Corradi V - Search Results

1

Identification of the first non-peptidic small molecule inhibitor of the c-Abl/14-3-3 protein-protein interactions able to drive sensitive and Imatinib-resistant leukemia cells to apoptosis.

Corradi V, Mancini M, Manetti F, Petta S, Santucci MA, Botta M. Corradi V, et al. Bioorg Med Chem Lett. 2010 Oct 15;20(20):6133-7. doi: 10.1016/j.bmcl.2010.08.019. Epub 2010 Aug 8. Bioorg Med Chem Lett. 2010. PMID: 20832303

2

Discovery and SAR of 1,3,4-thiadiazole derivatives as potent Abl tyrosine kinase inhibitors and cytodifferentiating agents.

Radi M, Crespan E, Botta G, Falchi F, Maga G, Manetti F, Corradi V, Mancini M, Santucci MA, Schenone S, Botta M. Radi M, et al. Among authors: corradi v. Bioorg Med Chem Lett. 2008 Feb 1;18(3):1207-11. doi: 10.1016/j.bmcl.2007.11.112. Epub 2007 Dec 4. Bioorg Med Chem Lett. 2008. PMID: 18078752

3

C6-unsubstituted pyrazolo[3,4-d]pyrimidines are dual Src/Abl inhibitors effective against imatinib mesylate resistant chronic myeloid leukemia cell lines.

Santucci MA, Corradi V, Mancini M, Manetti F, Radi M, Schenone S, Botta M. Santucci MA, et al. Among authors: corradi v. ChemMedChem. 2009 Jan;4(1):118-26. doi: 10.1002/cmdc.200800320. ChemMedChem. 2009. PMID: 19039816

4

mTOR inhibitor RAD001 (Everolimus) enhances the effects of imatinib in chronic myeloid leukemia by raising the nuclear expression of c-ABL protein.

Mancini M, Corradi V, Petta S, Martinelli G, Barbieri E, Santucci MA. Mancini M, et al. Among authors: corradi v. Leuk Res. 2010 May;34(5):641-8. doi: 10.1016/j.leukres.2009.07.012. Epub 2009 Jul 29. Leuk Res. 2010. PMID: 19643477

5

A new nonpeptidic inhibitor of 14-3-3 induces apoptotic cell death in chronic myeloid leukemia sensitive or resistant to imatinib.

Mancini M, Corradi V, Petta S, Barbieri E, Manetti F, Botta M, Santucci MA. Mancini M, et al. Among authors: corradi v. J Pharmacol Exp Ther. 2011 Mar;336(3):596-604. doi: 10.1124/jpet.110.172536. Epub 2010 Nov 1. J Pharmacol Exp Ther. 2011. PMID: 21041536

6

Computational techniques are valuable tools for the discovery of protein-protein interaction inhibitors: the 14-3-3σ case.

Corradi V, Mancini M, Santucci MA, Carlomagno T, Sanfelice D, Mori M, Vignaroli G, Falchi F, Manetti F, Radi M, Botta M. Corradi V, et al. Bioorg Med Chem Lett. 2011 Nov 15;21(22):6867-71. doi: 10.1016/j.bmcl.2011.09.011. Epub 2011 Sep 10. Bioorg Med Chem Lett. 2011. PMID: 21962576

7

Targets looking for drugs: a multistep computational protocol for the development of structure-based pharmacophores and their applications for hit discovery.

Tintori C, Corradi V, Magnani M, Manetti F, Botta M. Tintori C, et al. Among authors: corradi v. J Chem Inf Model. 2008 Nov;48(11):2166-79. doi: 10.1021/ci800105p. J Chem Inf Model. 2008. PMID: 18942779

8

14-3-3 ligand prevents nuclear import of c-ABL protein in chronic myeloid leukemia.

Mancini M, Veljkovic N, Corradi V, Zuffa E, Corrado P, Pagnotta E, Martinelli G, Barbieri E, Santucci MA. Mancini M, et al. Among authors: corradi v. Traffic. 2009 Jun;10(6):637-47. doi: 10.1111/j.1600-0854.2009.00897.x. Epub 2009 Feb 11. Traffic. 2009. PMID: 19220809 Free article.

9

New SRC/ABL inhibitors for chronic myeloid leukemia therapy show selectivity for T315I ABL mutant CD34(+) cells.

Santucci MA, Mancini M, Corradi V, Lacobucci I, Martinelli G, Botta M, Schenone S. Santucci MA, et al. Among authors: corradi v. Invest New Drugs. 2010 Dec;28(6):876-8. doi: 10.1007/s10637-009-9294-9. Epub 2009 Jul 24. Invest New Drugs. 2010. PMID: 19629392 No abstract available.

10

Small molecule inhibitors targeting HIV-1 reverse transcriptase dimerization.

Grohmann D, Corradi V, Elbasyouny M, Baude A, Horenkamp F, Laufer SD, Manetti F, Botta M, Restle T. Grohmann D, et al. Among authors: corradi v. Chembiochem. 2008 Apr 14;9(6):916-22. doi: 10.1002/cbic.200700669. Chembiochem. 2008. PMID: 18318036

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