair M, Aggarwal BB. Gupta SC, et al. Among authors: aggarwal bb. J Biol Chem. 2010 Nov 12;285(46):35406-17. doi: 10.1074/jbc.M110.161984. Epub 2010 Sep 9. J Biol Chem. 2010. PMID: 20829362 Free PMC article.
NF-kappaB and cancer: how intimate is this relationship.
Prasad S, Ravindran J, Aggarwal BB. Prasad S, et al. Among authors: aggarwal bb. Mol Cell Biochem. 2010 Mar;336(1-2):25-37. doi: 10.1007/s11010-009-0267-2. Epub 2009 Oct 8. Mol Cell Biochem. 2010. PMID: 19823771 Free PMC article. Review.
Celastrol, a triterpene, enhances TRAIL-induced apoptosis through the down-regulation of cell survival proteins and up-regulation of death receptors.
Sung B, Park B, Yadav VR, Aggarwal BB. Sung B, et al. Among authors: aggarwal bb. J Biol Chem. 2010 Apr 9;285(15):11498-507. doi: 10.1074/jbc.M109.090209. Epub 2010 Feb 12. J Biol Chem. 2010. Retraction in: J Biol Chem. 2016 Aug 5;291(32):16920. doi: 10.1074/jbc.A109.090209 PMID: 20154087 Free PMC article. Retracted.
Inhibiting NF-κB activation by small molecules as a therapeutic strategy.
Gupta SC, Sundaram C, Reuter S, Aggarwal BB. Gupta SC, et al. Among authors: aggarwal bb. Biochim Biophys Acta. 2010 Oct-Dec;1799(10-12):775-87. doi: 10.1016/j.bbagrm.2010.05.004. Epub 2010 May 21. Biochim Biophys Acta. 2010. PMID: 20493977 Free PMC article. Review.
Crotepoxide chemosensitizes tumor cells through inhibition of expression of proliferation, invasion, and angiogenic proteins linked to proinflammatory pathway.
Prasad S, Yadav VR, Sundaram C, Reuter S, Hema PS, Nair MS, Chaturvedi MM, Aggarwal BB. Prasad S, et al. Among authors: aggarwal bb. J Biol Chem. 2010 Aug 27;285(35):26987-27000. doi: 10.1074/jbc.M110.121061. Epub 2010 Jun 23. J Biol Chem. 2010. Retraction in: J Biol Chem. 2016 Aug 5;291(32):16921. doi: 10.1074/jbc.A110.121061 PMID: 20576605 Free PMC article. Retracted.
Cyclodextrin-complexed curcumin exhibits anti-inflammatory and antiproliferative activities superior to those of curcumin through higher cellular uptake.
Yadav VR, Prasad S, Kannappan R, Ravindran J, Chaturvedi MM, Vaahtera L, Parkkinen J, Aggarwal BB. Yadav VR, et al. Among authors: aggarwal bb. Biochem Pharmacol. 2010 Oct 1;80(7):1021-32. doi: 10.1016/j.bcp.2010.06.022. Epub 2010 Jun 23. Biochem Pharmacol. 2010. Retraction in: Biochem Pharmacol. 2016 Feb 15;102:142. doi: 10.1016/j.bcp.2015.11.007 PMID: 20599780 Free PMC article. Retracted.
658 results